2024
Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group
Gao Y, Staginnus M, Group E, Gao Y, Staginnus M, Townend S, Arango C, Bajaj S, Banaschewski T, Barker E, Benegal V, Berluti K, Bernhard A, Blair R, Boateng C, Bokde A, Brandeis D, Buitelaar J, Burt S, Cardinale E, Castro-Fornieles J, Chen H, Chen X, Chester S, Colins O, Cornwell H, Craig M, Cubillo A, Desrivieres S, Díaz D, Dietrich A, Dong D, Dykstra A, Franke B, Freitag C, Glennon J, Gonzalez-Madruga K, Hagan C, Hoekstra P, Holla B, Hyde L, Ibrahim K, Jabeen N, Jackson R, Jiang Y, Kohls G, Konrad K, Kypta-Vivanco A, Lamers K, Ma R, Marsh A, Martinelli A, Martinot J, Michalska K, Ming Q, Minosse S, Mitchell C, Monk C, Murphy D, Mycue L, Naaijen J, Oosterling M, Passamonti L, Pauli R, Alonso M, Phillips H, Ploe M, Raschle N, Roberts R, Rogers J, Rosa-Justicia M, Sagar-Ouriaghli I, Schulze U, Schumann G, Sethi A, Smaragdi A, Sonuga-Barke E, Stadler C, Stevens M, Sukhodolsky D, Sully K, Sun X, Toschi N, Townsend C, van der Wee N, Vermeiren R, Viding E, Wang X, Westerman H, Wu Q, Yao S, Zhang J, Zhou J, Zhou J, Jahanshad N, Thomopoulos S, Ching C, Kang M, Thompson P, Klapwijk E, Pine D, Baskin-Sommers A, Cecil C, Aghajani M, Walton E, Fairchild G, De Brito S. Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group. The Lancet Psychiatry 2024, 11: 620-632. PMID: 39025633, DOI: 10.1016/s2215-0366(24)00187-1.Peer-Reviewed Original ResearchConceptsGroup-by-age interactionCallous-unemotional traitsConduct disorder groupConduct disorderBrain structural alterationsSubcortical volumesDisorder groupDiagnosis of conduct disorderCaudal anterior cingulate cortexAnalysis of structural MRI dataCortical thicknessT1-weighted MRI brain scansBrain structural correlatesAnterior cingulate cortexSuperior temporal sulcusStructural MRI dataAssess group differencesMRI brain scansNucleus accumbensADHD comorbidityCingulate cortexDisorder subtypesSmaller amygdalaBrain alterationsTemporal sulcus
2022
Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Ivanov I, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Balachander S, Baker JT, Banaj N, Bargalló N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Diniz JB, Ely BA, Feusner JD, Ferreira S, Fitzgerald KD, Fontaine M, Gruner P, Hanna GL, Hirano Y, Hoexter MQ, Huyser C, Ikari K, James A, Jaspers-Fayer F, Jiang H, Kathmann N, Kaufmann C, Kim M, Koch K, Kwon JS, Lázaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, Oh S, Perriello C, Piacentini JC, Picó-Pérez M, Piras F, Piras F, Reddy YCJ, Manrique DR, Sakai Y, Shimizu E, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, van Rooij D, Veltman DJ, van der Werf YD, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zarei M, Zhang F, Zhao Q, Jahanshad N, Thomopoulos SI, Thompson PM, Stein DJ, van den Heuvel OA, O'Neill J, Group T, Poletti S, Fridgeirsson E, Ikuta T, de Wit S, Vriend C, Kasprzak S, Kuno M, Takahashi J, Miguel E, Shavitt R, Hough M, Pariente J, Ortiz A, Bertolín S, Real E, Segalàs C, Moreira P, Sousa N, Narumoto J, Yamada K, Tang J, Fouche J, Kim T, Choi S, Ha M, Park S. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium. Journal Of Affective Disorders 2022, 318: 204-216. PMID: 36041582, DOI: 10.1016/j.jad.2022.08.084.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderUnmedicated patientsOlder adultsAssociation of medicationVolumes of putamenSubcortical brain structuresReuptake inhibitorsVentricular hypertrophyHippocampal atrophyMedicated patientsPsychotropic medicationsTherapeutic responseHippocampal volumeStriatal volumeSubcortical nucleiPatientsPsychotic disordersAntipsychoticsSubcortical morphologyStructural MRINormal agingBrain structuresBenzodiazepinesOCD patientsENIGMA consortiumThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volume
