2013
Functional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome
Worhunsky PD, Stevens MC, Carroll KM, Rounsaville BJ, Calhoun VD, Pearlson GD, Potenza MN. Functional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome. Psychology Of Addictive Behaviors 2013, 27: 477-488. PMID: 22775772, PMCID: PMC3743442, DOI: 10.1037/a0029092.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBehavior, AddictiveCase-Control StudiesCerebral CortexCocaine-Related DisordersCognitive Behavioral TherapyData Interpretation, StatisticalExecutive FunctionFemaleFunctional NeuroimagingHumansLimbic SystemLinear ModelsMagnetic Resonance ImagingMaleMotivationNerve NetOxygenPrincipal Component AnalysisPsychomotor PerformanceStroop TestTreatment OutcomeConceptsCognitive controlCocaine dependencePoor cognitive controlCognitive control processesFunctional networksTreatment retentionDistinct functional networksIndependent component analysisFunctional brain networksConflict monitoringStroop taskTreatment outcome measuresMotivational processingCocaine-dependent patientsPrefrontal networkBrain networksSubcortical networksFunctional connectivityControl participantsFMRI dataRegional activationReduced involvementCortical networksTreatment developmentControl processTask-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA
Xu J, Zhang S, Calhoun VD, Monterosso J, Li CS, Worhunsky PD, Stevens M, Pearlson GD, Potenza MN. Task-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA. NeuroImage 2013, 79: 62-71. PMID: 23611864, PMCID: PMC3677796, DOI: 10.1016/j.neuroimage.2013.04.038.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingCognitionFemaleHumansMaleNerve NetPattern Recognition, VisualPrincipal Component AnalysisTask Performance and AnalysisYoung AdultConceptsCommon brain regionsSpatial independent component analysisDifferent functional networksMedial frontoparietal corticesFunctional networksCognitive tasksBrain regionsFrontoparietal cortexMultiple cognitive processesFunctional magnetic resonance imaging (fMRI) dataHigher-order association corticesTask-related modulationSame brain regionsCognitive processesVisual tasksMagnetic resonance imaging dataVentral tegmental areaPosterior cingulateAssociation cortexHealthy participantsHuman brainTimecoursesSubcortical structuresSpatial ICATask
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regionsNeural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder
Ethridge LE, Hamm JP, Shapiro JR, Summerfelt AT, Keedy SK, Stevens MC, Pearlson G, Tamminga CA, Boutros NN, Sweeney JA, Keshavan MS, Thaker G, Clementz BA. Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder. Biological Psychiatry 2012, 72: 766-774. PMID: 22572033, PMCID: PMC3465513, DOI: 10.1016/j.biopsych.2012.03.034.Peer-Reviewed Original ResearchConceptsAuditory oddball taskBipolar disorderNeural responsesBest differentiated groupsSingular time pointsDifferent psychotic disordersAuditory processing abnormalitiesOddball taskPsychotic bipolar disorderP300 event-related potentialNonpsychotic patientsHealthy subjectsPsychotic disordersPsychosis groupAuditory oddball responsePsychotic groupSchizophreniaFrequent combinationTime pointsBrain activationNeural activationBeta activityGroup differencesBrain responsesDisordersA large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort
Meda SA, Narayanan B, Liu J, Perrone-Bizzozero NI, Stevens MC, Calhoun VD, Glahn DC, Shen L, Risacher SL, Saykin AJ, Pearlson GD. A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort. NeuroImage 2012, 60: 1608-1621. PMID: 22245343, PMCID: PMC3312985, DOI: 10.1016/j.neuroimage.2011.12.076.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainCanadaCohort StudiesData Interpretation, StatisticalFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMaleMultivariate AnalysisPolymorphism, Single NucleotidePrevalencePrincipal Component AnalysisReproducibility of ResultsSensitivity and SpecificityUnited StatesConceptsLate-onset Alzheimer's diseaseMagnetic resonance imagingAlzheimer's diseaseOnset Alzheimer's diseaseAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortElderly healthy controlsAmnestic mild cognitive impairmentDifferent brain regionsMild cognitive impairmentStructural MRI scansHealthy controlsCardiovascular diseaseInitiative cohortMRI scansPathologic processesCognitive impairmentResonance imagingBrain regionsSingle nucleotide polymorphism (SNP) variantsCaucasian adultsSubject cohortDiseasePhysiologic pathwaysCohortPolymorphism variants
2009
Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis
Meda SA, Stevens MC, Folley BS, Calhoun VD, Pearlson GD. Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis. PLOS ONE 2009, 4: e7911. PMID: 19936244, PMCID: PMC2775682, DOI: 10.1371/journal.pone.0007911.Peer-Reviewed Original ResearchConceptsTask accuracyFunctional connectivityPrefrontal cortexNetwork engagementLeft fronto-parietal networkRight dorsolateral prefrontal cortexMemory fMRI paradigmWorking Memory EncodingFronto-parietal networkVentrolateral prefrontal cortexNumerous neuroimaging studiesDorsolateral prefrontal cortexIndependent component analysisAbnormal regional brain activityDefault mode networkBrain network integrationDysfunctional brain regionsPrevious schizophrenia studiesRegional brain activityHippocampus/parahippocampusMemory encodingFMRI taskMemory cognitionMemory performanceFMRI paradigmInvestigating the behavioral and self-report constructs of impulsivity domains using principal component analysis
Meda SA, Stevens MC, Potenza MN, Pittman B, Gueorguieva R, Andrews MM, Thomas AD, Muska C, Hylton JL, Pearlson GD. Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis. Behavioural Pharmacology 2009, 20: 390-399. PMID: 19724194, PMCID: PMC3268653, DOI: 10.1097/fbp.0b013e32833113a3.Peer-Reviewed Original ResearchMeSH KeywordsAdultBehaviorFemaleHumansImpulsive BehaviorMaleMiddle AgedPrincipal Component AnalysisPsychometricsRisk-TakingSelf ConceptSubstance-Related DisordersSurveys and QuestionnairesYoung AdultConceptsSelf-report measuresImpulsivity domainsImpulsivity constructsSelf-reported impulsivityDistinct neural systemsAspects of impulsivitySelf-report constructsSelf-reported compulsivityMeasures of impulsivityReward/punishmentConstruct of impulsivitySupplementary goalCurrent cocaine usersTemporal discountingFive-factor solutionLaboratory tasksMaladaptive behaviorsDifferent domainsImpulsivityMultidimensional constructBehavioral activationNeural systemsHuman behaviorBehavioral studiesSupplemental analysesInvestigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls
Demirci O, Stevens MC, Andreasen NC, Michael A, Liu J, White T, Pearlson GD, Clark VP, Calhoun VD. Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. NeuroImage 2009, 46: 419-431. PMID: 19245841, PMCID: PMC2713821, DOI: 10.1016/j.neuroimage.2009.02.014.Peer-Reviewed Original ResearchConceptsFunctional network connectivitySternberg Item Recognition ParadigmTemporal lobe activationBrain networksBrain activation networksCerebral sitesHealthy controlsAuditory oddball taskPsychiatric disordersSchizophrenia patientsControl groupAOD taskCausal relationshipFMRI brain networksTime courseOddball task
2007
A method for functional network connectivity among spatially independent resting-state components in schizophrenia
Jafri MJ, Pearlson GD, Stevens M, Calhoun VD. A method for functional network connectivity among spatially independent resting-state components in schizophrenia. NeuroImage 2007, 39: 1666-1681. PMID: 18082428, PMCID: PMC3164840, DOI: 10.1016/j.neuroimage.2007.11.001.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFunctional connectivityTime courseICA time coursesHealthy controlsMagnetic resonance imaging dataHealthy individualsPatientsBrain disordersBrain regionsState fMRI dataCortical processingSchizophreniaFunctional magnetic resonance imaging (fMRI) dataSpatial independent component analysisSignificant differencesBrain networksComponent time coursesTemporal relationshipCoherent brain regionsBrainFMRI dataCourseImaging dataSeed voxelsBrain network dynamics during error commission
Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Brain network dynamics during error commission. Human Brain Mapping 2007, 30: 24-37. PMID: 17979124, PMCID: PMC2669663, DOI: 10.1002/hbm.20478.Peer-Reviewed Original ResearchConceptsError commissionGo/No-Go taskVisual Go/No-Go taskHigher-order cognitive controlFunctional magnetic resonance imaging (fMRI) dataLateral prefrontal cortexPrefrontal brain regionsWhole-brain functional connectivityPregenual cingulate cortexAnterior temporal lobeBrain network dynamicsInferior parietal lobuleAdult healthy participantsBrain functional connectivityCognitive controlIndependent component analysisButton pressHemodynamic activationAffective responsesDevelopmental differencesNeurobiological differencesParietal lobulePrefrontal cortexAnterior cingulateError detection networkFunctional neural networks underlying response inhibition in adolescents and adults
Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Functional neural networks underlying response inhibition in adolescents and adults. Behavioural Brain Research 2007, 181: 12-22. PMID: 17467816, PMCID: PMC2266817, DOI: 10.1016/j.bbr.2007.03.023.Peer-Reviewed Original ResearchConceptsResponse inhibition circuitsBehavioral performance changesBrain hemodynamic activityResponse inhibitionFronto-striatal regionsThalamic modulationThalamic connectivityAge-related differencesPremotor cortexHealthy adolescentsGo/No-Go taskNeural circuitsHemodynamic activityEffective connectivity analysisInhibition circuitAdultsFunctional neural networksResponse suppressionAdolescentsConnectivity analysisFirst descriptionInhibitionNetwork engagement
2006
Functional neural circuits for mental timekeeping
Stevens MC, Kiehl KA, Pearlson G, Calhoun VD. Functional neural circuits for mental timekeeping. Human Brain Mapping 2006, 28: 394-408. PMID: 16944489, PMCID: PMC6871423, DOI: 10.1002/hbm.20285.Peer-Reviewed Original ResearchConceptsTiming taskFrontostriatal networkDifferent information processing stagesFunctional magnetic resonance imaging (fMRI) dataInformation processing stagesInformation processing modelPutamen/globus pallidusBilateral anterior insulaInterval timing taskSuperior temporal gyrusHemodynamic signal changesDistinct neural circuitsNeural circuitsPerformance of tasksIndependent component analysisAnterior cingulate gyrusSupplementary motor areaAnterior insulaFrontostriatal circuitsSupramarginal gyrusNeurobiological substratesTemporal gyrusMagnetic resonance imaging dataProcessing modelFunctional connectivity
2005
Semi-blind ICA of fMRI: A method for utilizing hypothesis-derived time courses in a spatial ICA analysis
Calhoun VD, Adali T, Stevens MC, Kiehl KA, Pekar JJ. Semi-blind ICA of fMRI: A method for utilizing hypothesis-derived time courses in a spatial ICA analysis. NeuroImage 2005, 25: 527-538. PMID: 15784432, DOI: 10.1016/j.neuroimage.2004.12.012.Peer-Reviewed Original ResearchMeSH KeywordsAuditory PerceptionBrainHumansMagnetic Resonance ImagingPrincipal Component AnalysisTimeConceptsPrior informationIndependent component analysisData analysis applicationsSemi-blind independent component analysisData-driven approachThree-stimulus auditory oddball paradigmTemporal constraintsAnalysis applicationsICA analysisTime-course informationFlexible wayPresence of noiseCourse informationRegression approachSimulation resultsBlind source separation techniqueExplicit constraintsFlexible modeling approachFMRI dataSource separation techniquesInformationUseful applicationsHigher order statistical momentsModeling approachNegative associates