2014
FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-Like Receptor Signaling
Bhattacharyya S, Tamaki Z, Wang W, Hinchcliff M, Hoover P, Getsios S, White ES, Varga J. FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-Like Receptor Signaling. Science Translational Medicine 2014, 6: 232ra50. PMID: 24739758, PMCID: PMC4414050, DOI: 10.1126/scitranslmed.3008264.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Endogenous TLR4 ligandsCutaneous fibrosisTLR4 ligandToll-like receptor signalingProgressive autoimmune diseaseLesional skin biopsiesFibronectin extra domain ATreatment of fibrosisTissue repair responseHallmark of sclerodermaPersistent fibroblast activationExtra domain ATLR4 blockadeAutoimmune diseasesChronic conditionsChronic fibrosisReceptor 4Skin biopsiesFibrotic responseOrganotypic skin equivalentsMultiple organsPotent stimulusSclerodermaFibroblast activation
2011
Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps
Tan BK, Li QZ, Suh L, Kato A, Conley DB, Chandra RK, Zhou J, Norton J, Carter R, Hinchcliff M, Harris K, Peters A, Grammer LC, Kern RC, Mohan C, Schleimer RP. Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps. Journal Of Allergy And Clinical Immunology 2011, 128: 1198-1206.e1. PMID: 21996343, PMCID: PMC3384688, DOI: 10.1016/j.jaci.2011.08.037.Peer-Reviewed Original ResearchConceptsPresence of autoantibodiesChronic rhinosinusitisNasal polypsNasal tissueAnti-dsDNA antibody levelsSelf-reactive B cell clonesIgA-secreting plasma cellsB-cell activating factorControl nasal tissueEvidence of autoimmunityAnti-dsDNA IgGB cell clonesPotential of antibodiesAutoantibody microarrayAutoantibody levelsIgA antibodiesSpecific autoantibodiesAntibody levelsSubepithelial depositionAutoimmune diseasesSinonasal tissueControl subjectsInflammatory conditionsRevision surgeryImmunoglobulin production