2024
Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group
Gao Y, Staginnus M, Group E, Gao Y, Staginnus M, Townend S, Arango C, Bajaj S, Banaschewski T, Barker E, Benegal V, Berluti K, Bernhard A, Blair R, Boateng C, Bokde A, Brandeis D, Buitelaar J, Burt S, Cardinale E, Castro-Fornieles J, Chen H, Chen X, Chester S, Colins O, Cornwell H, Craig M, Cubillo A, Desrivieres S, Díaz D, Dietrich A, Dong D, Dykstra A, Franke B, Freitag C, Glennon J, Gonzalez-Madruga K, Hagan C, Hoekstra P, Holla B, Hyde L, Ibrahim K, Jabeen N, Jackson R, Jiang Y, Kohls G, Konrad K, Kypta-Vivanco A, Lamers K, Ma R, Marsh A, Martinelli A, Martinot J, Michalska K, Ming Q, Minosse S, Mitchell C, Monk C, Murphy D, Mycue L, Naaijen J, Oosterling M, Passamonti L, Pauli R, Alonso M, Phillips H, Ploe M, Raschle N, Roberts R, Rogers J, Rosa-Justicia M, Sagar-Ouriaghli I, Schulze U, Schumann G, Sethi A, Smaragdi A, Sonuga-Barke E, Stadler C, Stevens M, Sukhodolsky D, Sully K, Sun X, Toschi N, Townsend C, van der Wee N, Vermeiren R, Viding E, Wang X, Westerman H, Wu Q, Yao S, Zhang J, Zhou J, Zhou J, Jahanshad N, Thomopoulos S, Ching C, Kang M, Thompson P, Klapwijk E, Pine D, Baskin-Sommers A, Cecil C, Aghajani M, Walton E, Fairchild G, De Brito S. Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group. The Lancet Psychiatry 2024, 11: 620-632. PMID: 39025633, DOI: 10.1016/s2215-0366(24)00187-1.Peer-Reviewed Original ResearchConceptsGroup-by-age interactionCallous-unemotional traitsConduct disorder groupConduct disorderBrain structural alterationsSubcortical volumesDisorder groupDiagnosis of conduct disorderCaudal anterior cingulate cortexAnalysis of structural MRI dataCortical thicknessT1-weighted MRI brain scansBrain structural correlatesAnterior cingulate cortexSuperior temporal sulcusStructural MRI dataAssess group differencesMRI brain scansNucleus accumbensADHD comorbidityCingulate cortexDisorder subtypesSmaller amygdalaBrain alterationsTemporal sulcus
2023
Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associationsChanges in Neural Activity Following a Randomized Trial of Cognitive Behavioral Therapy for Hoarding Disorder
Tolin D, Levy H, Hallion L, Wootton B, Jaccard J, Diefenbach G, Stevens M. Changes in Neural Activity Following a Randomized Trial of Cognitive Behavioral Therapy for Hoarding Disorder. Journal Of Consulting And Clinical Psychology 2023, 91: 242-250. PMID: 36877480, PMCID: PMC10175200, DOI: 10.1037/ccp0000804.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyMedial intraparietal areaDorsal anterior cingulate cortexIntraparietal areaHD patientsRostral cingulateDorsolateral prefrontalBehavioral therapyVentral insular cortexDACC activationAnterior intraparietal areaNeural activityGroup cognitive behavioral therapyAnterior cingulate cortexRight dorsolateral prefrontalFunctional magnetic resonance imagingMagnetic resonance imagingCaudal cingulateClinical trialsInsular cortexRight amygdalaTherapeutic benefitSymptom reductionCingulate cortexResonance imaging
2022
Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Ivanov I, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Balachander S, Baker JT, Banaj N, Bargalló N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Diniz JB, Ely BA, Feusner JD, Ferreira S, Fitzgerald KD, Fontaine M, Gruner P, Hanna GL, Hirano Y, Hoexter MQ, Huyser C, Ikari K, James A, Jaspers-Fayer F, Jiang H, Kathmann N, Kaufmann C, Kim M, Koch K, Kwon JS, Lázaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, Oh S, Perriello C, Piacentini JC, Picó-Pérez M, Piras F, Piras F, Reddy