2020
Gastroesophageal Reflux
Masoud A, Hinchcliff M. Gastroesophageal Reflux. In Clinical Practice 2020, 179-191. DOI: 10.1007/978-3-030-53736-4_16.Peer-Reviewed Original ResearchGastroesophageal refluxSystemic sclerosisGastric antral vascular ectasia (GAVE) syndromePatient-reported health-related qualityRheumatism 2013 classification criteriaRheumatology/European LeagueSmall bowel bacterial overgrowthMajor underlying pathologyHealth-related qualitySmooth muscle atrophyControl of refluxBowel bacterial overgrowthLower esophageal sphincterOptimal patient carePharyngeal symptomsAspiration pneumonitisFecal incontinencePeptic strictureAggressive preventionBacterial overgrowthGastric emptyingEsophageal sphincterUnderlying pathologyBarrett's esophagusEsophageal adenocarcinoma
2015
Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures
Taroni JN, Martyanov V, Huang CC, Mahoney JM, Hirano I, Shetuni B, Yang GY, Brenner D, Jung B, Wood TA, Bhattacharyya S, Almagor O, Lee J, Sirajuddin A, Varga J, Chang RW, Whitfield ML, Hinchcliff M. Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures. Arthritis Research & Therapy 2015, 17: 194. PMID: 26220546, PMCID: PMC4518531, DOI: 10.1186/s13075-015-0695-1.Peer-Reviewed Original ResearchConceptsSystemic sclerosisEsophageal biopsiesInflammatory signatureLarge inflammatory infiltratesConsecutive SSc patientsSmooth muscle atrophyAbsence of fibrosisSmooth muscle functionProliferative gene expression signatureGene expression subsetsSmooth muscle cellsEsophageal dilatationGene expression signaturesSSc patientsEsophageal fibrosisSerum autoantibodiesInflammatory infiltrateEsophageal pathologyImmune activationAutopsy studySSc pathogenesisSSc casesMolecular subsetsGene expressionMuscle atrophy