2024
Functional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance
Feng A, Zhi D, Feng Y, Jiang R, Fu Z, Xu M, Zhao M, Yu S, Stevens M, Sun L, Calhoun V, Sui J. Functional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance. EClinicalMedicine 2024, 77: 102876. DOI: 10.1016/j.eclinm.2024.102876.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderAttention deficit hyperactivity disorder patientsFunctional network connectivityAttention Deficit Hyperactivity Disorder AdolescentTreatment of attention deficit hyperactivity disorderPeking University Sixth HospitalBackground Attention deficit hyperactivity disorderDeficit hyperactivity disorderTreated with methylphenidateADHD subtypesHyperactivity/impulsivity symptomsAdolescent brainMedical treatment effectsHyperactivity disorderCognitive performanceABCD studyProblem scoresNeuroimaging markersNeurodevelopmental disordersMedical treatmentChildhood onsetChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaNatural Science Foundation of ChinaPrimary medication75. Executive Working Memory Intervention Reduces Motor Activity in Adolescents With Attention-Deficit Hyperactivity Disorder
Beatty M, Sullivan A, Anderson J, Choi J, Pearlson G, Hawkins K, Bond D, Stevens M. 75. Executive Working Memory Intervention Reduces Motor Activity in Adolescents With Attention-Deficit Hyperactivity Disorder. Biological Psychiatry 2024, 95: s130. DOI: 10.1016/j.biopsych.2024.02.310.Peer-Reviewed Original Research
2020
Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups
Boedhoe PSW, van Rooij D, Hoogman M, Twisk JWR, Schmaal L, Abe Y, Alonso P, Ameis SH, Anikin A, Anticevic A, Arango C, Arnold PD, Asherson P, Assogna F, Auzias G, Banaschewski T, Baranov A, Batistuzzo MC, Baumeister S, Baur-Streubel R, Behrmann M, Bellgrove MA, Benedetti F, Beucke JC, Biederman J, Bollettini I, Bose A, Bralten J, Bramati IE, Brandeis D, Brem S, Brennan BP, Busatto GF, Calderoni S, Calvo A, Calvo R, Castellanos FX, Cercignani M, Chaim-Avancini TM, Chantiluke KC, Cheng Y, Cho KIK, Christakou A, Coghill D, Conzelmann A, Cubillo AI, Dale AM, Dallaspezia S, Daly E, Denys D, Deruelle C, Di Martino A, Dinstein I, Doyle AE, Durston S, Earl EA, Ecker C, Ehrlich S, Ely BA, Epstein JN, Ethofer T, Fair DA, Fallgatter AJ, Faraone SV, Fedor J, Feng X, Feusner JD, Fitzgerald J, Fitzgerald KD, Fouche JP, Freitag CM, Fridgeirsson EA, Frodl T, Gabel MC, Gallagher L, Gogberashvili T, Gori I, Gruner P, Gürsel DA, Haar S, Haavik J, Hall GB, Harrison NA, Hartman CA, Heslenfeld DJ, Hirano Y, Hoekstra PJ, Hoexter MQ, Hohmann S, Høvik MF, Hu H, Huyser C, Jahanshad N, Jalbrzikowski M, James A, Janssen J, Jaspers-Fayer F, Jernigan TL, Kapilushniy D, Kardatzki B, Karkashadze G, Kathmann N, Kaufmann C, Kelly C, Khadka S, King JA, Koch K, Kohls G, Konrad K, Kuno M, Kuntsi J, Kvale G, Kwon JS, Lázaro L, Lera-Miguel S, Lesch KP, Hoekstra L, Liu Y, Lochner C, Louza MR, Luna B, Lundervold AJ, Malpas CB, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Mattos P, McCarthy H, McGrath J, Mehta MA, Menchón JM, Mennes M, Martinho MM, Moreira PS, Morer A, Morgado P, Muratori F, Murphy CM, Murphy DGM, Nakagawa A, Nakamae T, Nakao T, Namazova-Baranova L, Narayanaswamy JC, Nicolau R, Nigg JT, Novotny SE, Nurmi EL, Weiss EO, O'Gorman Tuura RL, O'Hearn K, O'Neill J, Oosterlaan J, Oranje B, Paloyelis Y, Parellada M, Pauli P, Perriello C, Piacentini J, Piras F, Piras F, Plessen KJ, Puig O, Ramos-Quiroga JA, Reddy YCJ, Reif A, Reneman L, Retico A, Rosa PGP, Rubia K, Rus OG, Sakai Y, Schrantee A, Schwarz L, Schweren LJS, Seitz J, Shaw P, Shook D, Silk TJ, Simpson HB, Skokauskas N, Soliva Vila JC, Solovieva A, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Sudre G, Szeszko PR, Tamm L, Taylor MJ, Tolin DF, Tosetti M, Tovar-Moll F, Tsuchiyagaito A, van Erp TGM, van Wingen GA, Vance A, Venkatasubramanian G, Vilarroya O, Vives-Gilabert Y, von Polier GG, Walitza S, Wallace GL, Wang Z, Wolfers T, Yoncheva YN, Yun JY, Zanetti MV, Zhou F, Ziegler GC, Zierhut KC, Zwiers MP, Thompson P, Stein D, Buitelaar J, Franke B, van den Heuvel O. Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups. American Journal Of Psychiatry 2020, 177: 834-843. PMID: 32539527, PMCID: PMC8296070, DOI: 10.1176/appi.ajp.2020.19030331.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAutism spectrum disorderObsessive-compulsive disorderDeficit hyperactivity disorderFrontal cortexCommon neurodevelopmental disorderStandardized processing protocolsStructural brain differencesCortical thickness differencesWhole-brain MRI dataCortical thicknessHyperactivity disorderCortical surface areaSpectrum disorderBrain differencesSmaller hippocampal volumesDifferent age groupsRegional cortical thicknessSubcortical brain volumesClinical groupsStructural brainSmaller intracranial volumeShared differenceNeurodevelopmental disordersHippocampal differences
2019
Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples
Hoogman M, Muetzel R, Guimaraes J, Shumskaya E, Mennes M, Zwiers M, Jahanshad N, Sudre G, Wolfers T, Earl E, Soliva Vila J, Vives-Gilabert Y, Khadka S, Novotny S, Hartman C, Heslenfeld D, Schweren L, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini T, Rosa P, Zanetti M, Malpas C, Kohls G, von Polier G, Seitz J, Biederman J, Doyle A, Dale A, van Erp T, Epstein J, Jernigan T, Baur-Streubel R, Ziegler G, Zierhut K, Schrantee A, Høvik M, Lundervold A, Kelly C, McCarthy H, Skokauskas N, O’Gorman Tuura R, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke K, Christakou A, Vance A, Cercignani M, Gabel M, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati I, Tovar-Moll F, Fallgatter A, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen K, Kuntsi J, Mehta M, Paloyelis Y, Harrison N, Bellgrove M, Silk T, Cubillo A, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos F, Yoncheva Y, Haavik J, Reneman L, Conzelmann A, Lesch K, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Busatto G, Louza M, Durston S, Hoekstra P, Oosterlaan J, Stevens M, Ramos-Quiroga J, Vilarroya O, Fair D, Nigg J, Thompson P, Buitelaar J, Faraone S, Shaw P, Tiemeier H, Bralten J, Franke B. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples. American Journal Of Psychiatry 2019, 176: 531-542. PMID: 31014101, PMCID: PMC6879185, DOI: 10.1176/appi.ajp.2019.18091033.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCortical measuresDeficit hyperactivity disorderChild Behavior ChecklistAdult groupAttention ScaleADHD symptomsAttention problemsCortical thicknessFusiform gyrusHyperactivity disorderADHD diagnosisCortical surface areaLifespan trajectoriesBehavior ChecklistFamilial effectsFuture longitudinal studiesTemporal regionsNeuroimage studiesBrain regionsLarge significant effectLow surface area valuesLongitudinal studyAdolescentsFrontal cortex
2015
A preliminary study of the effects of working memory training on brain function
Stevens MC, Gaynor A, Bessette KL, Pearlson GD. A preliminary study of the effects of working memory training on brain function. Brain Imaging And Behavior 2015, 10: 387-407. PMID: 26138580, PMCID: PMC4698365, DOI: 10.1007/s11682-015-9416-2.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderWM trainingMemory trainingBrain regionsDifferent neural correlatesBrain functionADHD symptom severityTraining-related changesTemporal lobe regionsDifferent symptom typesWM abilityExecutive processingWM performanceFMRI taskFrontoparietal circuitsNeural correlatesBrain activationHyperactivity disorderNeuropsychological testsNeural changesBrain activityTask phasesLobe regionsActivation gainControl participants
2014
Brain activity in predominantly-inattentive subtype attention-deficit/hyperactivity disorder during an auditory oddball attention task