2020
Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups
Boedhoe PSW, van Rooij D, Hoogman M, Twisk JWR, Schmaal L, Abe Y, Alonso P, Ameis SH, Anikin A, Anticevic A, Arango C, Arnold PD, Asherson P, Assogna F, Auzias G, Banaschewski T, Baranov A, Batistuzzo MC, Baumeister S, Baur-Streubel R, Behrmann M, Bellgrove MA, Benedetti F, Beucke JC, Biederman J, Bollettini I, Bose A, Bralten J, Bramati IE, Brandeis D, Brem S, Brennan BP, Busatto GF, Calderoni S, Calvo A, Calvo R, Castellanos FX, Cercignani M, Chaim-Avancini TM, Chantiluke KC, Cheng Y, Cho KIK, Christakou A, Coghill D, Conzelmann A, Cubillo AI, Dale AM, Dallaspezia S, Daly E, Denys D, Deruelle C, Di Martino A, Dinstein I, Doyle AE, Durston S, Earl EA, Ecker C, Ehrlich S, Ely BA, Epstein JN, Ethofer T, Fair DA, Fallgatter AJ, Faraone SV, Fedor J, Feng X, Feusner JD, Fitzgerald J, Fitzgerald KD, Fouche JP, Freitag CM, Fridgeirsson EA, Frodl T, Gabel MC, Gallagher L, Gogberashvili T, Gori I, Gruner P, Gürsel DA, Haar S, Haavik J, Hall GB, Harrison NA, Hartman CA, Heslenfeld DJ, Hirano Y, Hoekstra PJ, Hoexter MQ, Hohmann S, Høvik MF, Hu H, Huyser C, Jahanshad N, Jalbrzikowski M, James A, Janssen J, Jaspers-Fayer F, Jernigan TL, Kapilushniy D, Kardatzki B, Karkashadze G, Kathmann N, Kaufmann C, Kelly C, Khadka S, King JA, Koch K, Kohls G, Konrad K, Kuno M, Kuntsi J, Kvale G, Kwon JS, Lázaro L, Lera-Miguel S, Lesch KP, Hoekstra L, Liu Y, Lochner C, Louza MR, Luna B, Lundervold AJ, Malpas CB, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Mattos P, McCarthy H, McGrath J, Mehta MA, Menchón JM, Mennes M, Martinho MM, Moreira PS, Morer A, Morgado P, Muratori F, Murphy CM, Murphy DGM, Nakagawa A, Nakamae T, Nakao T, Namazova-Baranova L, Narayanaswamy JC, Nicolau R, Nigg JT, Novotny SE, Nurmi EL, Weiss EO, O'Gorman Tuura RL, O'Hearn K, O'Neill J, Oosterlaan J, Oranje B, Paloyelis Y, Parellada M, Pauli P, Perriello C, Piacentini J, Piras F, Piras F, Plessen KJ, Puig O, Ramos-Quiroga JA, Reddy YCJ, Reif A, Reneman L, Retico A, Rosa PGP, Rubia K, Rus OG, Sakai Y, Schrantee A, Schwarz L, Schweren LJS, Seitz J, Shaw P, Shook D, Silk TJ, Simpson HB, Skokauskas N, Soliva Vila JC, Solovieva A, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Sudre G, Szeszko PR, Tamm L, Taylor MJ, Tolin DF, Tosetti M, Tovar-Moll F, Tsuchiyagaito A, van Erp TGM, van Wingen GA, Vance A, Venkatasubramanian G, Vilarroya O, Vives-Gilabert Y, von Polier GG, Walitza S, Wallace GL, Wang Z, Wolfers T, Yoncheva YN, Yun JY, Zanetti MV, Zhou F, Ziegler GC, Zierhut KC, Zwiers MP, Thompson P, Stein D, Buitelaar J, Franke B, van den Heuvel O. Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups. American Journal Of Psychiatry 2020, 177: 834-843. PMID: 32539527, PMCID: PMC8296070, DOI: 10.1176/appi.ajp.2020.19030331.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAutism spectrum disorderObsessive-compulsive disorderDeficit hyperactivity disorderFrontal cortexCommon neurodevelopmental disorderStandardized processing protocolsStructural brain differencesCortical thickness differencesWhole-brain MRI dataCortical thicknessHyperactivity disorderCortical surface areaSpectrum disorderBrain differencesSmaller hippocampal volumesDifferent age groupsRegional cortical thicknessSubcortical brain volumesClinical groupsStructural brainSmaller intracranial volumeShared differenceNeurodevelopmental disordersHippocampal differences
