2022
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2016
Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen EM, Alderman MH, Taylor HS. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure. The FASEB Journal 2016, 30: 3194-3201. PMID: 27312807, PMCID: PMC5001514, DOI: 10.1096/fj.201500089r.Peer-Reviewed Original ResearchConceptsEstrogen responseSubsequent gene expressionGene expressionXenoestrogen exposureBPA exposureEpigenetic programmingUtero BPA exposurePrenatal BPA exposureRisk of estrogenMajority of genesNormal developmental programmingFemale reproductive disordersCpG methylation patternsCpG methylation profilesEstrogen-responsive gene expressionUterine DNAEstrogen-responsive genesEndometrial hyperplasiaUtero exposurePregnant miceEtiological factorsBreast cancerEstrogen receptorMethylation patternsRelevant dose