2019
Efficacy and Mediators of a Group Cognitive–Behavioral Therapy for Hoarding Disorder: A Randomized Trial
Tolin DF, Wootton BM, Levy HC, Hallion LS, Worden BL, Diefenbach GJ, Jaccard J, Stevens MC. Efficacy and Mediators of a Group Cognitive–Behavioral Therapy for Hoarding Disorder: A Randomized Trial. Journal Of Consulting And Clinical Psychology 2019, 87: 590-602. PMID: 31008633, DOI: 10.1037/ccp0000405.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapyCognitive behavioral therapyBrief group cognitive-behavioural therapyEmotional distress toleranceProblem-solving trainingMotivational interviewing strategiesSubjective cognitive impairmentMaladaptive beliefsDistress tolerancePsychological treatmentHoarding DisorderHypothesized mediatorsTreatment outcomesSession practiceContingency managementCognitive impairmentSymptoms of HDGroup sessionsIndependent evaluatorsPsychiatric disordersTreatment conditionsWait listAdultsAdditional researchDisordersBrain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples
Hoogman M, Muetzel R, Guimaraes J, Shumskaya E, Mennes M, Zwiers M, Jahanshad N, Sudre G, Wolfers T, Earl E, Soliva Vila J, Vives-Gilabert Y, Khadka S, Novotny S, Hartman C, Heslenfeld D, Schweren L, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini T, Rosa P, Zanetti M, Malpas C, Kohls G, von Polier G, Seitz J, Biederman J, Doyle A, Dale A, van Erp T, Epstein J, Jernigan T, Baur-Streubel R, Ziegler G, Zierhut K, Schrantee A, Høvik M, Lundervold A, Kelly C, McCarthy H, Skokauskas N, O’Gorman Tuura R, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke K, Christakou A, Vance A, Cercignani M, Gabel M, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati I, Tovar-Moll F, Fallgatter A, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen K, Kuntsi J, Mehta M, Paloyelis Y, Harrison N, Bellgrove M, Silk T, Cubillo A, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos F, Yoncheva Y, Haavik J, Reneman L, Conzelmann A, Lesch K, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Busatto G, Louza M, Durston S, Hoekstra P, Oosterlaan J, Stevens M, Ramos-Quiroga J, Vilarroya O, Fair D, Nigg J, Thompson P, Buitelaar J, Faraone S, Shaw P, Tiemeier H, Bralten J, Franke B. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples. American Journal Of Psychiatry 2019, 176: 531-542. PMID: 31014101, PMCID: PMC6879185, DOI: 10.1176/appi.ajp.2019.18091033.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCortical measuresDeficit hyperactivity disorderChild Behavior ChecklistAdult groupAttention ScaleADHD symptomsAttention problemsCortical thicknessFusiform gyrusHyperactivity disorderADHD diagnosisCortical surface areaLifespan trajectoriesBehavior ChecklistFamilial effectsFuture longitudinal studiesTemporal regionsNeuroimage studiesBrain regionsLarge significant effectLow surface area valuesLongitudinal studyAdolescentsFrontal cortex
2018
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Kong XZ, Mathias SR, Guadalupe T, Glahn D, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher S, Thompson P, Francks C, Kong X, Mathias S, Guadalupe T, Abé C, Agartz I, Akudjedu T, Aleman A, Alhusaini S, Allen N, Ames D, Andreassen O, Vasquez A, Armstrong N, Bergo F, Bastin M, Batalla A, Bauer J, Baune B, Baur-Streubel R, Biederman J, Blaine S, Boedhoe P, Bøen E, Bose A, Bralten J, Brandeis D, Brem S, Brodaty H, Yüksel D, Brooks S, Buitelaar J, Bürger C, Bülow R, Calhoun V, Calvo A, Canales-Rodríguez E, Canive J, Cannon D, Caparelli E, Castellanos F, Cavalleri G, Cendes F, Chaim-Avancini T, Chantiluke K, Chen Q, Chen X, Cheng Y, Christakou A, Clark V, Coghill D, Connolly C, Conzelmann A, Córdova-Palomera A, Cousijn J, Crow T, Cubillo A, Dale A, Dannlowski U, Ambrosino de Bruttopilo S, de Zeeuw P, Deary I, Delanty N, Demeter D, Di Martino A, Dickie E, Dietsche B, Doan N, Doherty C, Doyle A, Durston S, Earl E, Ehrlich S, Ekman C, Elvsåshagen T, Epstein J, Fair D, Faraone S, Fernández G, Filho G, Förster