1999
Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRS
Verhoeff N, Petroff O, Hyder F, Zoghbi S, Fujita M, Rajeevan N, Rothman D, Seibyl J, Mattson R, Innis R. Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRS. Epilepsia 1999, 40: 1433-1438. PMID: 10528940, DOI: 10.1111/j.1528-1157.1999.tb02016.x.Peer-Reviewed Original ResearchConceptsEffects of vigabatrinGABA levelsTissue GABA levelsMR imagingCentral gamma-aminobutyric acidGABA magnetic resonance spectroscopyDistribution volumeHealthy age-matched controlsOccipital GABA levelsAge-matched controlsGamma-aminobutyric acidVolume of interestSingle photon emissionMagnetic resonance spectroscopyTotal plasma activityT1-weighted MR imagingPartial seizuresGABAergic systemOccipital cortexConstant infusion methodPlasma activityVigabatrinOccipital activityEffective doseWilcoxon test
1998
Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil
Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsBenzodiazepine receptorsComparison subjectsAlcoholic subjectsDistribution volumeAlcoholic patientsAnterior cingulateBenzodiazepine receptor densityRight middle frontal gyrusLeft occipital cortexType II alcoholismSingle photon emissionMiddle frontal gyrusStatistical parametric mappingContinuous infusionReceptor radiotracerReceptor densityOccipital cortexCerebellar cortexCortical regionsPatientsFrontal gyrusInterest analysisVivo studiesParametric mapping