2019
Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples
Hoogman M, Muetzel R, Guimaraes J, Shumskaya E, Mennes M, Zwiers M, Jahanshad N, Sudre G, Wolfers T, Earl E, Soliva Vila J, Vives-Gilabert Y, Khadka S, Novotny S, Hartman C, Heslenfeld D, Schweren L, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini T, Rosa P, Zanetti M, Malpas C, Kohls G, von Polier G, Seitz J, Biederman J, Doyle A, Dale A, van Erp T, Epstein J, Jernigan T, Baur-Streubel R, Ziegler G, Zierhut K, Schrantee A, Høvik M, Lundervold A, Kelly C, McCarthy H, Skokauskas N, O’Gorman Tuura R, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke K, Christakou A, Vance A, Cercignani M, Gabel M, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati I, Tovar-Moll F, Fallgatter A, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen K, Kuntsi J, Mehta M, Paloyelis Y, Harrison N, Bellgrove M, Silk T, Cubillo A, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos F, Yoncheva Y, Haavik J, Reneman L, Conzelmann A, Lesch K, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Busatto G, Louza M, Durston S, Hoekstra P, Oosterlaan J, Stevens M, Ramos-Quiroga J, Vilarroya O, Fair D, Nigg J, Thompson P, Buitelaar J, Faraone S, Shaw P, Tiemeier H, Bralten J, Franke B. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples. American Journal Of Psychiatry 2019, 176: 531-542. PMID: 31014101, PMCID: PMC6879185, DOI: 10.1176/appi.ajp.2019.18091033.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCortical measuresDeficit hyperactivity disorderChild Behavior ChecklistAdult groupAttention ScaleADHD symptomsAttention problemsCortical thicknessFusiform gyrusHyperactivity disorderADHD diagnosisCortical surface areaLifespan trajectoriesBehavior ChecklistFamilial effectsFuture longitudinal studiesTemporal regionsNeuroimage studiesBrain regionsLarge significant effectLow surface area valuesLongitudinal studyAdolescentsFrontal cortex
2018
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Kong XZ, Mathias SR, Guadalupe T, Glahn D, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher S, Thompson P, Francks C, Kong X, Mathias S, Guadalupe T, Abé C, Agartz I, Akudjedu T, Aleman A, Alhusaini S, Allen N, Ames D, Andreassen O, Vasquez A, Armstrong N, Bergo F, Bastin M, Batalla A, Bauer J, Baune B, Baur-Streubel R, Biederman J, Blaine S, Boedhoe P, Bøen E, Bose A, Bralten J, Brandeis D, Brem S, Brodaty H, Yüksel D, Brooks S, Buitelaar J, Bürger C, Bülow R, Calhoun V, Calvo A, Canales-Rodríguez E, Canive J, Cannon D, Caparelli E, Castellanos F, Cavalleri G, Cendes F, Chaim-Avancini T, Chantiluke K, Chen Q, Chen X, Cheng Y, Christakou A, Clark V, Coghill D, Connolly C, Conzelmann A, Córdova-Palomera A, Cousijn J, Crow T, Cubillo A, Dale A, Dannlowski U, Ambrosino de Bruttopilo S, de Zeeuw P, Deary I, Delanty N, Demeter D, Di Martino A, Dickie E, Dietsche B, Doan N, Doherty C, Doyle A, Durston S, Earl E, Ehrlich S, Ekman C, Elvsåshagen T, Epstein J, Fair D, Faraone S, Fernández G, Filho G, Förster K, Fouche J, Foxe J, Frodl T, Fuentes-Claramonte