YCJ, Manrique DR, Sakai Y, Shimizu E, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, van Rooij D, Veltman DJ, van der Werf YD, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zarei M, Zhang F, Zhao Q, Jahanshad N, Thomopoulos SI, Thompson PM, Stein DJ, van den Heuvel OA, O'Neill J, Group T, Poletti S, Fridgeirsson E, Ikuta T, de Wit S, Vriend C, Kasprzak S, Kuno M, Takahashi J, Miguel E, Shavitt R, Hough M, Pariente J, Ortiz A, Bertolín S, Real E, Segalàs C, Moreira P, Sousa N, Narumoto J, Yamada K, Tang J, Fouche J, Kim T, Choi S, Ha M, Park S. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium. Journal Of Affective Disorders 2022, 318: 204-216. PMID: 36041582, DOI: 10.1016/j.jad.2022.08.084.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderUnmedicated patientsOlder adultsAssociation of medicationVolumes of putamenSubcortical brain structuresReuptake inhibitorsVentricular hypertrophyHippocampal atrophyMedicated patientsPsychotropic medicationsTherapeutic responseHippocampal volumeStriatal volumeSubcortical nucleiPatientsPsychotic disordersAntipsychoticsSubcortical morphologyStructural MRINormal agingBrain structuresBenzodiazepinesOCD patientsENIGMA consortiumStructural language impairment in Autism Spectrum Disorder versus Loss of Autism Diagnosis: Behavioral and neural characteristics
Larson C, Rivera-Figueroa K, Thomas H, Fein D, Stevens M, Eigsti I. Structural language impairment in Autism Spectrum Disorder versus Loss of Autism Diagnosis: Behavioral and neural characteristics. NeuroImage Clinical 2022, 34: 103043. PMID: 35567947, PMCID: PMC9112023, DOI: 10.1016/j.nicl.2022.103043.Peer-Reviewed Original ResearchConceptsStructural language impairmentAutism spectrum disorderLanguage impairmentSpectrum disorderAutism diagnosisLanguage-related brain regionsStructural language abilitiesStructural language difficultiesLeft hemisphere lateralizationFunctional MRI resultsFunctional neuroimaging methodsRecalling SentencesHemisphere lateralizationLanguage abilityNeural specializationADHD symptomsSocial abilitiesASD symptomsLanguage difficultiesLanguage functionNeural characteristicsNeuroimaging methodsGroup differencesBrain regionsOmnibus measureThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volume
2021
Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
Li T, van Rooij D, Mota N, Buitelaar J, Ambrosino S, Banaschewski T, Bandeira C, Bau C, Baumeister S, Baur‐Streubel R, Bellgrove M, Biederman J, Bralten J, Bramati I, Brandeis D, Berm S, Busatto G, Calvo A, Castellanos F, Cercignani M, Chantiluke K, Christakou A, Coghill D, Conzelmann A, Cubillo A, Cupertino R, de Zeeuw P, Durston S, Earl E, Epstein J, Ethofer T, Fallgatter A, Fair D, Faraone S, Frodl T, Gabel M, Gogberashvili T, Grevet E, Haavik J, Harrison N, Hartman C, Heslenfeld D, Hoekstra P, Høvik M, Jahanshad N, Kardatzki B, Karkashadze G, Kelly C, Kohls G, Konrad K, Kuntsi J, Lazaro L, Lera‐Miguel S, Lesch K, Louza M, Lundervold A, Malpas C, Mattos P, McCarthy H, Nicolau R, Nigg J, Tuura R, Oosterlaan J, Oranje B, Paloyelis Y, Pauli P, Picon F, Plessen K, Ramos‐Quiroga J, Reif A, Reneman L, Rosa P, Rubia K, Schrantee A, Schweren L, Seitz J, Shaw P, Silk T, Skokauskas N, Vila J, Soloveva A, Stevens M, Sudre G, Tamm L, Thompson P, Tovar‐Moll F, van Erp T, Vance A, Vilarroya O, Vives‐Gilabert Y, von Polier G, Walitza S, Yoncheva Y, Zanetti M, Ziegler G, Anikin A, Asherson P, Baranov A, Chaim‐Avanicini T, Dale A, Doyle A, Jernigan T, Hohmann S, Kapilushniy D, Mehta M, Namazova‐Baranova L, Novotny S, Weiss E, Schwarz L, Hoogman M, Vasquez A, Franke B. Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes. Journal Of Child Psychology And Psychiatry 2021, 62: 1140-1149. PMID: 33786843, PMCID: PMC8403135, DOI: 10.1111/jcpp.13384.Peer-Reviewed Original Research
