2008
Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects
Qiu M, Ramani R, Swetye M, Rajeevan N, Constable RT. Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects. Magnetic Resonance In Medicine 2008, 60: 987-996. PMID: 18816821, PMCID: PMC2716171, DOI: 10.1002/mrm.21759.Peer-Reviewed Original ResearchConceptsCerebral blood flowLow-dose sevofluraneRegional cerebral blood flowTask-induced changesBaseline cerebral blood flowBlood oxygen level-dependent (BOLD) signalAbsence of anesthesiaHealthy human subjectsHuman subjectsNormal human subjectsLevel-dependent signalFunctional MR imagingVascular measuresAnesthetic agentsBlood flowAnesthetic effectSevofluraneFunctional MRI dataAnesthesia conditionsAnesthesiaMR imagingAuditory regionsOxidative metabolismAuditory stimuliFMRI study
1999
Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRS
Verhoeff N, Petroff O, Hyder F, Zoghbi S, Fujita M, Rajeevan N, Rothman D, Seibyl J, Mattson R, Innis R. Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRS. Epilepsia 1999, 40: 1433-1438. PMID: 10528940, DOI: 10.1111/j.1528-1157.1999.tb02016.x.Peer-Reviewed Original ResearchConceptsEffects of vigabatrinGABA levelsTissue GABA levelsMR imagingCentral gamma-aminobutyric acidGABA magnetic resonance spectroscopyDistribution volumeHealthy age-matched controlsOccipital GABA levelsAge-matched controlsGamma-aminobutyric acidVolume of interestSingle photon emissionMagnetic resonance spectroscopyTotal plasma activityT1-weighted MR imagingPartial seizuresGABAergic systemOccipital cortexConstant infusion methodPlasma activityVigabatrinOccipital activityEffective doseWilcoxon test