2012
Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections
McAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections. Journal Of Innate Immunity 2012, 4: 141-148. PMID: 22222316, PMCID: PMC3388267, DOI: 10.1159/000333447.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFormation of abscessesDrug-resistant S. aureusHost immune cellsHospital-acquired infectionsFactor binding proteinInnate defense mechanismsVon Willebrand factorThromboembolic lesionsClotting of plasmaPreclinical evidenceLethal sepsisImmune cellsStaphylococcal infectionsDisease pathogenesisCoagulation productsClinical isolatesCurrent epidemicKey innate defence mechanismCoagulation cascadeStaphylococcal productsInfectionWillebrand factorOpsonophagocytic clearanceHost infectionFibrin meshwork
2010
Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity. PLOS Pathogens 2010, 6: e1001036. PMID: 20700445, PMCID: PMC2916881, DOI: 10.1371/journal.ppat.1001036.Peer-Reviewed Original ResearchConceptsSpecific antibodiesFormation of abscessesHost immune cellsStaphylococcus aureus diseaseVon Willebrand factorProtective immunityAbscess formationStaphylococcal vaccineImmune cellsLethal bacteremiaNon-proteolytic activationAbscessCleavage of fibrinogenProtective antigenWillebrand factorS. aureusStaphylococcus aureusPseudocapsuleHistochemical stainingAntibodiesProthrombinHost tissuesCoagulaseVWbpAureus