2020
Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups
Boedhoe PSW, van Rooij D, Hoogman M, Twisk JWR, Schmaal L, Abe Y, Alonso P, Ameis SH, Anikin A, Anticevic A, Arango C, Arnold PD, Asherson P, Assogna F, Auzias G, Banaschewski T, Baranov A, Batistuzzo MC, Baumeister S, Baur-Streubel R, Behrmann M, Bellgrove MA, Benedetti F, Beucke JC, Biederman J, Bollettini I, Bose A, Bralten J, Bramati IE, Brandeis D, Brem S, Brennan BP, Busatto GF, Calderoni S, Calvo A, Calvo R, Castellanos FX, Cercignani M, Chaim-Avancini TM, Chantiluke KC, Cheng Y, Cho KIK, Christakou A, Coghill D, Conzelmann A, Cubillo AI, Dale AM, Dallaspezia S, Daly E, Denys D, Deruelle C, Di Martino A, Dinstein I, Doyle AE, Durston S, Earl EA, Ecker C, Ehrlich S, Ely BA, Epstein JN, Ethofer T, Fair DA, Fallgatter AJ, Faraone SV, Fedor J, Feng X, Feusner JD, Fitzgerald J, Fitzgerald KD, Fouche JP, Freitag CM, Fridgeirsson EA, Frodl T, Gabel MC, Gallagher L, Gogberashvili T, Gori I, Gruner P, Gürsel DA, Haar S, Haavik J, Hall GB, Harrison NA, Hartman CA, Heslenfeld DJ, Hirano Y, Hoekstra PJ, Hoexter MQ, Hohmann S, Høvik MF, Hu H, Huyser C, Jahanshad N, Jalbrzikowski M, James A, Janssen J, Jaspers-Fayer F, Jernigan TL, Kapilushniy D, Kardatzki B, Karkashadze G, Kathmann N, Kaufmann C, Kelly C, Khadka S, King JA, Koch K, Kohls G, Konrad K, Kuno M, Kuntsi J, Kvale G, Kwon JS, Lázaro L, Lera-Miguel S, Lesch KP, Hoekstra L, Liu Y, Lochner C, Louza MR, Luna B, Lundervold AJ, Malpas CB, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Mattos P, McCarthy H, McGrath J, Mehta MA, Menchón JM, Mennes M, Martinho MM, Moreira PS, Morer A, Morgado P, Muratori F, Murphy CM, Murphy DGM, Nakagawa A, Nakamae T, Nakao T, Namazova-Baranova L, Narayanaswamy JC, Nicolau R, Nigg JT, Novotny SE, Nurmi EL, Weiss EO, O'Gorman Tuura RL, O'Hearn K, O'Neill J, Oosterlaan J, Oranje B, Paloyelis Y, Parellada M, Pauli P, Perriello C, Piacentini J, Piras F, Piras F, Plessen KJ, Puig O, Ramos-Quiroga JA, Reddy YCJ, Reif A, Reneman L, Retico A, Rosa PGP, Rubia K, Rus OG, Sakai Y, Schrantee A, Schwarz L, Schweren LJS, Seitz J, Shaw P, Shook D, Silk TJ, Simpson HB, Skokauskas N, Soliva Vila JC, Solovieva A, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Sudre G, Szeszko PR, Tamm L, Taylor MJ, Tolin DF, Tosetti M, Tovar-Moll F, Tsuchiyagaito A, van Erp TGM, van Wingen GA, Vance A, Venkatasubramanian G, Vilarroya O, Vives-Gilabert Y, von Polier GG, Walitza S, Wallace GL, Wang Z, Wolfers T, Yoncheva YN, Yun JY, Zanetti MV, Zhou F, Ziegler GC, Zierhut KC, Zwiers MP, Thompson P, Stein D, Buitelaar J, Franke B, van den Heuvel O. Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups. American Journal Of Psychiatry 2020, 177: 834-843. PMID: 32539527, PMCID: PMC8296070, DOI: 10.1176/appi.ajp.2020.19030331.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAutism spectrum disorderObsessive-compulsive disorderDeficit hyperactivity disorderFrontal cortexCommon neurodevelopmental disorderStandardized processing protocolsStructural brain differencesCortical thickness differencesWhole-brain MRI dataCortical thicknessHyperactivity disorderCortical surface areaSpectrum disorderBrain differencesSmaller hippocampal volumesDifferent age groupsRegional cortical thicknessSubcortical brain volumesClinical groupsStructural brainSmaller intracranial volumeShared differenceNeurodevelopmental disordersHippocampal differences
