2022
Myometrial‐derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in mice
Zhang L, Mamillapalli R, Habata S, McAdow M, Taylor HS. Myometrial‐derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in mice. Journal Of Cellular And Molecular Medicine 2022, 26: 2566-2578. PMID: 35318804, PMCID: PMC9077289, DOI: 10.1111/jcmm.17252.Peer-Reviewed Original ResearchConceptsInflammation-related cytokinesSmooth muscle cellsPreterm laborCXCL12/CXCR4Preterm birthMacrophage migrationIL-6M1 polarizationPregnant miceImmune cellsCXCL12/CXCR4 axisTreatment of SMCsTumor necrosis factor alphaInduced preterm laborInfiltration of neutrophilsMacrophage M1 polarizationStart of labourNecrosis factor alphaTNF-α expressionPrimary smooth muscle cellsPremature laborPregnancy durationGestational tissuesMacrophage infiltrationNeonatal mortality
2016
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing
Thomer L, Emolo C, Thammavongsa V, Kim H, McAdow M, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Journal Of Experimental Medicine 2016, 213: 293-301. PMID: 26880578, PMCID: PMC4813671, DOI: 10.1084/jem.20150074.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusBloodstream infectionsPhagocytic killingElicit cross-protective immune responsesCross-protective immune responsesProtective fibrin shieldS. aureus vaccineAureus vaccineClinical efficacyMRSA isolatesImmune cellsOpsonophagocytic killingFrequent causeImmune responseHost immunityHost prothrombinProtective antigenSpecific antibodiesInfectionSurface moleculesAntibodiesS. aureusStaphylococcus aureusAntibody therapeuticsStaphylococcal surface
2012
Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections
McAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections. Journal Of Innate Immunity 2012, 4: 141-148. PMID: 22222316, PMCID: PMC3388267, DOI: 10.1159/000333447.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFormation of abscessesDrug-resistant S. aureusHost immune cellsHospital-acquired infectionsFactor binding proteinInnate defense mechanismsVon Willebrand factorThromboembolic lesionsClotting of plasmaPreclinical evidenceLethal sepsisImmune cellsStaphylococcal infectionsDisease pathogenesisCoagulation productsClinical isolatesCurrent epidemicKey innate defence mechanismCoagulation cascadeStaphylococcal productsInfectionWillebrand factorOpsonophagocytic clearanceHost infectionFibrin meshwork
2010
Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity. PLOS Pathogens 2010, 6: e1001036. PMID: 20700445, PMCID: PMC2916881, DOI: 10.1371/journal.ppat.1001036.Peer-Reviewed Original ResearchConceptsSpecific antibodiesFormation of abscessesHost immune cellsStaphylococcus aureus diseaseVon Willebrand factorProtective immunityAbscess formationStaphylococcal vaccineImmune cellsLethal bacteremiaNon-proteolytic activationAbscessCleavage of fibrinogenProtective antigenWillebrand factorS. aureusStaphylococcus aureusPseudocapsuleHistochemical stainingAntibodiesProthrombinHost tissuesCoagulaseVWbpAureus