2023
PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection
Asashima H, Mohanty S, Comi M, Ruff W, Hoehn K, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein S, Montgomery R, Iwasaki A, Dela Cruz C, Kaminski N, Shaw A, Hafler D, Sumida T. PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection. Cell Reports 2023, 42: 111895. PMID: 36596303, PMCID: PMC9806868, DOI: 10.1016/j.celrep.2022.111895.Peer-Reviewed Original ResearchConceptsAcute viral infectionTph cellsViral infectionCXCR3 expressionClinical outcomesHelper TSevere viral infectionsB cell helpBetter clinical outcomesProtective humoral immunityT cell-B cell interactionsKey immune responsesPlasmablast expansionB cell differentiationCell subsetsHumoral immunityCell helpImmune responseInterferon γPlasmablast differentiationB cellsPlasmablastsCell responsesInfectionCD4
2020
Assessment of viral RNA in idiopathic pulmonary fibrosis using RNA-seq
Yin Q, Strong MJ, Zhuang Y, Flemington EK, Kaminski N, de Andrade JA, Lasky JA. Assessment of viral RNA in idiopathic pulmonary fibrosis using RNA-seq. BMC Pulmonary Medicine 2020, 20: 81. PMID: 32245461, PMCID: PMC7119082, DOI: 10.1186/s12890-020-1114-1.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisViral RNA expressionViral infectionPulmonary fibrosisPathogenesis of IPFLung biopsy samplesRNA expressionHerpes virus infectionLow-level evidenceReal-time RT-PCRAcute exacerbationControl lungsLung tissueVirus infectionBiopsy samplesSelect virusesPossible associationInfectionRT-PCRStatistical differenceNext-generation sequencingViral RNAFibrosisVirusRNA-seq results
2017
Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice
Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR. Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. The Journal Of Immunology 2017, 199: 1060-1068. PMID: 28646038, PMCID: PMC5557035, DOI: 10.4049/jimmunol.1700397.Peer-Reviewed Original ResearchConceptsAlveolar macrophage phagocytosisInfluenza infectionAlveolar macrophagesLung damageMacrophage phagocytosisOlder peopleInfluenza-induced mortalityInfluenza viral infectionRetention of neutrophilsRespiratory virusesLung homeostasisLung infectionCell cycling pathwaysMurine modelViral infectionImpact immunityDefective phagocytosisApoptotic neutrophilsInfectionMacrophagesMortalityPhagocytosisNeutrophilsTranscriptional profilesCD204
2007
Acute Exacerbations of Idiopathic Pulmonary Fibrosis
Collard HR, Moore BB, Flaherty KR, Brown KK, Kaner RJ, King TE, Lasky JA, Loyd JE, Noth I, Olman MA, Raghu G, Roman J, Ryu JH, Zisman DA, Hunninghake GW, Colby TV, Egan JJ, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kondoh Y, Lynch DA, Müller-Quernheim J, Myers JL, Nicholson AG, Selman M, Toews GB, Wells AU, Martinez FJ, Investigators T. Acute Exacerbations of Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2007, 176: 636-643. PMID: 17585107, PMCID: PMC2094133, DOI: 10.1164/rccm.200703-463pp.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAcute exacerbationAcute deteriorationPulmonary fibrosisBilateral radiographic opacitiesAbsence of infectionPrecipitous courseIdentifiable etiologyLung functionRespiratory statusUnknown etiologyUnidentifiable causeDiagnostic criteriaPathobiological roleExacerbationRadiographic opacitiesNatural historyRecent evidencePatientsFibrosisEtiologyInfectionPredictable declineSignificant deteriorationDeterioration