2019
Efficacy and Mediators of a Group Cognitive–Behavioral Therapy for Hoarding Disorder: A Randomized Trial
Tolin DF, Wootton BM, Levy HC, Hallion LS, Worden BL, Diefenbach GJ, Jaccard J, Stevens MC. Efficacy and Mediators of a Group Cognitive–Behavioral Therapy for Hoarding Disorder: A Randomized Trial. Journal Of Consulting And Clinical Psychology 2019, 87: 590-602. PMID: 31008633, DOI: 10.1037/ccp0000405.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapyCognitive behavioral therapyBrief group cognitive-behavioural therapyEmotional distress toleranceProblem-solving trainingMotivational interviewing strategiesSubjective cognitive impairmentMaladaptive beliefsDistress tolerancePsychological treatmentHoarding DisorderHypothesized mediatorsTreatment outcomesSession practiceContingency managementCognitive impairmentSymptoms of HDGroup sessionsIndependent evaluatorsPsychiatric disordersTreatment conditionsWait listAdultsAdditional researchDisordersBrain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples
Hoogman M, Muetzel R, Guimaraes J, Shumskaya E, Mennes M, Zwiers M, Jahanshad N, Sudre G, Wolfers T, Earl E, Soliva Vila J, Vives-Gilabert Y, Khadka S, Novotny S, Hartman C, Heslenfeld D, Schweren L, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini T, Rosa P, Zanetti M, Malpas C, Kohls G, von Polier G, Seitz J, Biederman J, Doyle A, Dale A, van Erp T, Epstein J, Jernigan T, Baur-Streubel R, Ziegler G, Zierhut K, Schrantee A, Høvik M, Lundervold A, Kelly C, McCarthy H, Skokauskas N, O’Gorman Tuura R, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke K, Christakou A, Vance A, Cercignani M, Gabel M, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati I, Tovar-Moll F, Fallgatter A, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen K, Kuntsi J, Mehta M, Paloyelis Y, Harrison N, Bellgrove M, Silk T, Cubillo A, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos F, Yoncheva Y, Haavik J, Reneman L, Conzelmann A, Lesch K, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Busatto G, Louza M, Durston S, Hoekstra P, Oosterlaan J, Stevens M, Ramos-Quiroga J, Vilarroya O, Fair D, Nigg J, Thompson P, Buitelaar J, Faraone S, Shaw P, Tiemeier H, Bralten J, Franke B. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples. American Journal Of Psychiatry 2019, 176: 531-542. PMID: 31014101, PMCID: PMC6879185, DOI: 10.1176/appi.ajp.2019.18091033.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCortical measuresDeficit hyperactivity disorderChild Behavior ChecklistAdult groupAttention ScaleADHD symptomsAttention problemsCortical thicknessFusiform gyrusHyperactivity disorderADHD diagnosisCortical surface areaLifespan trajectoriesBehavior ChecklistFamilial effectsFuture longitudinal studiesTemporal regionsNeuroimage studiesBrain regionsLarge significant effectLow surface area valuesLongitudinal studyAdolescentsFrontal cortex
2018
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Kong XZ, Mathias SR, Guadalupe T, Glahn D, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher S, Thompson P, Francks C, Kong X, Mathias S, Guadalupe T, Abé C, Agartz I, Akudjedu T, Aleman A, Alhusaini S, Allen N, Ames D, Andreassen O, Vasquez A, Armstrong N, Bergo F, Bastin M, Batalla A, Bauer J, Baune B, Baur-Streubel R, Biederman J, Blaine S, Boedhoe P, Bøen E, Bose A, Bralten J, Brandeis D, Brem S, Brodaty H, Yüksel D, Brooks S, Buitelaar J, Bürger C, Bülow R, Calhoun V, Calvo A, Canales-Rodríguez E, Canive J, Cannon D, Caparelli