P, Fullerton J, Garavan H, Garcia D, Gotlib I, Goudriaan A, Grabe H, Groenewold N, Grotegerd D, Gruber O, Gurholt T, Haavik J, Hahn T, Hansell N, Harris M, Hartman C, Hernández M, Heslenfeld D, Hester R, Hibar D, Ho B, Ho T, Hoekstra P, van Holst R, Hoogman M, Høvik M, Howells F, Hugdahl K, Huyser C, Ingvar M, Irwin L, Ishikawa A, James A, Jahanshad N, Jernigan T, Jönsson E, Kähler C, Kaleda V, Kelly C, Kerich M, Keshavan M, Khadka S, Kircher T, Kohls G, Konrad K, Korucuoglu O, Krämer B, Krug A, Kwon J, Lambregts-Rommelse N, Landén M, Lázaro L, Lebedeva I, Lenroot R, Lesch K, Li Q, Lim K, Liu J, Lochner C, London E, Lonning V, Lorenzetti V, Luciano M, Luijten M, Lundervold A, Mackey S, MacMaster F, Maingault S, Malpas C, Malt U, Mataix-Cols D, Martin-Santos R, Mayer A, McCarthy H, Mitchell P, Mueller B, Maniega S, Mazoyer B, McDonald C, McLellan Q, McMahon K, McPhilemy G, Momenan R, Morales A, Narayanaswamy J, Moreira J, Nerland S, Nestor L, Newman E, Nigg J, Nordvik J, Novotny S, Weiss E, O’Gorman R, Oosterlaan J, Oranje B, Orr C, Overs B, Pauli P, Paulus M, Plessen K, von Polier G, Pomarol-Clotet E, Portella M, Qiu J, Radua J, Ramos-Quiroga J, Reddy Y, Reif A, Roberts G, Rosa P, Rubia K, Sacchet M, Sachdev P, Salvador R, Schmaal L, Schulte-Rüther M, Schweren L, Seidman L, Seitz J, Serpa M, Shaw P, Shumskaya E, Silk T, Simmons A, Simulionyte E, Sinha R, Sjoerds Z, Smelror R, Soliva J, Solowij N, Souza-Duran F, Sponheim S, Stein D, Stein E, Stevens M, Strike L, Sudre G, Sui J, Tamm L, Temmingh H, Thoma R, Tomyshev A, Tronchin G, Turner J, Uhlmann A, van Erp T, van den Heuvel O, van der Meer D, van Eijk L, Vance A, Veer I, Veltman D, Venkatasubramanian G, Vilarroya O, Vives-Gilabert Y, Voineskos A, Völzke H, Vuletic D, Walitza S, Walter H, Walton E, Wardlaw J, Wen W, Westlye L, Whelan C, White T, Wiers R, Wright M, Wittfeld K, Yang T, Yasuda C, Yoncheva Y, Yücel M, Yun J, Zanetti M, Zhen Z, Zhu X, Ziegler G, Zierhut K, de Zubicaray G, Zwiers M, Glahn D, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher S, Thompson P, Francks C, Farde L, Flyckt L, Engberg G, Erhardt S, Fatouros-Bergman H, Cervenka S, Schwieler L, Piehl F, Agartz I, Collste K, Victorsson P, Malmqvist A, Hedberg M, Orhan F. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e5154-e5163. PMID: 29764998, PMCID: PMC5984496, DOI: 10.1073/pnas.1718418115.Peer-Reviewed Original ResearchConceptsBrain asymmetryCortical thicknessHealthy individualsAltered brain asymmetryCerebral cortical asymmetryENIGMA consortiumTransverse temporal gyrusPopulation-level asymmetriesInferior frontal gyrusPsychiatric disordersMRI scansParahippocampal gyrusCardinal featuresSignificant associationIntracranial volumeNeuropsychiatric disordersTemporal gyrusThicker cortexFrontal gyrusCortical asymmetryHuman brain organizationLeft hemisphereGyrusLateralized functionsBrain organization
2017
Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study
