2019
Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci
Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB, Program D, Program M. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biological Psychiatry 2019, 86: 365-376. PMID: 31151762, PMCID: PMC6919570, DOI: 10.1016/j.biopsych.2019.03.984.Peer-Reviewed Original ResearchConceptsAdditional genome-wide significant lociRisk lociWide association study (GWAS) analysisAssociation studiesGenome-wide significant lociGenome-wide association studiesGenetic correlationsWide association studyNovel risk lociAlcohol-related traitsStrong statistical supportSmoking-related traitsAdditional genomesSignificant lociPancreatic delta cellsChromosome 4Chromosome 11Protein productsChromosome 8Quantitative phenotypesMillion Veteran ProgramVeterans Affairs Million Veteran ProgramLociCell typesChromosome 17
2010
Testing Predictions From Personality Neuroscience
DeYoung CG, Hirsh JB, Shane MS, Papademetris X, Rajeevan N, Gray JR. Testing Predictions From Personality Neuroscience. Psychological Science 2010, 21: 820-828. PMID: 20435951, PMCID: PMC3049165, DOI: 10.1177/0956797610370159.Peer-Reviewed Original ResearchConceptsPersonality neuroscienceBrain regionsLateral prefrontal cortexMedial orbitofrontal cortexBig Five personalityStructural magnetic resonance imagingNegative affectReward informationMental statesOrbitofrontal cortexPrefrontal cortexBig FiveDifferent brain regionsVoluntary controlExplanatory modelsWhole brain volumeConscientiousnessNeuroscienceExtraversionAgreeablenessNeuroticismHealthy adultsBiological basisCortexMagnetic resonance imaging
2009
Variation in orbitofrontal cortex volume: relation to sex, emotion regulation and affect
Welborn BL, Papademetris X, Reis DL, Rajeevan N, Bloise SM, Gray JR. Variation in orbitofrontal cortex volume: relation to sex, emotion regulation and affect. Social Cognitive And Affective Neuroscience 2009, 4: 328-339. PMID: 20019072, PMCID: PMC2799952, DOI: 10.1093/scan/nsp028.Peer-Reviewed Original ResearchConceptsAffective individual differencesEmotion regulationIndividual differencesSelf-reported emotion regulation strategiesVmPFC volumeSex differencesEmotion regulation strategiesOrbitofrontal Cortex SubregionsHealthy right-handed adultsVentromedial prefrontal cortexBrain structuresRight-handed adultsEmotion suppressionPositive emotionsBrain volumeRegulation strategiesSomatic anxietyEmotional impulsesOrbitofrontal cortex structurePrefrontal cortexPlanum temporaleLateral orbitofrontalRight lateral orbitofrontalCortex volumeCortex structureFunctional connectivity and alterations in baseline brain state in humans
Martuzzi R, Ramani R, Qiu M, Rajeevan N, Constable RT. Functional connectivity and alterations in baseline brain state in humans. NeuroImage 2009, 49: 823-834. PMID: 19631277, PMCID: PMC2764802, DOI: 10.1016/j.neuroimage.2009.07.028.Peer-Reviewed Original ResearchConceptsDefault mode networkMAC sevoflurane anesthesiaBaseline brain activityFunctional connectivity fMRISevoflurane anesthesiaHigher-order brain regionsAnesthetized conditionSensory cortexDifferent brain networksBaseline activityBrain regionsHuman volunteersSensory areasFunctional connectivityAnesthesiaMode networkLow-level sensory areasBrain networksBrain activityCognitive regionsBrain propertiesBrain statesFurther evidencePainThalamus
2008
Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects
Qiu M, Ramani R, Swetye M, Rajeevan N, Constable RT. Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects. Magnetic Resonance In Medicine 2008, 60: 987-996. PMID: 18816821, PMCID: PMC2716171, DOI: 10.1002/mrm.21759.Peer-Reviewed Original ResearchConceptsCerebral blood flowLow-dose sevofluraneRegional cerebral blood flowTask-induced changesBaseline cerebral blood flowBlood oxygen level-dependent (BOLD) signalAbsence of anesthesiaHealthy human subjectsHuman subjectsNormal human subjectsLevel-dependent signalFunctional MR imagingVascular measuresAnesthetic agentsBlood flowAnesthetic effectSevofluraneFunctional MRI dataAnesthesia conditionsAnesthesiaMR imagingAuditory regionsOxidative metabolismAuditory stimuliFMRI study