2023
Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study
van Galen K, Schrantee A, ter Horst K, la Fleur S, Booij J, Constable R, Schwartz G, DiLeone R, Serlie M. Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. Nature Metabolism 2023, 5: 1059-1072. PMID: 37308722, DOI: 10.1038/s42255-023-00816-9.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossCerebral neuronal activityStriatal dopamine releaseWeight lossCrossover studyDopamine releaseNeuronal activityIntragastric glucoseNeuronal responsesSuccessful weight lossHealthy body weightSignificant weight lossBrain responsesPathological feeding behaviorsWeight regainHunger scoresLipid infusionLean participantsCaloric intakePlasma hormonesObesityBody weightInfusionNutrient signalsHigh rate
2018
Striatal dopamine regulates systemic glucose metabolism in humans and mice
Ter Horst KW, Lammers NM, Trinko R, Opland DM, Figee M, Ackermans MT, Booij J, van den Munckhof P, Schuurman PR, Fliers E, Denys D, DiLeone RJ, la Fleur SE, Serlie MJ. Striatal dopamine regulates systemic glucose metabolism in humans and mice. Science Translational Medicine 2018, 10 PMID: 29794060, DOI: 10.1126/scitranslmed.aar3752.Peer-Reviewed Original ResearchConceptsSystemic glucose metabolismDeep brain stimulationPeripheral insulin sensitivityGlucose metabolismInsulin sensitivityStriatal dopamineBilateral deep brain stimulationStriatal neuronal activityPeripheral glucose metabolismReceptor-expressing neuronsStriatal dopamine signalingObservational human studiesNondiabetic patientsInsulin requirementsDopamine depletionGlucose toleranceObsessive-compulsive disorderDiabetes patientsInternal capsuleStriatal areasDopamine releaseHealthy subjectsAnterior limbNucleus accumbensNeuronal activity