OR21 HLA-C downregulation by HIV adapts to host HLA genotype
Apps R, Bachtel N, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete G, Chatterjee P, Lee G, Thomas R, Brockman M, Neil S, Carrington M, Bwana B, Bangsberg D, Martin J, Kallas E, Donini C, Cerqueira N, O’Doherty U, Hahn B, Jones B, Brumme Z, Nixon D. OR21 HLA-C downregulation by HIV adapts to host HLA genotype. Human Immunology 2018, 79: 28. DOI: 10.1016/j.humimm.2018.07.026.Peer-Reviewed Original ResearchDownregulation of HLAViral downregulationHLA genotypeChronic infectionPrimary HIV-1 virusesEffective anti-retroviral therapySpecific CTL responseAnti-retroviral therapyTreatment-naïve individualsViral immune evasionHLA-C allelesHIV-1 virusCTL responsesAcute infectionHIV infectionHLA moleculesViral protein VpuUntreated individualsImmune evasionHLAHIV virusViral modulationViral isolatesHIVInfectionHLA-C downregulation by HIV-1 adapts to host HLA genotype
Bachtel ND, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete GQ, Chatterjee P, Lee GQ, Thomas R, Brockman MA, Neil S, Carrington M, Bwana B, Bangsberg DR, Martin JN, Kallas EG, Donini C, Cerqueira NB, O’Doherty U, Hahn BH, Jones RB, Brumme ZL, Nixon DF, Apps R. HLA-C downregulation by HIV-1 adapts to host HLA genotype. PLOS Pathogens 2018, 14: e1007257. PMID: 30180214, PMCID: PMC6138419, DOI: 10.1371/journal.ppat.1007257.Peer-Reviewed Original ResearchConceptsViral downregulationHLA-C allelesHLA-C expressionChronic infectionHLA genotypeHIV-1Primary HIV-1 variantsPrimary HIV-1 virusesEffective anti-retroviral therapyAnti-retroviral therapyTreatment-naïve individualsDownregulation of HLAMonths of infectionHIV-1 variantsViral immune evasionHIV-1 virusSurface HLACTL responsesUntreated infectionViral protein VpuImmune evasionHLAInfectionInfected cellsDownregulationAllatostatin C modulates nociception and immunity in Drosophila
Bachtel ND, Hovsepian GA, Nixon DF, Eleftherianos I. Allatostatin C modulates nociception and immunity in Drosophila. Scientific Reports 2018, 8: 7501. PMID: 29760446, PMCID: PMC5951828, DOI: 10.1038/s41598-018-25855-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesBacterial InfectionsBlood ProteinsDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesHot TemperatureHyperalgesiaImmunityIon ChannelsMutationNeuropeptidesNociceptionPhotorhabdusReceptors, G-Protein-CoupledUp-RegulationConceptsReceptor 2Bacterial infectionsHost survivalAbsence of infectionLigand-gated ion channelsInflammatory painNociceptive neuronsChronic inflammationImmune infiltrationInflammatory responseAlters immunityImmunosuppressive substancesThermal nociceptionPathogenic bacterial infectionsNeuronal roleNociceptionRobust upregulationAllatostatin receptorImmune deficiency (IMD) pathwayBacterial challengeInfectionMicrobial stimulationImmune signalingHomeostatic conditionsDirect activation