OR21 HLA-C downregulation by HIV adapts to host HLA genotype
Apps R, Bachtel N, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete G, Chatterjee P, Lee G, Thomas R, Brockman M, Neil S, Carrington M, Bwana B, Bangsberg D, Martin J, Kallas E, Donini C, Cerqueira N, O’Doherty U, Hahn B, Jones B, Brumme Z, Nixon D. OR21 HLA-C downregulation by HIV adapts to host HLA genotype. Human Immunology 2018, 79: 28. DOI: 10.1016/j.humimm.2018.07.026.Peer-Reviewed Original ResearchDownregulation of HLAViral downregulationHLA genotypeChronic infectionPrimary HIV-1 virusesEffective anti-retroviral therapySpecific CTL responseAnti-retroviral therapyTreatment-naïve individualsViral immune evasionHLA-C allelesHIV-1 virusCTL responsesAcute infectionHIV infectionHLA moleculesViral protein VpuUntreated individualsImmune evasionHLAHIV virusViral modulationViral isolatesHIVInfection