Vaarwerk B, van der Lee J, Breunis W, Orbach D, Chisholm J, Cozic N, Jenney M, van Rijn R, McHugh K, Gallego S, Glosli H, Devalck C, Gaze M, Kelsey A, Bergeron C, Stevens M, Oberlin O, Minard‐Colin V, Merks J. Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study. Cancer 2017, 124: 1016-1024. PMID: 29211298, DOI: 10.1002/cncr.31157.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapyChildChild, PreschoolDisease-Free SurvivalFemaleHumansInduction ChemotherapyInfantInternational CooperationMaleMedical OncologyMesenchymomaOutcome Assessment, Health CarePediatricsRetrospective StudiesRhabdomyosarcomaSocieties, MedicalConceptsFailure-free survivalCourses of chemotherapyOverall survivalRadiologic responseProgressive diseasePrognostic valueCox proportional hazards regression analysisEarly responseProportional hazards regression analysisAdjusted hazard ratioKaplan-Meier methodCR/PRHazards regression analysisEfficacy of chemotherapyCox proportional hazardsCurrent European guidelinesInduction chemotherapyOS ratesHazard ratioPrognostic impactPediatric patientsIII patientsChemotherapyResponse assessmentPatients
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatients
2015
Restricted and Repetitive Behaviors as Predictors of Outcome in Autism Spectrum Disorders
Troyb E, Knoch K, Herlihy L, Stevens MC, Chen CM, Barton M, Treadwell K, Fein D. Restricted and Repetitive Behaviors as Predictors of Outcome in Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2015, 46: 1282-1296. PMID: 26676629, PMCID: PMC8054273, DOI: 10.1007/s10803-015-2668-2.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderRepetitive behaviorsGreater ASD symptom severityAge 8ASD symptom severityParts of objectsASD symptomatologyCognitive functioningAdaptive skillsSensory interestsStereotyped motor movementsPreschool yearsMotor movementsLate childhoodSymptom severityAdaptive abilityRRBsChildrenPredictors of outcomeOutcome of childrenDisordersFunctioningSkillsSymptomatologyLanguage comprehension and brain function in individuals with an optimal outcome from autism
Eigsti IM, Stevens MC, Schultz RT, Barton M, Kelley E, Naigles L, Orinstein A, Troyb E, Fein DA. Language comprehension and brain function in individuals with an optimal outcome from autism. NeuroImage Clinical 2015, 10: 182-191. PMID: 26862477, PMCID: PMC4707189, DOI: 10.1016/j.nicl.2015.11.014.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderTypical developmentTD groupBrain networksSentence comprehension taskIndividuals ages 8Functional MRI scansLanguage comprehensionASD groupComprehension taskLanguage abilityLateralized regionsLanguage performanceRight homologueOO individualsSpectrum disorderBrain functioningPosterior cingulateLanguage processingAge 8Temporal regionsBrain regionsBrain functionMinority of individualsIntensive learningPsychiatric Symptoms in Youth with a History of Autism and Optimal Outcome
Orinstein A, Tyson KE, Suh J, Troyb E, Helt M, Rosenthal M, Barton ML, Eigsti IM, Kelley E, Naigles L, Schultz RT, Stevens MC, Fein DA. Psychiatric Symptoms in Youth with a History of Autism and Optimal Outcome. Journal Of Autism And Developmental Disorders 2015, 45: 3703-3714. PMID: 26155764, PMCID: PMC4609588, DOI: 10.1007/s10803-015-2520-8.Peer-Reviewed Original ResearchConceptsHigh-functioning autismAutism spectrum disorderHFA groupPsychiatric disordersHistory of autismSocial phobiaSpectrum disorderSpecific phobiaParent interviewsGeneralized anxietyElevated depressionAge 8AutismDSM-IV psychiatric disordersSubthreshold symptomsOO groupPsychiatric symptomsPhobiaCurrent ADHDYouthDisordersOptimal outcomesADHDPsychopathologyAnxietySocial Function and Communication in Optimal Outcome Children and Adolescents with an Autism History on Structured Test Measures