K, Fouche J, Foxe J, Frodl T, Fuentes-Claramonte P, Fullerton J, Garavan H, Garcia D, Gotlib I, Goudriaan A, Grabe H, Groenewold N, Grotegerd D, Gruber O, Gurholt T, Haavik J, Hahn T, Hansell N, Harris M, Hartman C, Hernández M, Heslenfeld D, Hester R, Hibar D, Ho B, Ho T, Hoekstra P, van Holst R, Hoogman M, Høvik M, Howells F, Hugdahl K, Huyser C, Ingvar M, Irwin L, Ishikawa A, James A, Jahanshad N, Jernigan T, Jönsson E, Kähler C, Kaleda V, Kelly C, Kerich M, Keshavan M, Khadka S, Kircher T, Kohls G, Konrad K, Korucuoglu O, Krämer B, Krug A, Kwon J, Lambregts-Rommelse N, Landén M, Lázaro L, Lebedeva I, Lenroot R, Lesch K, Li Q, Lim K, Liu J, Lochner C, London E, Lonning V, Lorenzetti V, Luciano M, Luijten M, Lundervold A, Mackey S, MacMaster F, Maingault S, Malpas C, Malt U, Mataix-Cols D, Martin-Santos R, Mayer A, McCarthy H, Mitchell P, Mueller B, Maniega S, Mazoyer B, McDonald C, McLellan Q, McMahon K, McPhilemy G, Momenan R, Morales A, Narayanaswamy J, Moreira J, Nerland S, Nestor L, Newman E, Nigg J, Nordvik J, Novotny S, Weiss E, O’Gorman R, Oosterlaan J, Oranje B, Orr C, Overs B, Pauli P, Paulus M, Plessen K, von Polier G, Pomarol-Clotet E, Portella M, Qiu J, Radua J, Ramos-Quiroga J, Reddy Y, Reif A, Roberts G, Rosa P, Rubia K, Sacchet M, Sachdev P, Salvador R, Schmaal L, Schulte-Rüther M, Schweren L, Seidman L, Seitz J, Serpa M, Shaw P, Shumskaya E, Silk T, Simmons A, Simulionyte E, Sinha R, Sjoerds Z, Smelror R, Soliva J, Solowij N, Souza-Duran F, Sponheim S, Stein D, Stein E, Stevens M, Strike L, Sudre G, Sui J, Tamm L, Temmingh H, Thoma R, Tomyshev A, Tronchin G, Turner J, Uhlmann A, van Erp T, van den Heuvel O, van der Meer D, van Eijk L, Vance A, Veer I, Veltman D, Venkatasubramanian G, Vilarroya O, Vives-Gilabert Y, Voineskos A, Völzke H, Vuletic D, Walitza S, Walter H, Walton E, Wardlaw J, Wen W, Westlye L, Whelan C, White T, Wiers R, Wright M, Wittfeld K, Yang T, Yasuda C, Yoncheva Y, Yücel M, Yun J, Zanetti M, Zhen Z, Zhu X, Ziegler G, Zierhut K, de Zubicaray G, Zwiers M, Glahn D, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher S, Thompson P, Francks C, Farde L, Flyckt L, Engberg G, Erhardt S, Fatouros-Bergman H, Cervenka S, Schwieler L, Piehl F, Agartz I, Collste K, Victorsson P, Malmqvist A, Hedberg M, Orhan F. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e5154-e5163. PMID: 29764998, PMCID: PMC5984496, DOI: 10.1073/pnas.1718418115.Peer-Reviewed Original ResearchConceptsBrain asymmetryCortical thicknessHealthy individualsAltered brain asymmetryCerebral cortical asymmetryENIGMA consortiumTransverse temporal gyrusPopulation-level asymmetriesInferior frontal gyrusPsychiatric disordersMRI scansParahippocampal gyrusCardinal featuresSignificant associationIntracranial volumeNeuropsychiatric disordersTemporal gyrusThicker cortexFrontal gyrusCortical asymmetryHuman brain organizationLeft hemisphereGyrusLateralized functionsBrain organization
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatientsNeurofunctional Reward Processing Changes in Cocaine Dependence During Recovery
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Carroll KM, Potenza MN. Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 2016, 41: 2112-2121. PMID: 26792441, PMCID: PMC4908642, DOI: 10.1038/npp.2016.11.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus activityCD participantsNegative urine screensReward/loss processingHealthy control participantsReward processingMeaningful outcome indicatorsDopamine-innervated regionsFunctional magnetic resonanceInferior frontal gyrus activityCD outpatientsTest-retest resultsPrefrontal cortex activityVentromedial prefrontal cortex activityUrine screensNeurofunctional alterationsVentral striatal activityCD groupNeurofunctional changesLong-term recoveryDrug useNeurobiological changesCocaine abstinenceCocaine dependenceStriatal activity
2013
Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Biological Psychiatry 2013, 76: 456-465. PMID: 24439302, PMCID: PMC5045030, DOI: 10.1016/j.biopsych.2013.12.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSlow beta activityFast alpha activitySZ probandsAlpha activityHealthy control subjectsBeta activityRelative risk estimatesFrontal delta activityEEG spectral activityModerate relative riskPsychotic bipolar patientsLow-frequency activityPsychotic bipolar probandsGroup independent component analysisControl subjectsRelative riskPost-hoc pair-wise comparisonsBipolar patientsGenetic predispositionIntermediate Phenotypes (B-SNIP) studyOscillatory abnormalitiesAnalysis of covarianceUnique endophenotypesBipolar disorderHoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Research 2013, 221: 142-148. PMID: 24389161, PMCID: PMC3946244, DOI: 10.1016/j.pscychresns.2013.11.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGo/NoGo taskFunctional magnetic resonance imagingOCD patientsHD patientsResponse inhibitionNoGo taskHealthy controlsGo/NoGo task performanceDistinct neural underpinningsRight orbitofrontal gyrusErrors of commissionNeural underpinningsOrbitofrontal activationTask performanceCorrect rejectsMagnetic resonance imagingHemodynamic activityFrontal hypoactivityNeural activityOrbitofrontal gyrusBehavioral dataHemodynamic responsePatientsPreliminary evidenceA pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder
Balodis IM, Grilo CM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Potenza MN. A pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder. International Journal Of Eating Disorders 2013, 47: 376-384. PMID: 24729034, PMCID: PMC3986812, DOI: 10.1002/eat.22204.Peer-Reviewed Original ResearchConceptsBinge-eating disorderFunctional magnetic resonance imagingReward processingMonetary incentive delay taskInferior frontal gyrusIncentive delay taskBinge-eating statusMedial prefrontal cortexBrain reward circuitryNeural correlatesDelay taskSpecific brain regionsFrontal gyrusNeurobiological underpinningsOutcome phasePrefrontal cortexReward circuitryVentral striatumAnticipatory phaseBrain regionsTreatment outcomesDiminished recruitmentProcessingMagnetic resonance imagingIndividualsError processing in current and former cocaine users
Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging And Behavior 2013, 8: 87-96. PMID: 23949893, PMCID: PMC3925762, DOI: 10.1007/s11682-013-9247-y.Peer-Reviewed Original ResearchConceptsFormer cocaine usersError processingSupramarginal gyrusCocaine usersBOLD responseRight inferior parietal lobuleAspects of impulsivityAbstinent cocaine usersCocaine abuse/dependenceInferior parietal lobuleCocaine-dependent individualsCurrent cocaine usersCognitive compensationNeural differencesPrepotent responsesResponse inhibitionAbuse/dependenceCorrect rejectionsSpecific deficitsBOLD activityTrait measuresMaladaptive behaviorsParietal lobuleAddictive behaviorsNeural activityA large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task
Steele VR, Aharoni E, Munro GE, Calhoun VD, Nyalakanti P, Stevens MC, Pearlson G, Kiehl KA. A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task. Behavioural Brain Research 2013, 256: 529-536. PMID: 23756137, PMCID: PMC4437665, DOI: 10.1016/j.bbr.2013.06.001.Peer-Reviewed Original ResearchConceptsSuccessful response inhibitionGo/NoGo taskResponse inhibitionUnsuccessful response inhibitionMagnetic resonance imaging studySupplementary motor areaResonance imaging studyFunctional magnetic resonance imaging studyInferior parietal lobuleNoGo taskInferior prefrontal regionsHealthy adult participantsBasal gangliaInferior frontal gyrusHemodynamic responseMotor areaAnterior cingulateImaging studiesParietal lobuleFronto-parietal networkHemodynamic activityFrontal gyrusFrontostriatal regionsSmall sample studiesPrefrontal regionsMonetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder
Balodis IM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Sinha R, Grilo CM, Potenza MN. Monetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder. Biological Psychiatry 2013, 73: 877-886. PMID: 23462319, PMCID: PMC3686098, DOI: 10.1016/j.biopsych.2013.01.014.Peer-Reviewed Original ResearchConceptsReward/loss processingReward processingLoss processingVentromedial prefrontal cortex activityFunctional magnetic resonance imagingMonetary reward processingPrefrontal cortex activityBinge Eating DisorderVentral striatal activityNeural differencesNeural correlatesLoss taskLoss prospectsNeurobiological underpinningsCortex activityEating DisordersRegional activationVentral striatumBED groupAnticipatory phaseStriatal activityProcessingIndividualsOB groupObese individuals
2012
Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample
Cope LM, Shane MS, Segall JM, Nyalakanti PK, Stevens MC, Pearlson GD, Calhoun VD, Kiehl KA. Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample. Psychiatry Research 2012, 204: 91-100. PMID: 23217577, PMCID: PMC3536442, DOI: 10.1016/j.pscychresns.2012.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderBrainCognition DisordersFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve Fibers, MyelinatedNeuropsychological TestsPersonality InventoryPsychiatric Status Rating ScalesRegression AnalysisResidence CharacteristicsSubstance-Related DisordersConceptsGray matter volumeMatter volumeOrbital frontal cortexMagnetic resonance imagingRight hippocampusFrontal cortexBilateral orbital frontal cortexRight anterior cingulateGray matter reductionsGray matter increasesStructural imaging studiesLimbic regionsBrain abnormalitiesRight insulaParalimbic regionsAnterior cingulateLifetime drugSubstance abuse sampleResonance imagingImaging studiesAlcohol useExploratory regression analysisRegression analysisLimbicMatter reductionExposure therapy, D-cycloserine, and functional magnetic resonance imaging in patients with snake phobia: a randomized pilot study.
Nave AM, Tolin DF, Stevens MC. Exposure therapy, D-cycloserine, and functional magnetic resonance imaging in patients with snake phobia: a randomized pilot study. The Journal Of Clinical Psychiatry 2012, 73: 1179-86. PMID: 23059145, DOI: 10.4088/jcp.11m07564.Peer-Reviewed Original ResearchConceptsExposure therapyD-cycloserinePhobic stimuliSnake phobiaFunctional magnetic resonance imaging (fMRI) taskRight dorsolateral prefrontal cortexPrefrontal brain activationPrefrontal cortex responsesD-cycloserine augmentationAnterior cingulate activationFunctional magnetic resonanceDorsolateral prefrontal cortexHuman brain functionDifferent neural pathwaysFear extinctionSnake stimuliExposure hierarchyNeural substratesBrain activationCingulate activationNeural responsesEmotional learningPrefrontal cortexCortex responsesPerigenual cingulateNeural Mechanisms of Decision Making in Hoarding Disorder
Tolin DF, Stevens MC, Villavicencio AL, Norberg MM, Calhoun VD, Frost RO, Steketee G, Rauch SL, Pearlson GD. Neural Mechanisms of Decision Making in Hoarding Disorder. JAMA Psychiatry 2012, 69: 832-841. PMID: 22868937, PMCID: PMC3506167, DOI: 10.1001/archgenpsychiatry.2011.1980.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral CortexDecision MakingDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsExpressed EmotionFemaleGyrus CinguliHoarding DisorderHospitals, VoluntaryHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysObsessive BehaviorSickness Impact ProfileConceptsHealthy control subjectsObsessive-compulsive disorderAnterior cingulate cortexNeural mechanismsCingulate cortexBrain regionsNeural activityAppropriate emotional responsesFrontal brain regionsFunctional magnetic resonance imaging (fMRI) signalsPrevious neuroimaging studiesUnique diagnostic entityFunctional magnetic resonanceMagnetic resonance imaging signalsControl subjectsImpaired decisionInsula functionEmotional significanceAffective statesDepressive symptomsHoarding DisorderEmotional responsesNeuroimaging studiesPatientsPoor insightDefault mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regionsNeural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder
Ethridge LE, Hamm JP, Shapiro JR, Summerfelt AT, Keedy SK, Stevens MC, Pearlson G, Tamminga CA, Boutros NN, Sweeney JA, Keshavan MS, Thaker G, Clementz BA. Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder. Biological Psychiatry 2012, 72: 766-774. PMID: 22572033, PMCID: PMC3465513, DOI: 10.1016/j.biopsych.2012.03.034.Peer-Reviewed Original ResearchConceptsAuditory oddball taskBipolar disorderNeural responsesBest differentiated groupsSingular time pointsDifferent psychotic disordersAuditory processing abnormalitiesOddball taskPsychotic bipolar disorderP300 event-related potentialNonpsychotic patientsHealthy subjectsPsychotic disordersPsychosis groupAuditory oddball responsePsychotic groupSchizophreniaFrequent combinationTime pointsBrain activationNeural activationBeta activityGroup differencesBrain responsesDisordersMultiple resting state network functional connectivity abnormalities in mild traumatic brain injury
Stevens MC, Lovejoy D, Kim J, Oakes H, Kureshi I, Witt ST. Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury. Brain Imaging And Behavior 2012, 6: 293-318. PMID: 22555821, DOI: 10.1007/s11682-012-9157-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMild traumatic brain injuryMild TBI patientsFunctional connectivity abnormalitiesTBI patientsBrain injuryConnectivity abnormalitiesFunctional connectivitySevere traumatic brain injuryWhite matter microstructural damagePostconcussive symptom severityWhole-brain functional connectivityFunctional connectivity deficitsCompensatory neural processesBrain networksBrain functional connectivityHealthy control participantsVoxelwise group comparisonsIntracerebral injuryNeurobiological sequelaeConnectivity deficitsAnterior cingulateBrain regionsSymptom severityAnatomical connectivityDifferences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives
Meda SA, Gill A, Stevens MC, Lorenzoni RP, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, Thaker G, Pearlson GD. Differences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives. Biological Psychiatry 2012, 71: 881-889. PMID: 22401986, PMCID: PMC3968680, DOI: 10.1016/j.biopsych.2012.01.025.Peer-Reviewed Original ResearchConceptsUnaffected first-degree relativesFirst-degree relativesPsychotic bipolar probandsBipolar probandsNegative Syndrome Scale (PANSS) scoresBipolar disorder shareFunctional brain dysconnectivityIndividual resting-state networksFunctional network connectivity analysisPANSS negative scoresResting-state networksFunctional network connectivityFunctional magnetic resonanceControl subjectsBrain dysconnectivityDisorder sharesHealthy subjectsBipolar relativesParalimbic circuitsScale scoreConnectivity differencesClinical relationshipSchizophreniaAbnormal pairsProbandsDiminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Potenza MN. Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling. Biological Psychiatry 2012, 71: 749-757. PMID: 22336565, PMCID: PMC3460522, DOI: 10.1016/j.biopsych.2012.01.006.Peer-Reviewed Original ResearchConceptsAlcohol dependencePathological gamblingVentral striatumMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studyBrain activation changesMonetary incentive delay taskReward processingLoss processingPresent functional magnetic resonance imaging (fMRI) studyControl comparison groupIncentive delay taskVentral striatal activationPG groupMonetary rewardsVentromedial prefrontal cortexSimilar associationImaging studiesFrontostriatal activityLoss anticipationConsistent alterationsActivation changesPrefrontal cortexLevels of impulsivity
2011
Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis
Hamm JP, Ethridge LE, Shapiro JR, Stevens MC, Boutros NN, Summerfelt AT, Keshavan MS, Sweeney JA, Pearlson G, Tamminga CA, Thaker G, Clementz BA. Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. Psychophysiology 2011, 49: 522-530. PMID: 22176721, PMCID: PMC3309114, DOI: 10.1111/j.1469-8986.2011.01327.x.Peer-Reviewed Original Research