2023
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteria
2022
Rapid growth of thoracic aortic aneurysm: Reality or myth?
Sonsino A, Ellauzi H, Ziganshin BA, Zafar MA, Elefteriades JA. Rapid growth of thoracic aortic aneurysm: Reality or myth? Journal Of Thoracic And Cardiovascular Surgery 2022, 167: 1206-1213. PMID: 36028356, DOI: 10.1016/j.jtcvs.2022.06.021.Peer-Reviewed Original ResearchRapid aortic growthAortic growthAortic growth rateProphylactic surgical interventionThoracic aortic aneurysmPrompt surgeryInoperable patientsAortic diseaseSurgical interventionAortic measurementsAortic aneurysmPositivity ratePatientsAortaExperienced cliniciansGenetic findingsAortic imagesAneurysmsAmerican AssociationPotential sourceSurgeryAscendingCliniciansDiseaseSurvivors
2018
Diabetes Mellitus: Is It Protective against Aneurysm? A Narrative Review
Patel K, Zafar MA, Ziganshin BA, Elefteriades JA. Diabetes Mellitus: Is It Protective against Aneurysm? A Narrative Review. Cardiology 2018, 141: 107-122. PMID: 30453299, DOI: 10.1159/000490373.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmAortic aneurysmDiabetic patientsAortic dissectionDipeptidyl peptidase-4 inhibitorsCommon antidiabetic medicationsPrevalence of TAAsPeptidase-4 inhibitorsAneurysm growth rateSmaller aneurysm diameterAortic wall stressRate of mortalityLow rupture ratesAntidiabetic medicationsAortic surgeryHospital stayDiabetic stateAortic growthAneurysm diameterAntidiabetic agentsDecreased lengthAneurysmsProtective roleRupture rateMatrix metalloproteinases