2022
Progress in surgical interventions for aortic root aneurysms and dissections
Parameswaran S, Ziganshin BA, Zafar M, Elefteriades JA. Progress in surgical interventions for aortic root aneurysms and dissections. Expert Review Of Cardiovascular Therapy 2022, 20: 65-79. PMID: 35037567, DOI: 10.1080/14779072.2022.2029702.Peer-Reviewed Original ResearchMeSH KeywordsAortaAortic Aneurysm, ThoracicAortic DissectionAortic ValveAortic Valve InsufficiencyHeart Valve Prosthesis ImplantationHumansTreatment OutcomeConceptsAortic root aneurysmRoot aneurysmAortic root replacement surgeryAortic root surgeryAortic valve leafletsValve dysfunctionAortic dissectionAortic pathologyProgressive dilatationSurgical optionsAneurysmal diseaseSurgical interventionCoronary arteryRoot surgeryAortic rootAortic tubeReplacement surgerySurgical investigationAnatomic patternsPubMed databaseRisk profileValve leafletsSystematic searchSurgeryAneurysms
2020
Cine-Computed Tomography for the Evaluation of Prosthetic Heart Valve Function
Hsu C, Bourganos K, Zafar MA, Huber S, Buntin J, Ziganshin BA, Mojibian H, Elefteriades JA. Cine-Computed Tomography for the Evaluation of Prosthetic Heart Valve Function. Cardiology 2020, 145: 439-445. PMID: 32454507, DOI: 10.1159/000507182.Peer-Reviewed Original ResearchConceptsAortic valve replacementAortic stenosisTransvalvular velocityValve functionECG-gated computed tomographyProsthetic heart valve functionProsthetic valve dysfunctionProsthetic valve functionCine CTHeart valve functionAVR patientsValve thrombosisCardiac eventsRepeat surgeryValve dysfunctionValve replacementSingle surgeonSurgical interventionRepeat evaluationProsthetic valvesComputed tomographyLeaflet excursionFurther evaluationLeaflet functionPatientsNonusefulness of Antithrombotic Therapy After Surgical Bioprosthetic Aortic Valve Replacement
Gryaznov AA, Saeyeldin A, Abdelbaky M, Zafar MA, Tanweer M, Papanikolaou D, Imran M, Li Y, Ziganshin BA, Elefteriades JA. Nonusefulness of Antithrombotic Therapy After Surgical Bioprosthetic Aortic Valve Replacement. The American Journal Of Cardiology 2020, 129: 71-78. PMID: 32605717, DOI: 10.1016/j.amjcard.2020.05.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnticoagulantsAortic ValveAortic Valve InsufficiencyAortic Valve StenosisAspirinAtrial FibrillationBicuspid Aortic Valve DiseaseBioprosthesisCoronary Artery DiseaseFactor Xa InhibitorsFemaleHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemorrhageHumansKaplan-Meier EstimateMaleMiddle AgedMortalityPlatelet Aggregation InhibitorsPostoperative CareProportional Hazards ModelsPurinergic P2Y Receptor AntagonistsStrokeThromboembolismWarfarinYoung AdultConceptsAortic valve replacementBiological aortic valve replacementAntithrombotic regimensValve replacementSurgical bioprosthetic aortic valve replacementCox proportional hazards regression modelSurgical aortic valve replacementBioprosthetic aortic valve replacementConsecutive adult patientsCoronary artery diseaseKaplan-Meier analysisIncidence of deathHazards regression modelsAntiplatelet groupAVR patientsRoutine anticoagulationAntithrombotic therapyCardiovascular eventsThromboembolic eventsAdult patientsAdverse eventsAnticoagulation groupArtery diseaseTreatment regimensTherapy group
2018
Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass
Gryaznov AA, Saeyeldin A, Abdelbaky M, Zafar MA, Tanweer M, Imran M, Papanikolaou D, Erben Y, Zefirova J, Ziganshin BA, Elefteriades JA. Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass. Cardiology 2018, 140: 213-221. PMID: 30138919, DOI: 10.1159/000490924.Peer-Reviewed Original ResearchConceptsAortic valve replacementValve replacementAortic stenosisSurgical aortic valve replacementBioprosthetic aortic valve replacementCommon valvular disorderImpact of anticoagulationSymptomatic aortic stenosisHigh-risk patientsValvular heart diseaseCommon pathologic conditionsAntithrombotic therapyMultiple comorbiditiesPerioperative complicationsRemote complicationsSurgical managementEndovascular interventionHeart diseaseValvular disordersBiological valvesLower riskEuropean guidelinesPathologic conditionsComplicationsStenosis
2012
Are Thromboembolic and Bleeding Complications a Drawback for Composite Aortic Root Replacement?
Zafar MA, Farkas EA, Javier A, Anderson M, Gilani O, Elefteriades JA. Are Thromboembolic and Bleeding Complications a Drawback for Composite Aortic Root Replacement? The Annals Of Thoracic Surgery 2012, 94: 737-743. PMID: 22626762, DOI: 10.1016/j.athoracsur.2012.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceAortic ValveBioprosthesisCirculatory Arrest, Deep Hypothermia InducedCohort StudiesFemaleHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedPostoperative ComplicationsPostoperative HemorrhagePrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSafety ManagementSurvival AnalysisThromboembolismTreatment OutcomeUltrasonographyConceptsComposite aortic root replacementAortic root replacementComposite graft replacementAortic root reconstructionRoot replacementGraft replacementRoot reconstructionValve-preserving aortic root reconstructionSocial Security Death IndexSex-matched populationKaplan-Meier curvesMechanical valve conduitBleeding complicationsHospital mortalityDistal embolismLatest followAortic databaseBiologic conduitDeath IndexPatient interviewsMinimal morbidityAortic rootExcellent survivalNative valveValve conduits