2017
Effect of simvastatin on baboon endometriosis†
Taylor HS, Alderman M, D'Hooghe TM, Fazleabas AT, Duleba AJ. Effect of simvastatin on baboon endometriosis†. Biology Of Reproduction 2017, 97: 32-38. PMID: 28637327, PMCID: PMC6248548, DOI: 10.1093/biolre/iox058.Peer-Reviewed Original ResearchConceptsEffect of simvastatinEndometriotic lesionsRed lesionsMarkers of inflammationEndometrial stromal cellsDevelopment of endometriosisEstrogen receptor betaImmune system activationEstrogen receptor alphaMarkers of proliferationSteroid hormone responsesCell nuclear antigenEndometrial lesionsEndometrial tissueEutopic endometriumReproductive agePrimate modelWhite lesionsCommon disorderEstrogen receptorBaboon modelMurine modelTreatment groupsSystem activationReceptor alphaThe Systemic Effects of Endometriosis
Alderman MH, Yoder N, Taylor HS. The Systemic Effects of Endometriosis. Seminars In Reproductive Medicine 2017, 35: 263-270. PMID: 28658710, DOI: 10.1055/s-0037-1603582.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic effectsTreatment of patientsMultiple organ systemsMore effective treatmentsPelvic painEndometrial glandsAutoimmune diseasesBroader systemic effectsCardiovascular diseaseEffective treatmentEndometriosisBody weightPsychiatric conditionsOrgan systemsEctopic locationsStem cell migrationDiseaseComorbiditiesCell migrationTreatmentHypothesized mechanismsDysmenorrheaPainPatientsPathophysiology
2016
Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen EM, Alderman MH, Taylor HS. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure. The FASEB Journal 2016, 30: 3194-3201. PMID: 27312807, PMCID: PMC5001514, DOI: 10.1096/fj.201500089r.Peer-Reviewed Original ResearchConceptsEstrogen responseSubsequent gene expressionGene expressionXenoestrogen exposureBPA exposureEpigenetic programmingUtero BPA exposurePrenatal BPA exposureRisk of estrogenMajority of genesNormal developmental programmingFemale reproductive disordersCpG methylation patternsCpG methylation profilesEstrogen-responsive gene expressionUterine DNAEstrogen-responsive genesEndometrial hyperplasiaUtero exposurePregnant miceEtiological factorsBreast cancerEstrogen receptorMethylation patternsRelevant dose