2012
Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder
Ethridge LE, Hamm JP, Shapiro JR, Summerfelt AT, Keedy SK, Stevens MC, Pearlson G, Tamminga CA, Boutros NN, Sweeney JA, Keshavan MS, Thaker G, Clementz BA. Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder. Biological Psychiatry 2012, 72: 766-774. PMID: 22572033, PMCID: PMC3465513, DOI: 10.1016/j.biopsych.2012.03.034.Peer-Reviewed Original ResearchConceptsAuditory oddball taskBipolar disorderNeural responsesBest differentiated groupsSingular time pointsDifferent psychotic disordersAuditory processing abnormalitiesOddball taskPsychotic bipolar disorderP300 event-related potentialNonpsychotic patientsHealthy subjectsPsychotic disordersPsychosis groupAuditory oddball responsePsychotic groupSchizophreniaFrequent combinationTime pointsBrain activationNeural activationBeta activityGroup differencesBrain responsesDisorders
2010
Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task
Witt ST, Lovejoy DW, Pearlson GD, Stevens MC. Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task. Brain Imaging And Behavior 2010, 4: 232-247. PMID: 20703959, DOI: 10.1007/s11682-010-9102-3.Peer-Reviewed Original ResearchConceptsMild TBI patientsMild traumatic brain injuryTraumatic brain injuryBrain activityRight dorsolateral prefrontal cortexActive information maintenanceCompensatory brain activityDefault mode network dysfunctionPrefrontal cortex activityAuditory oddball taskDorsolateral prefrontal cortexTBI patientsPersistent cognitive deficitsBrain injurySimilar topographical patternEffortful formsExecutive tasksExecutive abilitiesOddball taskTask performanceMental effortNovel stimuliStimulus detectionCortex activityPrefrontal cortex
2009
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationBrain MappingBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsEndophenotypesFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysPilot ProjectsPolymorphism, Single NucleotideSchizophreniaSerotonin Plasma Membrane Transport ProteinsConceptsDopamine transporterBrain functionNeurotropic factorAuditory oddball taskSchizophrenia patientsSingle nucleotide polymorphismsMultiple risk genesRisk genesOddball taskRelated brain functionsHealthy controlsSchizophrenia risk genesAbnormal activationGenomic factorsTemporal gyrusPatientsTask-relevant regionsSchizophreniaSignificant differencesAttention/Multiple single nucleotide polymorphismsGenetic profilePsychiatric neuroimagingBrainGenotype-phenotype relationshipsInvestigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls
Demirci O, Stevens MC, Andreasen NC, Michael A, Liu J, White T, Pearlson GD, Clark VP, Calhoun VD. Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. NeuroImage 2009, 46: 419-431. PMID: 19245841, PMCID: PMC2713821, DOI: 10.1016/j.neuroimage.2009.02.014.Peer-Reviewed Original ResearchConceptsFunctional network connectivitySternberg Item Recognition ParadigmTemporal lobe activationBrain networksBrain activation networksCerebral sitesHealthy controlsAuditory oddball taskPsychiatric disordersSchizophrenia patientsControl groupAOD taskCausal relationshipFMRI brain networksTime courseOddball task
2007
An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder
Stevens MC, Pearlson GD, Kiehl KA. An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2007, 164: 1737-1749. PMID: 17974940, DOI: 10.1176/appi.ajp.2007.06050876.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdolescentAdolescent BehaviorAttentionAttention Deficit Disorder with HyperactivityAuditory PerceptionBrainBrain MappingCerebral CortexChildCognition DisordersDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsHemodynamicsHumansMagnetic Resonance ImagingMaleMemory DisordersOrientationOxygenPsychiatric Status Rating ScalesPsychomotor PerformanceConceptsAttention deficit hyperactivity disorderEvent-related potentialsFunctional magnetic resonance imagingDeficit hyperactivity disorderBrain regionsHyperactivity disorderHemodynamic activityThree-stimulus auditory oddball taskP3 event-related potentialEvent-related fMRI dataProcessing of targetsAbnormal hemodynamic activityWorking Memory DeficitsSlower task performanceAuditory oddball taskNovel environmental stimuliCortical brain regionsAttentional orientingOrient attentionADHD participantsCognitive processesCognitive representationsOddball studiesNeurobiological theoriesOddball stimuli