E, Castellanos F, Cavalleri G, Cendes F, Chaim-Avancini T, Chantiluke K, Chen Q, Chen X, Cheng Y, Christakou A, Clark V, Coghill D, Connolly C, Conzelmann A, Córdova-Palomera A, Cousijn J, Crow T, Cubillo A, Dale A, Dannlowski U, Ambrosino de Bruttopilo S, de Zeeuw P, Deary I, Delanty N, Demeter D, Di Martino A, Dickie E, Dietsche B, Doan N, Doherty C, Doyle A, Durston S, Earl E, Ehrlich S, Ekman C, Elvsåshagen T, Epstein J, Fair D, Faraone S, Fernández G, Filho G, Förster K, Fouche J, Foxe J, Frodl T, Fuentes-Claramonte P, Fullerton J, Garavan H, Garcia D, Gotlib I, Goudriaan A, Grabe H, Groenewold N, Grotegerd D, Gruber O, Gurholt T, Haavik J, Hahn T, Hansell N, Harris M, Hartman C, Hernández M, Heslenfeld D, Hester R, Hibar D, Ho B, Ho T, Hoekstra P, van Holst R, Hoogman M, Høvik M, Howells F, Hugdahl K, Huyser C, Ingvar M, Irwin L, Ishikawa A, James A, Jahanshad N, Jernigan T, Jönsson E, Kähler C, Kaleda V, Kelly C, Kerich M, Keshavan M, Khadka S, Kircher T, Kohls G, Konrad K, Korucuoglu O, Krämer B, Krug A, Kwon J, Lambregts-Rommelse N, Landén M, Lázaro L, Lebedeva I, Lenroot R, Lesch K, Li Q, Lim K, Liu J, Lochner C, London E, Lonning V, Lorenzetti V, Luciano M, Luijten M, Lundervold A, Mackey S, MacMaster F, Maingault S, Malpas C, Malt U, Mataix-Cols D, Martin-Santos R, Mayer A, McCarthy H, Mitchell P, Mueller B, Maniega S, Mazoyer B, McDonald C, McLellan Q, McMahon K, McPhilemy G, Momenan R, Morales A, Narayanaswamy J, Moreira J, Nerland S, Nestor L, Newman E, Nigg J, Nordvik J, Novotny S, Weiss E, O’Gorman R, Oosterlaan J, Oranje B, Orr C, Overs B, Pauli P, Paulus M, Plessen K, von Polier G, Pomarol-Clotet E, Portella M, Qiu J, Radua J, Ramos-Quiroga J, Reddy Y, Reif A, Roberts G, Rosa P, Rubia K, Sacchet M, Sachdev P, Salvador R, Schmaal L, Schulte-Rüther M, Schweren L, Seidman L, Seitz J, Serpa M, Shaw P, Shumskaya E, Silk T, Simmons A, Simulionyte E, Sinha R, Sjoerds Z, Smelror R, Soliva J, Solowij N, Souza-Duran F, Sponheim S, Stein D, Stein E, Stevens M, Strike L, Sudre G, Sui J, Tamm L, Temmingh H, Thoma R, Tomyshev A, Tronchin G, Turner J, Uhlmann A, van Erp T, van den Heuvel O, van der Meer D, van Eijk L, Vance A, Veer I, Veltman D, Venkatasubramanian G, Vilarroya O, Vives-Gilabert Y, Voineskos A, Völzke H, Vuletic D, Walitza S, Walter H, Walton E, Wardlaw J, Wen W, Westlye L, Whelan C, White T, Wiers R, Wright M, Wittfeld K, Yang T, Yasuda C, Yoncheva Y, Yücel M, Yun J, Zanetti M, Zhen Z, Zhu X, Ziegler G, Zierhut K, de Zubicaray G, Zwiers M, Glahn D, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher S, Thompson P, Francks C, Farde L, Flyckt L, Engberg G, Erhardt S, Fatouros-Bergman H, Cervenka S, Schwieler L, Piehl F, Agartz I, Collste K, Victorsson P, Malmqvist A, Hedberg M, Orhan F. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e5154-e5163. PMID: 29764998, PMCID: PMC5984496, DOI: 10.1073/pnas.1718418115.Peer-Reviewed Original ResearchConceptsBrain asymmetryCortical thicknessHealthy individualsAltered brain asymmetryCerebral cortical asymmetryENIGMA consortiumTransverse temporal gyrusPopulation-level asymmetriesInferior frontal gyrusPsychiatric disordersMRI scansParahippocampal gyrusCardinal featuresSignificant associationIntracranial volumeNeuropsychiatric disordersTemporal gyrusThicker cortexFrontal gyrusCortical asymmetryHuman brain organizationLeft hemisphereGyrusLateralized functionsBrain organization
2017
Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study
