2024
The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro J, Narula S, Brenton J, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas J, de Seze J, Tenembaum S, Stone R, Casez O, Carra-Dallière C, Neuteboom R, Ahsan N, Arroyo H, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich D, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo C, Kantarci O, Shapiro E, Okuda D, Pelletier D. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. Journal Of Neurology 2024, 271: 4019-4027. PMID: 38564056, PMCID: PMC11323224, DOI: 10.1007/s00415-024-12289-1.Peer-Reviewed Original ResearchRadiologically isolated syndromeSpinal MRIDiagnostic workup of childrenMultiple sclerosisWorkup of childrenFisher's exact testMultivariate logistic regressionInternational longitudinal studyDiagnostic workupConsensus guidelinesExact testMS riskLogistic regressionConclusionsYoung childrenCSFBackgroundCerebrospinal fluidMRIPre-2017Longitudinal studySyndromeRadiologyChildrenAgeSexRisk
2016
International Pediatric MS Study Group Global Members Symposium report
Wassmer E, Chitnis T, Pohl D, Amato MP, Banwell B, Ghezzi A, Hintzen RQ, Krupp LB, Makhani N, Rostásy K, Tardieu M, Tenembaum S, Waldman A, Waubant E, Kornberg AJ. International Pediatric MS Study Group Global Members Symposium report. Neurology 2016, 87: s110-s116. PMID: 27572855, PMCID: PMC10688073, DOI: 10.1212/wnl.0000000000002880.Peer-Reviewed Original ResearchConceptsPediatric multiple sclerosisMultiple sclerosisInternational Pediatric Multiple Sclerosis Study GroupMultiple Sclerosis Study GroupOptimal vitamin D intakeEarly-onset multiple sclerosisNewer MS agentsAcute disseminated encephalomyelitisVitamin D intakeVitamin D deficiencyChildhood multiple sclerosisLong-term outcomesDrug treatment optionsDiverse patient samplesDifferentiation of MSEffective cognitive rehabilitationD intakeDisseminated encephalomyelitisD deficiencyNeuroinflammatory disordersNeuromyelitis opticaMS riskTreatment optionsMS outcomesClinical trials