OR21 HLA-C downregulation by HIV adapts to host HLA genotype
Apps R, Bachtel N, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete G, Chatterjee P, Lee G, Thomas R, Brockman M, Neil S, Carrington M, Bwana B, Bangsberg D, Martin J, Kallas E, Donini C, Cerqueira N, O’Doherty U, Hahn B, Jones B, Brumme Z, Nixon D. OR21 HLA-C downregulation by HIV adapts to host HLA genotype. Human Immunology 2018, 79: 28. DOI: 10.1016/j.humimm.2018.07.026.Peer-Reviewed Original ResearchDownregulation of HLAViral downregulationHLA genotypeChronic infectionPrimary HIV-1 virusesEffective anti-retroviral therapySpecific CTL responseAnti-retroviral therapyTreatment-naïve individualsViral immune evasionHLA-C allelesHIV-1 virusCTL responsesAcute infectionHIV infectionHLA moleculesViral protein VpuUntreated individualsImmune evasionHLAHIV virusViral modulationViral isolatesHIVInfectionP-A3 Limitations of CD32a expression as a marker of the HIV latent reservoir
Apps R, Bachtel N, Huang J, Ren Y, Tovanbutra S, Phanuphak N, Kroon E, Ananworanich J. P-A3 Limitations of CD32a expression as a marker of the HIV latent reservoir. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 77: 53. DOI: 10.1097/01.qai.0000532646.39289.6e.Peer-Reviewed Original ResearchReplication-competent HIVT cellsPeripheral bloodDirect markerHIV disease progressionT cell populationsCell-associated DNAHIV latent reservoirOriginal reportCD32a expressionLatent reservoirCD32 expressionDisease progressionHIV provirusCD4Flow cytometryLatent cellsCD32BloodInducible virusLack of correlationCell populationsExpression levelsHIVIgG binding