Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.
Soong L, Chang CH, Sun J, Longley BJ, Ruddle NH, Flavell RA, McMahon-Pratt D. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. The Journal Of Immunology 1997, 158: 5374-83. PMID: 9164958, DOI: 10.4049/jimmunol.158.11.5374.Peer-Reviewed Original ResearchConceptsII-/- miceLeishmania amazonensis infectionRag2-/- miceT cellsAmazonensis infectionMHC classL. amazonensis-infected miceWild-type C57BL/6 miceLarge ulcerating lesionsMonocytes/granulocytesRole of CD4Course of infectionMonocytes/macrophagesStrains of miceMHC class IWild-type CD4T cell developmentUlcerating lesionFunctional CD4Lymphocyte subsetsC57BL/6 miceTh1 cellsInflammatory responseLesion pathologyImmune responseLYMPHOTOXIN-β AND TNF REGULATION IN T CELL SUBSETS: DIFFERENTIAL EFFECTS OF PGE2
Ferreri N, Millet I, Askari B, Magnani P, Ruddle N. LYMPHOTOXIN-β AND TNF REGULATION IN T CELL SUBSETS: DIFFERENTIAL EFFECTS OF PGE2. Cytokine 1997, 9: 157-165. PMID: 9126704, DOI: 10.1006/cyto.1996.0150.Peer-Reviewed Original ResearchConceptsT cell subsetsTumor necrosis factor alphaCell subsetsTNF mRNA accumulationProstaglandin E2Th2 cellsLT-betaCytokine productionTh1 cellsIL-3Effect of PGE2IL-4 mRNANecrosis factor alphaTh2 T cell clonesT cell clonesTh2 T cellsLT-beta mRNAOnly cytokineIL-4Factor alphaT cellsTNF regulationImmune responseInterleukin-4Lymphotoxin beta