2019
Suppression of the Ubiquitin Pathway by Small Molecule Binding to Ubiquitin Enhances Doxorubicin Sensitivity of the Cancer Cells
Nguyen T, Ho M, Kim K, Yun S, Mizar P, Easton J, Lee S, Kim K. Suppression of the Ubiquitin Pathway by Small Molecule Binding to Ubiquitin Enhances Doxorubicin Sensitivity of the Cancer Cells. Molecules 2019, 24: 1073. PMID: 30893775, PMCID: PMC6471062, DOI: 10.3390/molecules24061073.Peer-Reviewed Original ResearchConceptsCongo redUbiquitin processing enzymesAnticancer drugsDiazo compoundsNovel anticancer drugsSmall moleculesActivity of ubiquitinNMR mappingDevelopment of inhibitorsSurface of ubiquitinConventional anticancer drugsMoleculesDruggabilityUbiquitin moleculesPromising strategyRecognition sitesProof of conceptCompoundsRedSensitizersHereinBindingBinding of ubiquitinChemicalsScaffolds
2016
An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors
Nguyen T, Ho M, Ghosh A, Kim T, Yun S, Lee S, Kim K. An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors. Biochemical And Biophysical Research Communications 2016, 479: 33-39. PMID: 27613091, DOI: 10.1016/j.bbrc.2016.09.010.Peer-Reviewed Original ResearchConceptsUbiquitin processing enzymesUbiquitin receptorsUbiquitin pathwayProcessing enzymesBinding of ubiquitinDiverse biological processesCancer cell migrationBiological roleBiological processesUbiquitinCell migrationEnzymatic activityInteracting surfacesCritical rolePathwayEnzymeRelated diseasesRelevant diseasesInhibitorsReceptorsBindsMoleculesRoleBindingInteraction