From signatures to models: understanding cancer using microarrays
Segal E, Friedman N, Kaminski N, Regev A, Koller D. From signatures to models: understanding cancer using microarrays. Nature Genetics 2005, 37: s38-s45. PMID: 15920529, DOI: 10.1038/ng1561.Peer-Reviewed Original ResearchConceptsTranscriptional networksModel organismsRegulatory mechanismsBiological processesMolecular underpinningsMechanistic understandingModular organizationDisease mechanismsComputational analysisComprehensive viewGenomicsRobust signatureOrganismsMicroarrayComparative analysisMechanismSignaturesCellsCancerManagement of cancer