Orinstein AJ, Suh J, Porter K, De Yoe KA, Tyson KE, Troyb E, Barton ML, Eigsti IM, Stevens MC, Fein DA. Social Function and Communication in Optimal Outcome Children and Adolescents with an Autism History on Structured Test Measures. Journal Of Autism And Developmental Disorders 2015, 45: 2443-2463. PMID: 25758821, PMCID: PMC4515156, DOI: 10.1007/s10803-015-2409-6.Peer-Reviewed Original ResearchConceptsHigh functioning autismOO participantsOptimal Outcome ChildrenPragmatic language deficitsAttentional problemsCommunication symptomsTD youthTD peersSocial abilitiesSocial difficultiesCommunicative impairmentsASD diagnosisLanguage deficitsOutcomes childrenTest measuresCommunication difficultiesGroup differencesSocial relationshipsYouthSocial functionParticipantsLess insightDifficultiesOptimal outcomesAutismRelationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents
Witt ST, Stevens MC. Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents. Psychiatry Research 2015, 232: 168-174. PMID: 25795595, PMCID: PMC4417010, DOI: 10.1016/j.pscychresns.2015.02.009.Peer-Reviewed Original ResearchCARES
Rogers S, Griffin L, Masso P, Stevens M, Mangini L, Smith S. CARES. Pediatric Emergency Care 2015, 31: 173-177. PMID: 25706924, DOI: 10.1097/pec.0000000000000378.Peer-Reviewed Original ResearchConceptsLength of stayMean LOSPediatric psychiatric emergenciesEmergency department visitsUnique patient visitsDepartment visitsPrimary outcomeED patientsPediatric EDRetrospective reviewCare unitPatient visitsPsychiatric illnessStudy populationPsychiatric emergenciesPsychiatric patientsPatientsTotal cost savingsVisitsCareAverage total costPost careUnique visitsSimilar ageChildren
2014
Brain activity in predominantly-inattentive subtype attention-deficit/hyperactivity disorder during an auditory oddball attention task
Orinstein AJ, Stevens MC. Brain activity in predominantly-inattentive subtype attention-deficit/hyperactivity disorder during an auditory oddball attention task. Psychiatry Research 2014, 223: 121-128. PMID: 24953999, PMCID: PMC4120259, DOI: 10.1016/j.pscychresns.2014.05.012.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAttention taskADHD subtypesHyperactivity disorderNovel stimuliBrain activityMemory-related cognitive processesPrevious functional neuroimaging studiesBilateral superior temporal gyrusRight posterior parietal cortexNumerous cognitive tasksFunctional neuroimaging studiesInfrequent target stimuliAge-matched control participantsSuperior temporal gyrusPosterior parietal cortexTemporal lobe structuresGreater hemodynamic activityAttentional orientingCognitive processesCognitive tasksTarget stimuliInattentive subtypeLateral temporal lobe structuresAttention deficits
2013
Academic abilities in children and adolescents with a history of autism spectrum disorders who have achieved optimal outcomes
Troyb E, Orinstein A, Tyson K, Helt M, Eigsti IM, Stevens M, Fein D. Academic abilities in children and adolescents with a history of autism spectrum disorders who have achieved optimal outcomes. Autism 2013, 18: 233-243. PMID: 24096312, PMCID: PMC4481875, DOI: 10.1177/1362361312473519.Peer-Reviewed Original ResearchConceptsAutism spectrum disorder diagnosisAutism spectrum disorderAcademic abilityAutism groupSpectrum disorderHigh-functioning individualsAverage rangeDisorder diagnosisNonverbal IQVerbal IQLanguage skillsSchool supportSubtestsIQComprehensionAdolescentsOngoing difficultiesOptimal outcomesPeersIndividualsMathematical problemDisordersChildrenAbilitySkillsLanguage and Verbal Memory in Individuals with a History of Autism Spectrum Disorders Who Have Achieved Optimal Outcomes
