2023
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteria
2021
Root Dilatation Is More Malignant Than Ascending Aortic Dilation
Kalogerakos PD, Zafar MA, Li Y, Mukherjee SK, Ziganshin BA, Rizzo JA, Elefteriades JA. Root Dilatation Is More Malignant Than Ascending Aortic Dilation. Journal Of The American Heart Association 2021, 10: e020645. PMID: 34238012, PMCID: PMC8483477, DOI: 10.1161/jaha.120.020645.Peer-Reviewed Original ResearchConceptsMid-ascending aortaAortic rootAdverse eventsRoot dilatationNatural historyAcute aortic dissectionLong-term complicationsAortic root dilatationSignificant higher riskThoracic aortic aneurysmSerious risk factorAortic interventionAortic dilatationAortic dilationAortic dissectionAortic aneurysmInternational registryRisk factorsAortic segmentsGuideline criteriaHigh riskExpert centersAortaShort statureResult diameters
2019
A systematic review and meta-analysis of isolated abdominal aortic dissection
Wu J, Zafar M, Qiu J, Huang Y, Chen Y, Yu C, Elefteriades JA. A systematic review and meta-analysis of isolated abdominal aortic dissection. Journal Of Vascular Surgery 2019, 70: 2046-2053.e6. PMID: 31204217, DOI: 10.1016/j.jvs.2019.04.467.Peer-Reviewed Original ResearchConceptsIsolated abdominal aortic dissectionType B aortic dissectionAbdominal aortic dissectionAortic dissectionB aortic dissectionPrevalent risk factorsRisk factorsAverage aortic diameterComplication-specific approachEndovascular aortic repairAbdominal painChest painLate mortalityAortic repairClinical characteristicsConservative managementBack painPooled prevalenceRenal arteryAbdominal examinationAortic diameterAortic diseaseClinical symptomsCommon symptomsOpen surgery
2016
Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm
Prasad K, Sarkar A, Zafar MA, Shoker A, Moselhi HE, Tranquilli M, Ziganshin BA, Elefteriades JA. Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm. Aorta 2016, 04: 1-10. PMID: 27766267, PMCID: PMC5068493, DOI: 10.12945/j.aorta.2015.15.018.Peer-Reviewed Original ResearchAdvanced glycation end productsEndogenous secretory RAGEThoracic aortic aneurysmGlycation end productsMatrix metalloproteinasesSerum sRAGEAortic aneurysmSoluble receptorFormation of TAALevels of AGEsPathogenesis of TAALevels of sRAGEAGE-RAGE axisLevels of cytokinesProduction of cytokinesRelease of cytokinesAGEs/Control subjectsRisk factorsStudy populationSRAGEBlood samplesMMP-2CytokinesELISA kit
2012
Carotid Intima-Media Thickness Provides Evidence that Ascending Aortic Aneurysm Protects against Systemic Atherosclerosis
Hung A, Zafar M, Mukherjee S, Tranquilli M, Scoutt LM, Elefteriades JA. Carotid Intima-Media Thickness Provides Evidence that Ascending Aortic Aneurysm Protects against Systemic Atherosclerosis. Cardiology 2012, 123: 71-77. PMID: 23006774, DOI: 10.1159/000341234.Peer-Reviewed Original ResearchConceptsIntima-media thicknessCarotid intima-media thicknessAortic aneurysmCalcium scoreAortic calcium scoreAverage intima-media thicknessAortic aneurysm patientsCarotid IMT valuesDegree of atherosclerosisPositive family historyAortic aneurysm developmentDevelopment of atherosclerosisCommon carotid arterySystemic atherosclerosisAneurysm patientsIMT valuesMale genderRisk factorsCarotid arteryFamily historyMultiple linear regression analysisAtherosclerosisEarly markerAneurysm developmentAneurysms