Vaarwerk B, van der Lee J, Breunis W, Orbach D, Chisholm J, Cozic N, Jenney M, van Rijn R, McHugh K, Gallego S, Glosli H, Devalck C, Gaze M, Kelsey A, Bergeron C, Stevens M, Oberlin O, Minard‐Colin V, Merks J. Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study. Cancer 2017, 124: 1016-1024. PMID: 29211298, DOI: 10.1002/cncr.31157.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapyChildChild, PreschoolDisease-Free SurvivalFemaleHumansInduction ChemotherapyInfantInternational CooperationMaleMedical OncologyMesenchymomaOutcome Assessment, Health CarePediatricsRetrospective StudiesRhabdomyosarcomaSocieties, MedicalConceptsFailure-free survivalCourses of chemotherapyOverall survivalRadiologic responseProgressive diseasePrognostic valueCox proportional hazards regression analysisEarly responseProportional hazards regression analysisAdjusted hazard ratioKaplan-Meier methodCR/PRHazards regression analysisEfficacy of chemotherapyCox proportional hazardsCurrent European guidelinesInduction chemotherapyOS ratesHazard ratioPrognostic impactPediatric patientsIII patientsChemotherapyResponse assessmentPatientsAltered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge
Zempsky W, Stevens M, Santanelli J, Gaynor A, Khadka S. Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge. The Clinical Journal Of Pain 2017, 33: 1060-1070. PMID: 28272117, DOI: 10.1097/ajp.0000000000000492.Peer-Reviewed Original ResearchConceptsSickle cell diseaseChronic pain disordersPain challengePain disordersCell diseaseSomatosensory networkBrain regionsAltered functional connectivityFunctional connectivity abnormalitiesSubcortical brain regionsLower functional integrationDefault mode networkCentral sensitizationRed blood cellsNociceptive informationPain sensitizationChronic painPain responseParietal lobe regionsPressure algometerPainful stimuliNeurodevelopmental abnormalitiesSCD controlsConnectivity abnormalitiesSalience networkDecisional Informatics for Psychosocial Rehabilitation
Choi J, Lysaker PH, Bell MD, Dixon L, Margolies P, Gold M, Golden-Roose E, Thime W, Haber LC, Dewberry MJ, Stevens M, Pearlson GD, Fiszdon JM. Decisional Informatics for Psychosocial Rehabilitation. The Journal Of Nervous And Mental Disease 2017, 205: 867-872. PMID: 28991149, PMCID: PMC5827965, DOI: 10.1097/nmd.0000000000000747.Peer-Reviewed Original ResearchConceptsTraditional treatment planningOutpatient rehabilitation treatmentLarge effect sizesMental flexibilityGeneral education diplomaBehavioral therapyProcessing speedPsychosocial rehabilitationHigh agencyGroup differencesComputerized clinical decision support toolClinical decision support toolSevere mental illnessTreatment planningPsychiatric rehabilitationFeasibility pilotComparison groupEffect sizeSocial functionBaseline symptomsComputerized decision support systemMental illnessTreatment decisionsPatient needsRehabilitation treatmentPupillometer-Based Neurofeedback Cognitive Training to Improve Processing Speed and Social Functioning in Individuals at Clinical High Risk for Psychosis
Choi J, Corcoran CM, Fiszdon JM, Stevens M, Javitt DC, Deasy M, Haber LC, Dewberry MJ, Pearlson GD. Pupillometer-Based Neurofeedback Cognitive Training to Improve Processing Speed and Social Functioning in Individuals at Clinical High Risk for Psychosis. Psychiatric Rehabilitation Journal 2017, 40: 33-42. PMID: 27560455, PMCID: PMC5326611, DOI: 10.1037/prj0000217.Peer-Reviewed Original ResearchConceptsProcessing speed trainingClinical high riskOverall social adjustmentProcessing speedSocial adjustmentInformation processing dysfunctionVisual scanning efficiencyTablet-based programCognitive trainingSocial avoidanceProcessing dysfunctionPS deficitsSocial situationsCHR participantsPST groupInformation processingPost trainingSocial behaviorTraining formatSpeed trainingSocial functionBehavioral deficitsRole functioningSocial morbidityEntire sample
