Influenza Virus-Induced Oxidized DNA Activates Inflammasomes
Moriyama M, Nagai M, Maruzuru Y, Koshiba T, Kawaguchi Y, Ichinohe T. Influenza Virus-Induced Oxidized DNA Activates Inflammasomes. IScience 2020, 23: 101270. PMID: 32592999, PMCID: PMC7293844, DOI: 10.1016/j.isci.2020.101270.Peer-Reviewed Original ResearchPB1-F2 proteinOxidized DNAViral proteinsMitochondrial reactive oxygen species productionDNA releaseInfluenza virus M2IL-1β secretionMitochondrial ROS productionIon channel activityReactive oxygen species productionMitochondrial localizationIntracellular ionic balanceAntioxidant Mito-TEMPOOxygen species productionNLRP3 inflammasome activationVirus M2Inflammasome activationM2 proteinReceptor familyNOD-like receptor familyProteinInfluenza viral proteinsMito-TEMPOChannel activityROS production