Orinstein AJ, Stevens MC. Brain activity in predominantly-inattentive subtype attention-deficit/hyperactivity disorder during an auditory oddball attention task. Psychiatry Research 2014, 223: 121-128. PMID: 24953999, PMCID: PMC4120259, DOI: 10.1016/j.pscychresns.2014.05.012.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAttention taskADHD subtypesHyperactivity disorderNovel stimuliBrain activityMemory-related cognitive processesPrevious functional neuroimaging studiesBilateral superior temporal gyrusRight posterior parietal cortexNumerous cognitive tasksFunctional neuroimaging studiesInfrequent target stimuliAge-matched control participantsSuperior temporal gyrusPosterior parietal cortexTemporal lobe structuresGreater hemodynamic activityAttentional orientingCognitive processesCognitive tasksTarget stimuliInattentive subtypeLateral temporal lobe structuresAttention deficits
2012
Neuropsychological Assessment and The Paradox of ADHD
Koziol L, Stevens M. Neuropsychological Assessment and The Paradox of ADHD. Applied Neuropsychology Child 2012, 1: 79-89. PMID: 23428294, DOI: 10.1080/21622965.2012.694764.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCauses of ADHDBrain network studiesHyperactivity disorderNeuropsychological testsFunctional neuroanatomyNeuropsychological assessmentNeuropsychological evaluationMental disorder diagnosesDimensional approachDisorder diagnosisResearch paradigmStatistical ManualDiagnostic assessmentDisordersNeuropsychologistsNeuroanatomyParadigmNetwork studiesTopical reviewClinical settingClinical diagnosisDiagnosis
2011
The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder
Wong CG, Stevens MC. The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2011, 71: 458-466. PMID: 22209640, PMCID: PMC4120250, DOI: 10.1016/j.biopsych.2011.11.011.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional magnetic resonance imagingFunctional connectivityFMRI taskHyperactivity disorderStimulant medicationNetwork engagementMemory fMRI taskFrontoparietal brain networksBrain regionsFrontoparietal brain regionsConnectivity changesMemory reaction timeVentrolateral prefrontal cortexAdditional brain regionsGroup independent component analysisMedication-related changesFunctional connectivity analysisRegional functional connectivityFunctional connectivity changesMemory performanceRepeated-measures t-testBrain activationIndependent component analysisRetrieval phase
2007
An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder
Stevens MC, Pearlson GD, Kiehl KA. An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2007, 164: 1737-1749. PMID: 17974940, DOI: 10.1176/appi.ajp.2007.06050876.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdolescentAdolescent BehaviorAttentionAttention Deficit Disorder with HyperactivityAuditory PerceptionBrainBrain MappingCerebral CortexChildCognition DisordersDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsHemodynamicsHumansMagnetic Resonance ImagingMaleMemory DisordersOrientationOxygenPsychiatric Status Rating ScalesPsychomotor PerformanceConceptsAttention deficit hyperactivity disorderEvent-related potentialsFunctional magnetic resonance imagingDeficit hyperactivity disorderBrain regionsHyperactivity disorderHemodynamic activityThree-stimulus auditory oddball taskP3 event-related potentialEvent-related fMRI dataProcessing of targetsAbnormal hemodynamic activityWorking Memory DeficitsSlower task performanceAuditory oddball taskNovel environmental stimuliCortical brain regionsAttentional orientingOrient attentionADHD participantsCognitive processesCognitive representationsOddball studiesNeurobiological theoriesOddball stimuli
2002
A Review of Adult ADHD: A Neuropsychological and Neuroimaging Perspective
Kaplan R, Stevens M. A Review of Adult ADHD: A Neuropsychological and Neuroimaging Perspective. CNS Spectrums 2002, 7: 355-362. PMID: 15122107, DOI: 10.1017/s1092852900017818.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderAdult attention-deficit/hyperactivity disorderPathophysiology of ADHDFunctional magnetic resonance imagingFrontal lobe functionNeuropsychological test performanceCore ADHD symptomsPsychiatric disordersSimilar psychiatric disordersNeuroimaging PerspectiveADHD symptomsLobe functionHyperactivity disorderNeuropsychological testsTest performanceNeuroimaging technologiesDevelopmental disordersMost theoriesUnitary disorderStatistical ManualMental disordersFourth EditionDisordersDopaminergic transmissionCurrent thinking