2021
The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity
van Galen KA, Booij J, Schrantee A, Adriaanse SM, Unmehopa UA, Fliers E, Schwartz GJ, DiLeone RJ, Horst K, la Fleur SE, Serlie MJ. The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity. Metabolism 2021, 123: 154839. PMID: 34331964, PMCID: PMC8994212, DOI: 10.1016/j.metabol.2021.154839.Peer-Reviewed Original ResearchConceptsStriatal DAT availabilityLean menSERT availabilityDAT availabilityThalamic serotonin transportersSerotonin transporterDopaminergic systemTransporter availabilityStriatal dopamine transporter availabilityPeripheral metabolic signalsFree fatty acid concentrationsCross-over trialSerotonin transporter availabilityFasting-induced increaseDopamine transporter availabilitySystemic energy metabolismHypothalamus/thalamusLean subjectsPlasma insulinFatty acid concentrationsStriatal DATFood intakeObesityInter-individual variationHigh inter-individual variation
2018
Striatal dopamine regulates systemic glucose metabolism in humans and mice
Ter Horst KW, Lammers NM, Trinko R, Opland DM, Figee M, Ackermans MT, Booij J, van den Munckhof P, Schuurman PR, Fliers E, Denys D, DiLeone RJ, la Fleur SE, Serlie MJ. Striatal dopamine regulates systemic glucose metabolism in humans and mice. Science Translational Medicine 2018, 10 PMID: 29794060, DOI: 10.1126/scitranslmed.aar3752.Peer-Reviewed Original ResearchConceptsSystemic glucose metabolismDeep brain stimulationPeripheral insulin sensitivityGlucose metabolismInsulin sensitivityStriatal dopamineBilateral deep brain stimulationStriatal neuronal activityPeripheral glucose metabolismReceptor-expressing neuronsStriatal dopamine signalingObservational human studiesNondiabetic patientsInsulin requirementsDopamine depletionGlucose toleranceObsessive-compulsive disorderDiabetes patientsInternal capsuleStriatal areasDopamine releaseHealthy subjectsAnterior limbNucleus accumbensNeuronal activity