2013
Functional Genomic Assessment of Phosgene-Induced Acute Lung Injury in Mice
Leikauf GD, Concel VJ, Bein K, Liu P, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA, Upadhyay S, Cario C, Di YP, Vuga LJ, Kostem E, Eskin E, You M, Kaminski N, Prows DR, Knoell DL, Fabisiak JP. Functional Genomic Assessment of Phosgene-Induced Acute Lung Injury in Mice. American Journal Of Respiratory Cell And Molecular Biology 2013, 49: 130522202035005. PMID: 23590305, PMCID: PMC3824050, DOI: 10.1165/rcmb.2012-0337oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAllelesAnimalsChemical Warfare AgentsChromosome MappingElectrophoretic Mobility Shift AssayFemaleGene ExpressionGene Expression ProfilingGenomeGenome-Wide Association StudyGenomicsGenotypeIntegrinsLungMiceMice, Inbred StrainsOligonucleotide Array Sequence AnalysisPhosgenePolymorphism, Single NucleotidePromoter Regions, GeneticReelin ProteinSodium-Potassium-Exchanging ATPaseConceptsSignificant SNP associationsSNP associationsTranscriptomic analysisCompetitive electrophoretic mobility shift analysisGenome-wide association mappingFunctional genomic assessmentPutative transcription factorElectrophoretic mobility shift analysisMobility shift analysisAssociation mappingGenetic resolutionTranscription factorsCandidate genesFunctional domainsNonsynonymous SNPsGenomic assessmentPhenotypic differencesPhenotypic extremesDiverse panelGenesGenetic determinantsShift analysisPTPRTAllelesITGA9
2009
FACS-Assisted Microarray Profiling Implicates Novel Genes and Pathways in Zebrafish Gastrointestinal Tract Development
Stuckenholz C, Lu L, Thakur P, Kaminski N, Bahary N. FACS-Assisted Microarray Profiling Implicates Novel Genes and Pathways in Zebrafish Gastrointestinal Tract Development. Gastroenterology 2009, 137: 1321-1332. PMID: 19563808, PMCID: PMC2785077, DOI: 10.1053/j.gastro.2009.06.050.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell SeparationChromosomes, Human, Pair 8Digestive System NeoplasmsFlow CytometryGastrointestinal TractGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Expression Regulation, NeoplasticGene Regulatory NetworksGreen Fluorescent ProteinsHumansIn Situ HybridizationLarvaMicroRNAsOligonucleotide Array Sequence AnalysisOrganogenesisReproducibility of ResultsTime FactorsZebrafishZebrafish ProteinsConceptsFluorescence-activated cell sortingNovel genesGreen fluorescent proteinGene networksPutative transcription factorTransgenic zebrafish lineZebrafish Danio rerioPhosphatidylinositol-3-kinase (PI3K) pathwayExcellent model systemDevelopmental time pointsChromosome arm 8qGastrointestinal developmentZebrafish lineHuman orthologDanio rerioTranscription factorsKinase pathwayMicroarray profilingFluorescent proteinGFP expressionGenesNovel pathwayGFP cellsCell sortingOrganogenesis