2003
Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice
Oliver AR, Lyon GM, Ruddle NH. Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice. The Journal Of Immunology 2003, 171: 462-468. PMID: 12817031, DOI: 10.4049/jimmunol.171.1.462.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAutoantibodiesB-LymphocytesCell MovementDose-Response Relationship, ImmunologicEncephalomyelitis, Autoimmune, ExperimentalFemaleGlycoproteinsHumansImmunoglobulin GInjections, IntramuscularInterferon-gammaInterleukin-13MiceMice, Inbred C57BLMice, Mutant StrainsMolecular Sequence DataMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsRatsSpecies SpecificitySpinal CordConceptsExperimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinRat myelin oligodendrocyte glycoproteinHuman myelin oligodendrocyte glycoproteinMOG 35C57BL/6 miceMOG proteinAutoimmune encephalomyelitisOligodendrocyte glycoproteinB cellsCell responsesEncephalitogenic T cell responsesB cell-deficient miceB cell dependenceCell-deficient miceT cell responsesB cell responsesDifferent pathogenic mechanismsCNS infiltratesIL-13T cellsSpleen cellsIFN-gammaIgG subclassesAg presentation
1997
A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis
Suen W, Bergman C, Hjelmström P, Ruddle N. A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis. Journal Of Experimental Medicine 1997, 186: 1233-1240. PMID: 9334362, PMCID: PMC2199100, DOI: 10.1084/jem.186.8.1233.Peer-Reviewed Original ResearchConceptsExperimental allergic encephalomyelitisMaximum clinical scoreMyelin oligodendrocyte glycoproteinClinical scoresLT-alphaAllergic encephalomyelitisMultiple sclerosisCentral nervous system inflammationNervous system inflammationT cell productionDisease multiple sclerosisRat myelin oligodendrocyte glycoproteinAverage clinical scoreDisease indexWild-type littermatesWT T cellsNecrosis factor familyMOG 35CNS inflammationMOG antibodiesSystem inflammationWT miceC57BL/6 miceOligodendrocyte glycoproteinTNF-alpha