Suppression of the Ubiquitin Pathway by Small Molecule Binding to Ubiquitin Enhances Doxorubicin Sensitivity of the Cancer Cells
Nguyen T, Ho M, Kim K, Yun S, Mizar P, Easton J, Lee S, Kim K. Suppression of the Ubiquitin Pathway by Small Molecule Binding to Ubiquitin Enhances Doxorubicin Sensitivity of the Cancer Cells. Molecules 2019, 24: 1073. PMID: 30893775, PMCID: PMC6471062, DOI: 10.3390/molecules24061073.Peer-Reviewed Original ResearchConceptsCongo redUbiquitin processing enzymesAnticancer drugsDiazo compoundsNovel anticancer drugsSmall moleculesActivity of ubiquitinNMR mappingDevelopment of inhibitorsSurface of ubiquitinConventional anticancer drugsMoleculesDruggabilityUbiquitin moleculesPromising strategyRecognition sitesProof of conceptCompoundsRedSensitizersHereinBindingBinding of ubiquitinChemicalsScaffolds