2016
Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood
Alteba S, Korem N, Akirav I. Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood. Learning & Memory 2016, 23: 349-358. PMID: 27317195, PMCID: PMC4918780, DOI: 10.1101/lm.041608.116.Peer-Reviewed Original ResearchConceptsEarly life stressLate adolescenceRecognition taskLife stressCannabinoid CB1/2 receptor agonistNovel object recognition taskEffects of ELSSocial recognition taskShort-term memoryCB1/2 receptor agonistObject recognition taskAnxiety-related disordersStress-induced impairmentRecognition memoryFear circuitImpaired performanceNeurocognitive performanceTreatment of stressCognitive deficitsNeurocognitive functionAnxiety levelsCB1 receptorsEarly stressPFC GRSpatial location
2015
Targeting the endocannabinoid system to treat anxiety-related disorders
Korem N, Zer-Aviv T, Ganon-Elazar E, Abush H, Akirav I. Targeting the endocannabinoid system to treat anxiety-related disorders. Journal Of Basic And Clinical Physiology And Pharmacology 2015, 27: 193-202. PMID: 26426887, DOI: 10.1515/jbcpp-2015-0058.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-traumatic stress disorderEndocannabinoid systemAnxiety-related disordersCommon self-reported reasonsAdministration of cannabinoidsEncouraging preclinical dataEffects of cannabinoidsAnxiety-like behaviorExogenous cannabinoidsPreclinical dataSelf-reported reasonsChronic usageUntoward effectsAnxiogenic effectsMouse modelPsychiatric disordersAnimal modelsPTSD patientsClinical settingPreclinical researchStress disorderAnxiety disordersCannabinoidsDisordersControl of emotions
2014
Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
Korem N, Akirav I. Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing. Neuropsychopharmacology 2014, 39: 2709-2722. PMID: 24897957, PMCID: PMC4200492, DOI: 10.1038/npp.2014.132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoxazinesBrainCannabinoid Receptor AgonistsCannabinoidsCuesDisease Models, AnimalElectroshockEmotionsExtinction, PsychologicalLong-Term PotentiationMaleMorpholinesNaphthalenesNeuronal PlasticityRats, Sprague-DawleyReceptors, CannabinoidReceptors, GlucocorticoidReflex, StartleSpace PerceptionStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderSituational remindersEmotional processingPrefrontal cortexTrauma exposureTraumatic eventsBasolateral amygdalaPTSD-like symptomsTrajectory of PTSDCB1/2 receptor agonistCB1 receptorsGlucocorticoid receptorImpaired extinctionSingle footshockStress disorderBrain areasFootshockCB1R expressionImpaired plasticityReceptor agonistDay 1Day 3ProcessingCA1Altered expression