2005
fMRI in an oddball task: Effects of target‐to‐target interval
Stevens MC, Calhoun VD, Kiehl KA. fMRI in an oddball task: Effects of target‐to‐target interval. Psychophysiology 2005, 42: 636-642. PMID: 16364059, DOI: 10.1111/j.1469-8986.2005.00368.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEvent-related potentialsTarget stimuliOddball taskTarget intervalTask-relevant target stimuliP3 event-related potentialBilateral lateral prefrontal cortexTask-relevant stimuliTemporal-parietal junctionLateral prefrontal cortexAuditory oddball taskMemory templateNovel stimuliPrefrontal cortexHemodynamic activityAnterior cingulateNeural systemsStimuliPositive relationshipLarge sampleHealthy adultsNeuronal modulationEffect of targetMagnetic resonance imagingThe hemodynamics of oddball processing during single-tone and two-tone target detection tasks
Stevens MC, Laurens KR, Liddle PF, Kiehl KA. The hemodynamics of oddball processing during single-tone and two-tone target detection tasks. International Journal Of Psychophysiology 2005, 60: 292-303. PMID: 16213043, PMCID: PMC2766532, DOI: 10.1016/j.ijpsycho.2005.07.012.Peer-Reviewed Original ResearchConceptsContextual manipulationsStimulus processingOddball taskTwo-tone auditory oddball taskEvent-related potential studySalient stimuli processingTarget stimulus processingBilateral temporal cortexTarget detection taskAuditory oddball taskLateral frontal cortexERP componentsReflexive processingSalient stimuliStimulus typeERP dataTask performanceFMRI studyStimulus classesDetection taskNeurocognitive functionSubcortical networksNeural systemsPotential studiesTemporal cortexAbnormal hemodynamics in schizophrenia during an auditory oddball task
Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.Peer-Reviewed Original ResearchConceptsAuditory oddball taskHealthy participantsOddball taskThree-stimulus auditory oddball taskDiffuse brain abnormalitiesHealthy control subjectsNovelty processingWidespread pathologic processCerebral areasControl subjectsBrain abnormalitiesMagnetic resonance imaging dataAbnormal hemodynamicsPathologic processesSchizophrenia patientsParietal cortexCognitive functionHeterogeneous disorderCerebellar circuitsSchizophreniaAbnormalitiesSignificant activationSubcortical systemsFunctional magnetic resonance imaging (fMRI) dataPatientsAn adaptive reflexive processing model of neurocognitive function: supporting evidence from a large scale (n = 100) fMRI study of an auditory oddball task
Kiehl KA, Stevens MC, Laurens KR, Pearlson G, Calhoun VD, Liddle PF. An adaptive reflexive processing model of neurocognitive function: supporting evidence from a large scale (n = 100) fMRI study of an auditory oddball task. NeuroImage 2005, 25: 899-915. PMID: 15808990, DOI: 10.1016/j.neuroimage.2004.12.035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsArousalAttentionBrainBrain MappingDominance, CerebralEvent-Related Potentials, P300FemaleHemodynamicsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve NetOxygenPitch DiscriminationReaction TimeReflexSex FactorsStatistics as TopicConceptsTask performanceNovel stimuliTask-relevant target stimuliProcessing of salientBrain regionsSuccessful task performanceAuditory oddball taskFunctional MRI studyNovelty processingReflexive processingSalient stimuliTarget stimuliOddball taskFMRI studyRandom effects statistical modelSubcortical systemsProcessing modelEffect of genderNeurocognitive functionInter-subject reliabilityEffects statistical modelStimuliSignificant activationFixed-effects analysisTarget detection