2021
Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
Li T, van Rooij D, Mota N, Buitelaar J, Ambrosino S, Banaschewski T, Bandeira C, Bau C, Baumeister S, Baur‐Streubel R, Bellgrove M, Biederman J, Bralten J, Bramati I, Brandeis D, Berm S, Busatto G, Calvo A, Castellanos F, Cercignani M, Chantiluke K, Christakou A, Coghill D, Conzelmann A, Cubillo A, Cupertino R, de Zeeuw P, Durston S, Earl E, Epstein J, Ethofer T, Fallgatter A, Fair D, Faraone S, Frodl T, Gabel M, Gogberashvili T, Grevet E, Haavik J, Harrison N, Hartman C, Heslenfeld D, Hoekstra P, Høvik M, Jahanshad N, Kardatzki B, Karkashadze G, Kelly C, Kohls G, Konrad K, Kuntsi J, Lazaro L, Lera‐Miguel S, Lesch K, Louza M, Lundervold A, Malpas C, Mattos P, McCarthy H, Nicolau R, Nigg J, Tuura R, Oosterlaan J, Oranje B, Paloyelis Y, Pauli P, Picon F, Plessen K, Ramos‐Quiroga J, Reif A, Reneman L, Rosa P, Rubia K, Schrantee A, Schweren L, Seitz J, Shaw P, Silk T, Skokauskas N, Vila J, Soloveva A, Stevens M, Sudre G, Tamm L, Thompson P, Tovar‐Moll F, van Erp T, Vance A, Vilarroya O, Vives‐Gilabert Y, von Polier G, Walitza S, Yoncheva Y, Zanetti M, Ziegler G, Anikin A, Asherson P, Baranov A, Chaim‐Avanicini T, Dale A, Doyle A, Jernigan T, Hohmann S, Kapilushniy D, Mehta M, Namazova‐Baranova L, Novotny S, Weiss E, Schwarz L, Hoogman M, Vasquez A, Franke B. Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes. Journal Of Child Psychology And Psychiatry 2021, 62: 1140-1149. PMID: 33786843, PMCID: PMC8403135, DOI: 10.1111/jcpp.13384.Peer-Reviewed Original Research
2019
Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples
Hoogman M, Muetzel R, Guimaraes J, Shumskaya E, Mennes M, Zwiers M, Jahanshad N, Sudre G, Wolfers T, Earl E, Soliva Vila J, Vives-Gilabert Y, Khadka S, Novotny S, Hartman C, Heslenfeld D, Schweren L, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini T, Rosa P, Zanetti M, Malpas C, Kohls G, von Polier G, Seitz J, Biederman J, Doyle A, Dale A, van Erp T, Epstein J, Jernigan T, Baur-Streubel R, Ziegler G, Zierhut K, Schrantee A, Høvik M, Lundervold A, Kelly C, McCarthy H, Skokauskas N, O’Gorman Tuura R, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke K, Christakou A, Vance A, Cercignani M, Gabel M, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati I, Tovar-Moll F, Fallgatter A, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen K, Kuntsi J, Mehta M, Paloyelis Y, Harrison N, Bellgrove M, Silk T, Cubillo A, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos F, Yoncheva Y, Haavik J, Reneman L, Conzelmann A, Lesch K, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Busatto G, Louza M, Durston S, Hoekstra P, Oosterlaan J, Stevens M, Ramos-Quiroga J, Vilarroya O, Fair D, Nigg J, Thompson P, Buitelaar J, Faraone S, Shaw P, Tiemeier H, Bralten J, Franke B. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples. American Journal Of Psychiatry 2019, 176: 531-542. PMID: 31014101, PMCID: PMC6879185, DOI: 10.1176/appi.ajp.2019.18091033.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCortical measuresDeficit hyperactivity disorderChild Behavior ChecklistAdult groupAttention ScaleADHD symptomsAttention problemsCortical thicknessFusiform gyrusHyperactivity disorderADHD diagnosisCortical surface areaLifespan trajectoriesBehavior ChecklistFamilial effectsFuture longitudinal studiesTemporal regionsNeuroimage studiesBrain regionsLarge significant effectLow surface area valuesLongitudinal studyAdolescentsFrontal cortex
2015
Psychiatric Symptoms in Youth with a History of Autism and Optimal Outcome
Orinstein A, Tyson KE, Suh J, Troyb E, Helt M, Rosenthal M, Barton ML, Eigsti IM, Kelley E, Naigles L, Schultz RT, Stevens MC, Fein DA. Psychiatric Symptoms in Youth with a History of Autism and Optimal Outcome. Journal Of Autism And Developmental Disorders 2015, 45: 3703-3714. PMID: 26155764, PMCID: PMC4609588, DOI: 10.1007/s10803-015-2520-8.Peer-Reviewed Original ResearchConceptsHigh-functioning autismAutism spectrum disorderHFA groupPsychiatric disordersHistory of autismSocial phobiaSpectrum disorderSpecific phobiaParent interviewsGeneralized anxietyElevated depressionAge 8AutismDSM-IV psychiatric disordersSubthreshold symptomsOO groupPsychiatric symptomsPhobiaCurrent ADHDYouthDisordersOptimal outcomesADHDPsychopathologyAnxiety
2013
Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Research 2013, 221: 142-148. PMID: 24389161, PMCID: PMC3946244, DOI: 10.1016/j.pscychresns.2013.11.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGo/NoGo taskFunctional magnetic resonance imagingOCD patientsHD patientsResponse inhibitionNoGo taskHealthy controlsGo/NoGo task performanceDistinct neural underpinningsRight orbitofrontal gyrusErrors of commissionNeural underpinningsOrbitofrontal activationTask performanceCorrect rejectsMagnetic resonance imagingHemodynamic activityFrontal hypoactivityNeural activityOrbitofrontal gyrusBehavioral dataHemodynamic responsePatientsPreliminary evidenceAcademic abilities in children and adolescents with a history of autism spectrum disorders who have achieved optimal outcomes