Tyson K, Kelley E, Fein D, Orinstein A, Troyb E, Barton M, Eigsti IM, Naigles L, Schultz RT, Stevens M, Helt M, Rosenthal M. Language and Verbal Memory in Individuals with a History of Autism Spectrum Disorders Who Have Achieved Optimal Outcomes. Journal Of Autism And Developmental Disorders 2013, 44: 648-663. PMID: 23982487, PMCID: PMC3948218, DOI: 10.1007/s10803-013-1921-9.Peer-Reviewed Original ResearchConceptsVerbal memoryTypical developmentAutism spectrum disorder diagnosisStrong language abilitiesAverage rangeAutism spectrum disorderLanguage measuresLanguage abilityTD groupVerbal IQHFA groupOO individualsSpectrum disorderSubtle weaknessDisorder diagnosisMemoryGreater relianceLanguageMean performanceIndividualsOptimal outcomesIQOO groupAutismMeasuresTime course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder
Yang H, Lu LH, Wu M, Stevens M, Wegbreit E, Fitzgerald J, Levitan B, Shankman S, Pavuluri MN. Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder. Journal Of Affective Disorders 2013, 150: 571-577. PMID: 23517886, PMCID: PMC3745513, DOI: 10.1016/j.jad.2013.02.007.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexPediatric bipolar disorderVentral lateral prefrontal cortexAnterior cingulate cortexHealthy controlsBipolar disorderLateral prefrontal cortexCortical regionsPrefrontal cortexRight dorsal lateral prefrontal cortexBilateral anterior cingulate cortexVentral cortical regionsFronto-limbic circuitsGreater activationPrefrontal cortex changesPresent findingsProlonged lengthMedication algorithmSubcortical changesUnmedicated patientsFronto-striatalPharmacological interventionsPBD groupSubcortical activityCingulate cortexThe role of top-down control in different phases of a sensorimotor timing task: a DCM study of adults and adolescents
Witt ST, Stevens MC. The role of top-down control in different phases of a sensorimotor timing task: a DCM study of adults and adolescents. Brain Imaging And Behavior 2013, 7: 260-273. PMID: 23475755, PMCID: PMC3743949, DOI: 10.1007/s11682-013-9224-5.Peer-Reviewed Original ResearchConceptsPrefrontal cortexLow-level sensorySignificant maturational effectsVentrolateral prefrontal cortexDynamic causal modelingInternal clock mechanismFinger-tapping taskCognitive controlSensorimotor timingBehavioral accuracyAuditory cuesTiming taskFMRI studyBaseline connectivitySensory regionsCognitive functionDCM studySensory stimuliCausal modelingAuditory cortexMotor regionsCuesBrain regionsAccurate performanceMotor controlOptimal outcome in individuals with a history of autism
Fein D, Barton M, Eigsti I, Kelley E, Naigles L, Schultz RT, Stevens M, Helt M, Orinstein A, Rosenthal M, Troyb E, Tyson K. Optimal outcome in individuals with a history of autism. Journal Of Child Psychology And Psychiatry 2013, 54: 195-205. PMID: 23320807, PMCID: PMC3547539, DOI: 10.1111/jcpp.12037.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSymptoms of ASDSpectrum disorderSocial interactionFace recognitionHistory of autismMore subtle aspectsNonverbal IQAutism symptomsOutcomes individualsTypical developmentLanguage subscaleHFA groupOO individualsRepetitive behaviorsGroup mean scoresCommunication impairmentsStandardized measuresSocial domainsPossible deficitsMinority of individualsMean scoreAutismSevere difficultiesSubtle aspects