2015
A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers
Worhunsky PD, Dager AD, Meda SA, Khadka S, Stevens MC, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Potenza MN, Pearlson GD. A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers. Neuropsychopharmacology 2015, 41: 1637-1647. PMID: 26514582, PMCID: PMC4832027, DOI: 10.1038/npp.2015.332.Peer-Reviewed Original ResearchConceptsAlcohol useYoung adult drinkersYoung adultsPreliminary prospective studyAdult drinkersExcessive alcohol useAlcohol use disorderFunctional network activityProspective studyUse disordersFunctional brain networksGo/No-Go taskNeurobiological alterationsDomain scoresGreater riskDaily drinksAddictive disordersDrinkersDrinking occasionsLongitudinal studyFronto-parietal circuitryBrain networks
2014
Genetic association of impulsivity in young adults: a multivariate study
Khadka S, Narayanan B, Meda SA, Gelernter J, Han S, Sawyer B, Aslanzadeh F, Stevens MC, Hawkins KA, Anticevic A, Potenza MN, Pearlson GD. Genetic association of impulsivity in young adults: a multivariate study. Translational Psychiatry 2014, 4: e451-e451. PMID: 25268255, PMCID: PMC4199418, DOI: 10.1038/tp.2014.95.Peer-Reviewed Original Research
2013
Error processing in current and former cocaine users
Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging And Behavior 2013, 8: 87-96. PMID: 23949893, PMCID: PMC3925762, DOI: 10.1007/s11682-013-9247-y.Peer-Reviewed Original ResearchConceptsFormer cocaine usersError processingSupramarginal gyrusCocaine usersBOLD responseRight inferior parietal lobuleAspects of impulsivityAbstinent cocaine usersCocaine abuse/dependenceInferior parietal lobuleCocaine-dependent individualsCurrent cocaine usersCognitive compensationNeural differencesPrepotent responsesResponse inhibitionAbuse/dependenceCorrect rejectionsSpecific deficitsBOLD activityTrait measuresMaladaptive behaviorsParietal lobuleAddictive behaviorsNeural activityRobust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task
Patel KT, Stevens MC, Meda SA, Muska C, Thomas AD, Potenza MN, Pearlson GD. Robust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task. Biological Psychiatry 2013, 74: 529-537. PMID: 23778289, PMCID: PMC3775945, DOI: 10.1016/j.biopsych.2013.04.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticipation, PsychologicalBrainBrain MappingCocaine-Related DisordersFemaleHumansImpulsive BehaviorMagnetic Resonance ImagingMaleRewardConceptsMonetary incentive delay taskVentral tegmental areaHealthy subjectsFormer cocaine usersLoss anticipationIncentive delay taskCocaine usersTegmental areaLoss outcomesCurrent cocaine usersDrug useAbnormal brain activation patternsCocaine addictionCurrent usersActivation patternsCocaine-using groupDelay taskLong-term cocaine abstinenceFunctional magnetic resonanceSubstance-induced alterationsBrain activation patternsCircuit abnormalitiesAnterior cingulate activationControl subjectsRisk factors
2012
Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Potenza MN. Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling. Biological Psychiatry 2012, 71: 749-757. PMID: 22336565, PMCID: PMC3460522, DOI: 10.1016/j.biopsych.2012.01.006.Peer-Reviewed Original ResearchConceptsAlcohol dependencePathological gamblingVentral striatumMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studyBrain activation changesMonetary incentive delay taskReward processingLoss processingPresent functional magnetic resonance imaging (fMRI) studyControl comparison groupIncentive delay taskVentral striatal activationPG groupMonetary rewardsVentromedial prefrontal cortexSimilar associationImaging studiesFrontostriatal activityLoss anticipationConsistent alterationsActivation changesPrefrontal cortexLevels of impulsivityMemantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism
Jamadar S, DeVito EE, Jiantonio RE, Meda SA, Stevens MC, Potenza MN, Krystal JH, Pearlson GD. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology 2012, 222: 129-140. PMID: 22311382, PMCID: PMC3674025, DOI: 10.1007/s00213-011-2628-2.Peer-Reviewed Original ResearchConceptsNMDA receptor antagonistFamily historyFHN subjectsReceptor antagonistFHP subjectsN-methyl-D-aspartate receptor functionReceptor functionIdentical-appearing placeboEffects of memantineFMRI activityNMDA receptor functionCorrect rejectsSingle doseMemantineGo/No-Go taskSeparate daysTemporal regionsCingulate activation
2010
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors. Biological Psychiatry 2010, 69: 675-683. PMID: 21126735, PMCID: PMC3677031, DOI: 10.1016/j.biopsych.2010.09.049.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskNAcc activationReward anticipationDelay taskFamily history-positive individualsAbnormal reward processingRegional brain activationNucleus accumbens activationFunctional magnetic resonanceReward system activitySubstance-abusing individualsReward prospectReward sensitivityNeural correlatesImpulsivity constructsSubstance abuse historyImpulsivity factorsReward processingBehavioral impulsivityAtypical activationBrain activationOutcome phaseBiological predispositionTask phasesBehavioral and Biological Indicators of Impulsivity in the Development of Alcohol Use, Problems, and Disorders
Lejuez CW, Magidson JF, Mitchell SH, Sinha R, Stevens MC, De Wit H. Behavioral and Biological Indicators of Impulsivity in the Development of Alcohol Use, Problems, and Disorders. Alcohol Clinical And Experimental Research 2010, 34: 1334-1345. PMID: 20491733, PMCID: PMC3182265, DOI: 10.1111/j.1530-0277.2010.01217.x.Peer-Reviewed Original Research
2009
Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis
Meda SA, Stevens MC, Potenza MN, Pittman B, Gueorguieva R, Andrews MM, Thomas AD, Muska C, Hylton JL, Pearlson GD. Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis. Behavioural Pharmacology 2009, 20: 390-399. PMID: 19724194, PMCID: PMC3268653, DOI: 10.1097/fbp.0b013e32833113a3.Peer-Reviewed Original ResearchConceptsSelf-report measuresImpulsivity domainsImpulsivity constructsSelf-reported impulsivityDistinct neural systemsAspects of impulsivitySelf-report constructsSelf-reported compulsivityMeasures of impulsivityReward/punishmentConstruct of impulsivitySupplementary goalCurrent cocaine usersTemporal discountingFive-factor solutionLaboratory tasksMaladaptive behaviorsDifferent domainsImpulsivityMultidimensional constructBehavioral activationNeural systemsHuman behaviorBehavioral studiesSupplemental analyses