2024
Chest computed tomography provides more information than chest X-ray alone in determining extent of physiologic impairment in pulmonary sarcoidosis
Benn B, Lippitt W, Cortopassi I, Balasubramani G, Mortani Barbosa E, Drake W, Herzog E, Gibson K, Chen E, Koth L, Fuhrman C, Lynch D, Kaminski N, Wisniewski S, Carlson N, Maier L. Chest computed tomography provides more information than chest X-ray alone in determining extent of physiologic impairment in pulmonary sarcoidosis. CHEST Journal 2024 PMID: 38830401, DOI: 10.1016/j.chest.2024.04.031.Peer-Reviewed Original ResearchScadding stageCT featuresLung functionChest radiologistsCT scanAlpha-1 anti-trypsin deficiencyChest computed tomographyChest CT scanChest X-rayIncreasing clinical useCompare demographic featuresAssociated with FEV1Visual scoring systemSarcoidosis stagePulmonary sarcoidosisChest CTCT findingsAssociated with lung functionCT assessmentComputed tomographySarcoidosisClinical useRadiological measurementsCT measurementsScoring systemCXCL10+ Monocyte-derived Macrophages Are Potential Drivers of TH17.1 Inflammation in Pulmonary Sarcoidosis
Ruwisch J, Schupp J, Bartkute B, Artysh N, Kaminski N, Prasse A. CXCL10+ Monocyte-derived Macrophages Are Potential Drivers of TH17.1 Inflammation in Pulmonary Sarcoidosis. 2024, a2510-a2510. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2510.Peer-Reviewed Original ResearchMonocyte-derived macrophagesPulmonary sarcoidosis
2017
Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis
Hawkins C, Shaginurova G, Shelton DA, Herazo-Maya JD, Oswald-Richter KA, Rotsinger JE, Young A, Celada LJ, Kaminski N, Sevin C, Drake WP. Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. Journal Of Immunology Research 2017, 2017: 3642832. PMID: 29234685, PMCID: PMC5695030, DOI: 10.1155/2017/3642832.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedApoptosisCD4-Positive T-LymphocytesCell ProliferationCells, CulturedClonal AnergyCytokinesDisease ProgressionFemaleGene Expression RegulationHumansLymphocyte ActivationMaleMiddle AgedProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell, alpha-betaSarcoidosis, PulmonaryTh1 CellsYoung AdultConceptsT cell exhaustionTh1 cytokine expressionPD-1 expressionCell exhaustionCytokine expressionT cellsHealthy controlsInhibitory cell surface receptorsT cell immune functionTh1 immune responseChronic antigenic stimulationCell immune functionProliferative capacityT cell functionSarcoidosis subjectsSystemic CD4Pulmonary sarcoidosisDisease resolutionProgressive diseaseClinical resolutionCytokine productionAntigenic stimulationDisease progressionImmune responseCD4