Troyb E, Orinstein A, Tyson K, Helt M, Eigsti IM, Stevens M, Fein D. Academic abilities in children and adolescents with a history of autism spectrum disorders who have achieved optimal outcomes. Autism 2013, 18: 233-243. PMID: 24096312, PMCID: PMC4481875, DOI: 10.1177/1362361312473519.Peer-Reviewed Original ResearchConceptsAutism spectrum disorder diagnosisAutism spectrum disorderAcademic abilityAutism groupSpectrum disorderHigh-functioning individualsAverage rangeDisorder diagnosisNonverbal IQVerbal IQLanguage skillsSchool supportSubtestsIQComprehensionAdolescentsOngoing difficultiesOptimal outcomesPeersIndividualsMathematical problemDisordersChildrenAbilitySkillsFunctional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome
Worhunsky PD, Stevens MC, Carroll KM, Rounsaville BJ, Calhoun VD, Pearlson GD, Potenza MN. Functional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome. Psychology Of Addictive Behaviors 2013, 27: 477-488. PMID: 22775772, PMCID: PMC3743442, DOI: 10.1037/a0029092.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBehavior, AddictiveCase-Control StudiesCerebral CortexCocaine-Related DisordersCognitive Behavioral TherapyData Interpretation, StatisticalExecutive FunctionFemaleFunctional NeuroimagingHumansLimbic SystemLinear ModelsMagnetic Resonance ImagingMaleMotivationNerve NetOxygenPrincipal Component AnalysisPsychomotor PerformanceStroop TestTreatment OutcomeConceptsCognitive controlCocaine dependencePoor cognitive controlCognitive control processesFunctional networksTreatment retentionDistinct functional networksIndependent component analysisFunctional brain networksConflict monitoringStroop taskTreatment outcome measuresMotivational processingCocaine-dependent patientsPrefrontal networkBrain networksSubcortical networksFunctional connectivityControl participantsFMRI dataRegional activationReduced involvementCortical networksTreatment developmentControl processEffects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism.
Narayanan B, Stevens MC, Jiantonio RE, Krystal JH, Pearlson GD. Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism. Journal Of Studies On Alcohol And Drugs 2013, 74: 245-57. PMID: 23384372, PMCID: PMC3568163, DOI: 10.15288/jsad.2013.74.245.Peer-Reviewed Original ResearchConceptsNMDA receptor functionFHN subjectsFamily historyReceptor functionFHP individualsAlpha activityN-methyl-D-aspartate receptor functionNMDA receptor antagonist memantineEffects of memantineAuditory oddball discrimination taskPositive family historyFamily history-negative subjectsEvent-related potentialsAlcoholism family historyCortical information processingOddball discrimination taskFHN individualsMemantine administrationAcute effectsDrug interactionsP3b amplitudeFHP subjectsMemantineSeparate occasionsTheta activity
2012
Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder
Passarotti AM, Ellis J, Wegbreit E, Stevens MC, Pavuluri MN. Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder. Brain Connectivity 2012, 2: 320-334. PMID: 23035965, PMCID: PMC3621331, DOI: 10.1089/brain.2012.0089.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexPediatric bipolar disorderRight ventrolateral prefrontal cortexWorking Memory NetworkFunctional connectivityMemory taskDorsolateral PFCBrain networksRight amygdalaMemory networkEmotion processing regionsEmotion regulation regionsDifferential functional connectivityFunctional magnetic resonanceBilateral temporal regionsConnected brain networksRegulation regionRegional functional connectivityNeutral facesEmotion processingCognitive processesEmotion evaluationPrefrontal regionsProcessing regionsBipolar disorderDifferences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives
Meda SA, Gill A, Stevens MC, Lorenzoni RP, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, Thaker G, Pearlson GD. Differences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives. Biological Psychiatry 2012, 71: 881-889. PMID: 22401986, PMCID: PMC3968680, DOI: 10.1016/j.biopsych.2012.01.025.Peer-Reviewed Original ResearchConceptsUnaffected first-degree relativesFirst-degree relativesPsychotic bipolar probandsBipolar probandsNegative Syndrome Scale (PANSS) scoresBipolar disorder shareFunctional brain dysconnectivityIndividual resting-state networksFunctional network connectivity analysisPANSS negative scoresResting-state networksFunctional network connectivityFunctional magnetic resonanceControl subjectsBrain dysconnectivityDisorder sharesHealthy subjectsBipolar relativesParalimbic circuitsScale scoreConnectivity differencesClinical relationshipSchizophreniaAbnormal pairsProbandsDiminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Potenza MN. Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling. Biological Psychiatry 2012, 71: 749-757. PMID: 22336565, PMCID: PMC3460522, DOI: 10.1016/j.biopsych.2012.01.006.Peer-Reviewed Original ResearchConceptsAlcohol dependencePathological gamblingVentral striatumMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studyBrain activation changesMonetary incentive delay taskReward processingLoss processingPresent functional magnetic resonance imaging (fMRI) studyControl comparison groupIncentive delay taskVentral striatal activationPG groupMonetary rewardsVentromedial prefrontal cortexSimilar associationImaging studiesFrontostriatal activityLoss anticipationConsistent alterationsActivation changesPrefrontal cortexLevels of impulsivity
2011
An Initial Study of Neural Responses to Monetary Incentives as Related to Treatment Outcome in Cocaine Dependence
Jia Z, Worhunsky PD, Carroll KM, Rounsaville BJ, Stevens MC, Pearlson GD, Potenza MN. An Initial Study of Neural Responses to Monetary Incentives as Related to Treatment Outcome in Cocaine Dependence. Biological Psychiatry 2011, 70: 553-560. PMID: 21704307, PMCID: PMC3162064, DOI: 10.1016/j.biopsych.2011.05.008.Peer-Reviewed Original ResearchConceptsRight ventral striatumVentral striatumCocaine dependenceRight insulaMonetary incentive delay taskRight caudateReward-based decisionIncentive delay taskTreatment retentionFunctional magnetic resonanceCD participantsMedial frontal gyrusRight thalamusUrine toxicologyTreatment outcomesReward anticipationReward processingDelay taskTask performanceFrontal gyrusGreater activationNeural responsesRewarding outcomesRight subcallosal gyrusMonetary rewards
2010
Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach
Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, Pearlson G. Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach. Biological Psychiatry 2010, 68: 61-69. PMID: 20497901, PMCID: PMC2900394, DOI: 10.1016/j.biopsych.2010.03.035.Peer-Reviewed Original ResearchConceptsBrain connectivityFunctional connectivitySchizophrenia patientsAnatomical connectivityState functional magnetic resonance imagingFunctional connectivity alterationsHealthy control subjectsClinical symptom severityGroup differencesAnatomical connectivity mapsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexGlobal connectivity analysisClinical symptomsWhite matter anatomyControl subjectsConnectivity alterationsCingulate cortexPatientsResonance imagingBrain regionsSymptom severityDMN componentsTask-positive network
2009
Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis
Meda SA, Stevens MC, Folley BS, Calhoun VD, Pearlson GD. Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis. PLOS ONE 2009, 4: e7911. PMID: 19936244, PMCID: PMC2775682, DOI: 10.1371/journal.pone.0007911.Peer-Reviewed Original ResearchConceptsTask accuracyFunctional connectivityPrefrontal cortexNetwork engagementLeft fronto-parietal networkRight dorsolateral prefrontal cortexMemory fMRI paradigmWorking Memory EncodingFronto-parietal networkVentrolateral prefrontal cortexNumerous neuroimaging studiesDorsolateral prefrontal cortexIndependent component analysisAbnormal regional brain activityDefault mode networkBrain network integrationDysfunctional brain regionsPrevious schizophrenia studiesRegional brain activityHippocampus/parahippocampusMemory encodingFMRI taskMemory cognitionMemory performanceFMRI paradigm
2005
Abnormal hemodynamics in schizophrenia during an auditory oddball task
Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.Peer-Reviewed Original ResearchConceptsAuditory oddball taskHealthy participantsOddball taskThree-stimulus auditory oddball taskDiffuse brain abnormalitiesHealthy control subjectsNovelty processingWidespread pathologic processCerebral areasControl subjectsBrain abnormalitiesMagnetic resonance imaging dataAbnormal hemodynamicsPathologic processesSchizophrenia patientsParietal cortexCognitive functionHeterogeneous disorderCerebellar circuitsSchizophreniaAbnormalitiesSignificant activationSubcortical systemsFunctional magnetic resonance imaging (fMRI) dataPatients
2000
Season of Birth Effects in Autism
Stevens MC, Fein DH, Waterhouse LH. Season of Birth Effects in Autism. Journal Of Clinical And Experimental Neuropsychology 2000, 22: 399-407. PMID: 10855047, DOI: 10.1076/1380-3395(200006)22:3;1-v;ft399.Peer-Reviewed Original Research