2020
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6: eaba1983. PMID: 32832599, PMCID: PMC7439502, DOI: 10.1126/sciadv.aba1983.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisVascular endothelial cellsIPF lungsPulmonary fibrosisChronic obstructive pulmonary disease (COPD) lungsFatal interstitial lung diseaseEndothelial cellsInterstitial lung diseaseCell populationsIPF myofibroblastsMyofibroblast fociNonsmoker controlsLung diseaseCOPD lungsBasaloid cellsSingle-cell atlasInvasive fibroblastsMacrophage populationsLungStromal cellsEpithelial cellsFibrosisCellular populationsDevelopmental markersSingle-cell RNA-seq
2013
Micromanaging microRNAs: using murine models to study microRNAs in lung fibrosis
Cardenas C, Kaminski N, Kass DJ. Micromanaging microRNAs: using murine models to study microRNAs in lung fibrosis. Drug Discovery Today Disease Models 2013, 10: e145-e151. PMID: 25328532, PMCID: PMC4201640, DOI: 10.1016/j.ddmod.2012.11.003.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisLung fibrosisAlveolar cell hyperplasiaInterstitial lung diseaseExtensive phenotypic changesRole of microRNAsMyofibroblast fociPulmonary fibrosisCell hyperplasiaLung diseaseLung healthUnknown etiologyMurine modelTranscriptional programmingAnimal modelsFibrosisPhenotypic changesPathological processesDiseaseExtracellular matrixMicroRNAsLatest insightsSpecific patternsHyperplasiaLung