2018
Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry
Carlson DA, Kou W, Lin Z, Hinchcliff M, Thakrar A, Falmagne S, Prescott J, Dorian E, Kahrilas PJ, Pandolfino JE. Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry. Clinical Gastroenterology And Hepatology 2018, 17: 674-681.e1. PMID: 30081222, PMCID: PMC6360138, DOI: 10.1016/j.cgh.2018.07.042.Peer-Reviewed Original ResearchConceptsRepetitive antegrade contractionsEGJ-DIFLIP panometryDistensibility plateauAntegrade contractionsEsophageal contractilityEsophagogastric junctionEsophageal distensibilityAsymptomatic volunteersClinical practiceFunctional luminal imaging probe (FLIP) panometryEGJ-distensibility indexSedated upper endoscopyTime of endoscopyProximal esophageal bodyRAC patternUpper endoscopyDistal esophagusEosinophilic esophagitisEsophageal bodyNormal findingsProspective studyEsophageal diseaseDistal bodyHealthy individuals
2017
A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis
Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML. A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis. Genome Medicine 2017, 9: 27. PMID: 28330499, PMCID: PMC5363043, DOI: 10.1186/s13073-017-0417-1.Peer-Reviewed Original ResearchConceptsDisease-associated signaturesFunctional genomic networksGene expression signaturesPulmonary fibrosisAutoimmune diseasesDisease processMulti-organ autoimmune diseaseDistinct underlying pathologyPro-fibrotic macrophagesInternal organ involvementPulmonary arterial hypertensionExpression signaturesSkin of patientsInnate immune systemWilcoxon rank sum testGenomic networksRank sum testBackgroundSystemic sclerosisArterial hypertensionOrgan involvementSystemic sclerosisUnderlying pathologyLung microenvironmentSkin fibrosisFibrotic genes
2016
Loss of Peristaltic Reserve, Determined by Multiple Rapid Swallows, Is the Most Frequent Esophageal Motility Abnormality in Patients With Systemic Sclerosis
Carlson DA, Crowell MD, Kimmel JN, Patel A, Gyawali CP, Hinchcliff M, Griffing WL, Pandolfino JE, Vela MF. Loss of Peristaltic Reserve, Determined by Multiple Rapid Swallows, Is the Most Frequent Esophageal Motility Abnormality in Patients With Systemic Sclerosis. Clinical Gastroenterology And Hepatology 2016, 14: 1502-1506. PMID: 27062902, PMCID: PMC5028229, DOI: 10.1016/j.cgh.2016.03.039.Peer-Reviewed Original ResearchConceptsMultiple rapid swallowsHigh-resolution manometrySystemic sclerosisDistal contractile integralPeristaltic reserveEsophageal motility diagnosisRapid swallowsMotility diagnosisContractile integralEsophageal motility findingsEsophageal high-resolution manometryTertiary referral centerIneffective esophageal motilityMedian distal contractile integralEsophageal motility abnormalitiesEsophageal motility disordersAbsent contractilityHRM findingsMotility findingsReferral centerEsophageal motilityMotility abnormalitiesMotility disordersRetrospective analysisSupine swallowsThe association between systemic sclerosis disease manifestations and esophageal high‐resolution manometry parameters
Kimmel JN, Carlson DA, Hinchcliff M, Carns MA, Aren KA, Lee J, Pandolfino JE. The association between systemic sclerosis disease manifestations and esophageal high‐resolution manometry parameters. Neurogastroenterology & Motility 2016, 28: 1157-1165. PMID: 26921101, PMCID: PMC4956560, DOI: 10.1111/nmo.12813.Peer-Reviewed Original ResearchConceptsHigh-resolution manometrySSc disease durationClinical characteristicsMotility diagnosisNormal motilityHigh-resolution manometry parametersSevere esophageal dysfunctionWorse lung functionIneffective esophageal motilityPulmonary function testsRetrospective chart reviewRodnan skin scoreSkin disease severitySymptoms of dysphagiaAbsent contractilityEsophageal dysfunctionChart reviewSkin involvementSSc patientsLung functionSkin scoreSystemic manifestationsSystemic sclerosisEsophageal contractilityEsophageal motilityEsophageal dilatation and interstitial lung disease in systemic sclerosis: A cross-sectional study
Richardson C, Agrawal R, Lee J, Almagor O, Nelson R, Varga J, Cuttica MJ, Dematte J, Chang RW, Hinchcliff ME. Esophageal dilatation and interstitial lung disease in systemic sclerosis: A cross-sectional study. Seminars In Arthritis And Rheumatism 2016, 46: 109-114. PMID: 27033049, PMCID: PMC5500283, DOI: 10.1016/j.semarthrit.2016.02.004.Peer-Reviewed Original ResearchConceptsRadiographic interstitial lung diseaseSSc interstitial lung diseaseInterstitial lung diseaseSystemic sclerosisCross-sectional studyEsophageal diameterEsophageal dilatationLung diseaseProgression of ILDSSc disease subtypesPulmonary function testsRodnan skin scoreErythrocyte sedimentation rateSecondary outcome variablesBody mass indexGround-glass opacitiesProton pump inhibitorsLow lung volumesSemi-quantitative scoreRegistry patientsDisease durationLow DLCOSkin scoreMedication useSerum autoantibodies
2015
Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures
Taroni JN, Martyanov V, Huang CC, Mahoney JM, Hirano I, Shetuni B, Yang GY, Brenner D, Jung B, Wood TA, Bhattacharyya S, Almagor O, Lee J, Sirajuddin A, Varga J, Chang RW, Whitfield ML, Hinchcliff M. Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures. Arthritis Research & Therapy 2015, 17: 194. PMID: 26220546, PMCID: PMC4518531, DOI: 10.1186/s13075-015-0695-1.Peer-Reviewed Original ResearchConceptsSystemic sclerosisEsophageal biopsiesInflammatory signatureLarge inflammatory infiltratesConsecutive SSc patientsSmooth muscle atrophyAbsence of fibrosisSmooth muscle functionProliferative gene expression signatureGene expression subsetsSmooth muscle cellsEsophageal dilatationGene expression signaturesSSc patientsEsophageal fibrosisSerum autoantibodiesInflammatory infiltrateEsophageal pathologyImmune activationAutopsy studySSc pathogenesisSSc casesMolecular subsetsGene expressionMuscle atrophy