2024
Analysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development
Klontz E, Chowdhury N, Holbrook N, Solomon I, Telford S, Aliota M, Vogels C, Grubaugh N, Helgager J, Hughes H, Velez J, Piantadosi A, Chiu C, Lemieux J, Branda J. Analysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development. Viruses 2024, 16: 1653. DOI: 10.3390/v16111653.Peer-Reviewed Original ResearchGenome sequenceDiversity of genomic sequencesHuman infectionsPCR assay designVirus genome sequencesAssay designIn silico analysisBiology of infectionViral genomic dataGenetic diversityGenomic dataSensitivity of PCRGenomeCladePCR assayHuman diseasesVirulent strainsPCR designPowassan virusSequenceImmunocompromised patientsPCRTick-borne virusesAssay developmentClinical diagnostics
2023
Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics
Hollingsworth B, Grubaugh N, Lazzaro B, Murdock C. Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics. PLOS Pathogens 2023, 19: e1011588. PMID: 37651317, PMCID: PMC10470969, DOI: 10.1371/journal.ppat.1011588.Peer-Reviewed Original ResearchConceptsInsect-specific virusesPopulation structureMosquito viromeFine-scale genetic variationMosquito ecologyDiversity of virusesMosquito population structureMovement ratesMultiple spatial scalesViral ecologyGenetic variationHost genomeDisease ecologyCryptic aspectsVirome studiesEcologyViral discoveryViral phylogenyMosquito control programsViromeGenomeGenomic epidemiologySpatial scalesPhylogenyRelevant timescales
2021
Early Release - Tracing the Origin, Spread, and Molecular Evolution of Zika Virus in Puerto Rico, 2016–2017 - Volume 27, Number 11—November 2021 - Emerging Infectious Diseases journal - CDC
Santiago GA, Kalinich CC, Cruz-López F, González GL, Flores B, Hentoff A, Charriez KN, Fauver JR, Adams LE, Sharp TM, Black A, Bedford T, Ellis E, Ellis B, Waterman SH, Paz-Bailey G, Grubaugh ND, Muñoz-Jordán JL. Early Release - Tracing the Origin, Spread, and Molecular Evolution of Zika Virus in Puerto Rico, 2016–2017 - Volume 27, Number 11—November 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2971-2973. PMID: 34670646, PMCID: PMC8544999, DOI: 10.3201/eid2711.211575.Peer-Reviewed Original Research