2018
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection
Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A. Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell 2018, 173: 443-455.e12. PMID: 29576450, PMCID: PMC5889333, DOI: 10.1016/j.cell.2018.02.047.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnemia, Hemolytic, CongenitalAnimalsBlack PeopleDehydrationDisease Models, AnimalErythrocytesGene DeletionGenotypeHumansHydrops FetalisIntermediate-Conductance Calcium-Activated Potassium ChannelsIon ChannelsMalariaMiceMice, Inbred C57BLMice, KnockoutPhenotypePlasmodium bergheiT-LymphocytesConceptsPlasmodium infectionRBC dehydrationRed blood cell dehydrationExperimental cerebral malariaRare genetic conditionHereditary xerocytosisCerebral malariaMouse modelMild hemolysisAfrican populationsInfectionMalaria resistanceGenetic conditionsFunction mutationsMalariaIon channelsRBCsPiezo1Most casesE756delAllelesCell dehydrationHigh frequencyPopulationXerocytosis
2016
Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic
Diehl WE, Lin AE, Grubaugh ND, Carvalho LM, Kim K, Kyawe PP, McCauley SM, Donnard E, Kucukural A, McDonel P, Schaffner SF, Garber M, Rambaut A, Andersen KG, Sabeti PC, Luban J. Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic. Cell 2016, 167: 1088-1098.e6. PMID: 27814506, PMCID: PMC5115602, DOI: 10.1016/j.cell.2016.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAfrica, WesternAmino Acid SubstitutionAnimalsCallithrixCarrier ProteinsCheirogaleidaeCytoplasmEbolavirusHemorrhagic Fever, EbolaHumansIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsNiemann-Pick C1 ProteinProtein Conformation, alpha-HelicalViral Envelope ProteinsVirionVirulenceConceptsHuman dendritic cellsIncreased infectivityEbola virus disease epidemicHuman hostEbola virus glycoproteinDendritic cellsHuman transmission eventsEVD epidemicEBOV-GPDisease severityViral mutationsViral infectivityPrimate cellsIntrinsic infectivityTransmission eventsInfectivityEpidemicVirus glycoproteinDisease epidemicsCellsNonsynonymous mutationsMutationsOutbreakHigh frequencyMortality