Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis
Valenzuela A, Baron M, Rodriguez-Reyna TS, Proudman S, Khanna D, Young A, Hinchcliff M, Steen V, Gordon J, Hsu V, Castelino FV, Schoenfeld S, Li S, Wu JY, Fiorentino D, Chung L. Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis. Seminars In Arthritis And Rheumatism 2020, 50: 891-896. PMID: 32898758, PMCID: PMC8205269, DOI: 10.1016/j.semarthrit.2020.06.007.Peer-Reviewed Original ResearchConceptsSSc patientsSystemic sclerosisDigital ischemiaHealth Assessment Questionnaire Disability IndexCochin Hand Functional ScaleACR/EULAR criteriaSubcutaneous calcium depositionConsecutive SSc patientsSubset of patientsMedian T-scoreDisability IndexFinger/thumbCommon complicationDisease durationEULAR criteriaIschemic manifestationsAcro-osteolysisMultivariable analysisPhysical examinationHand functionClinical correlationHand dysfunctionClear historyHigh burdenBone densitometry