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatientsNeurofunctional Reward Processing Changes in Cocaine Dependence During Recovery
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Carroll KM, Potenza MN. Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 2016, 41: 2112-2121. PMID: 26792441, PMCID: PMC4908642, DOI: 10.1038/npp.2016.11.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus activityCD participantsNegative urine screensReward/loss processingHealthy control participantsReward processingMeaningful outcome indicatorsDopamine-innervated regionsFunctional magnetic resonanceInferior frontal gyrus activityCD outpatientsTest-retest resultsPrefrontal cortex activityVentromedial prefrontal cortex activityUrine screensNeurofunctional alterationsVentral striatal activityCD groupNeurofunctional changesLong-term recoveryDrug useNeurobiological changesCocaine abstinenceCocaine dependenceStriatal activity
2015
Restricted and Repetitive Behaviors as Predictors of Outcome in Autism Spectrum Disorders
Troyb E, Knoch K, Herlihy L, Stevens MC, Chen CM, Barton M, Treadwell K, Fein D. Restricted and Repetitive Behaviors as Predictors of Outcome in Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2015, 46: 1282-1296. PMID: 26676629, PMCID: PMC8054273, DOI: 10.1007/s10803-015-2668-2.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderRepetitive behaviorsGreater ASD symptom severityAge 8ASD symptom severityParts of objectsASD symptomatologyCognitive functioningAdaptive skillsSensory interestsStereotyped motor movementsPreschool yearsMotor movementsLate childhoodSymptom severityAdaptive abilityRRBsChildrenPredictors of outcomeOutcome of childrenDisordersFunctioningSkillsSymptomatologyLanguage comprehension and brain function in individuals with an optimal outcome from autism
Eigsti IM, Stevens MC, Schultz RT, Barton M, Kelley E, Naigles L, Orinstein A, Troyb E, Fein DA. Language comprehension and brain function in individuals with an optimal outcome from autism. NeuroImage Clinical 2015, 10: 182-191. PMID: 26862477, PMCID: PMC4707189, DOI: 10.1016/j.nicl.2015.11.014.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderTypical developmentTD groupBrain networksSentence comprehension taskIndividuals ages 8Functional MRI scansLanguage comprehensionASD groupComprehension taskLanguage abilityLateralized regionsLanguage performanceRight homologueOO individualsSpectrum disorderBrain functioningPosterior cingulateLanguage processingAge 8Temporal regionsBrain regionsBrain functionMinority of individualsIntensive learningA Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers
Worhunsky PD, Dager AD, Meda SA, Khadka S, Stevens MC, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Potenza MN, Pearlson GD. A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers. Neuropsychopharmacology 2015, 41: 1637-1647. PMID: 26514582, PMCID: PMC4832027, DOI: 10.1038/npp.2015.332.Peer-Reviewed Original ResearchConceptsAlcohol useYoung adult drinkersYoung adultsPreliminary prospective studyAdult drinkersExcessive alcohol useAlcohol use disorderFunctional network activityProspective studyUse disordersFunctional brain networksGo/No-Go taskNeurobiological alterationsDomain scoresGreater riskDaily drinksAddictive disordersDrinkersDrinking occasionsLongitudinal studyFronto-parietal circuitryBrain networks