2021
Virtual Telesimulation for Medical Students During the COVID-19 Pandemic
Ray JM, Wong AH, Yang TJ, Buck S, Joseph M, Bonz JW, Auerbach MA, Couturier K, Tomassoni AJ, Schwartz ML, Evans LV. Virtual Telesimulation for Medical Students During the COVID-19 Pandemic. Academic Medicine 2021, 96: 1431-1435. PMID: 33883398, PMCID: PMC8475640, DOI: 10.1097/acm.0000000000004129.Peer-Reviewed Original ResearchConceptsMedical studentsVideoconferencing platformUndergraduate medical educationImmersive educational experienceClinical skill developmentSimulation-based learningMedical student curriculumLearning experienceEducational experienceStudent curriculumClerkship rotationEducational modalitiesContent areasMedical educationMedical schoolsSkill developmentFacilitator interactionsStudentsOnline webinarsPatient actorsStudent volunteersCOVID-19 pandemicSimilar programsChat functionSchools
2020
Echo-Focusing in Transcranial Focused Ultrasound Thalamotomy for Essential Tremor: A Feasibility Study.
Jones RM, Huang Y, Meng Y, Scantlebury N, Schwartz ML, Lipsman N, Hynynen K. Echo-Focusing in Transcranial Focused Ultrasound Thalamotomy for Essential Tremor: A Feasibility Study. Movement Disorders : Official Journal Of The Movement Disorder Society 2020, 35: 2327-2333. PMID: 32815611, DOI: 10.1002/mds.28226.Peer-Reviewed Original ResearchYale University School of Medicine.
Belitsky R, Schwartz ML, Larkin SE, Roth A. Yale University School of Medicine. Academic Medicine : Journal Of The Association Of American Medical Colleges 2020, 95: S83-S86. PMID: 33626652, DOI: 10.1097/ACM.0000000000003458.Peer-Reviewed Original ResearchThe Use of Mobile Devices to Enhance Engagement and Integration with Curricular Content.
Leydon GB, Schwartz ML. The Use of Mobile Devices to Enhance Engagement and Integration with Curricular Content. The Yale Journal Of Biology And Medicine 2020, 93: 453-460. PMID: 32874152, PMCID: PMC7448388.Peer-Reviewed Original ResearchSuspending Medical Student Clerkships Due to COVID-19
Goldenberg MN, Hersh DC, Wilkins KM, Schwartz ML. Suspending Medical Student Clerkships Due to COVID-19. Medical Science Educator 2020, 30: 1273-1276. PMID: 32837784, PMCID: PMC7266676, DOI: 10.1007/s40670-020-00994-1.Peer-Reviewed Original ResearchImpaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels
Quraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P, Kaczmarek LK. Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels. Scientific Reports 2020, 10: 3213. PMID: 32081855, PMCID: PMC7035262, DOI: 10.1038/s41598-020-60028-z.Peer-Reviewed Original ResearchConceptsMaximum electroshock-induced seizuresEpilepsy of infancyPentylenetetrazole-induced seizuresVideo-EEG monitoringElectroshock-induced seizuresForms of epilepsyWild-type miceSlack channelsImpaired motor skillsProcedural motor learningMotor skillsWild-type animalsSevere intellectual disabilityOpen-field behaviorCortical seizuresKCNT1 geneSpontaneous seizuresFocal seizuresSeizure susceptibilitySeizure activityType miceMouse modelAnimal modelsInterictal spikesSeizures
2019
Readiness for Medical School: a Radical Proposal
Angoff NR, Schwartz ML. Readiness for Medical School: a Radical Proposal. Medical Science Educator 2019, 30: 573-576. PMID: 34457704, PMCID: PMC8368260, DOI: 10.1007/s40670-019-00858-3.Peer-Reviewed Original ResearchPrinciples and Practices for Developing an Integrated Medical School Curricular Sequence About Sexual and Gender Minority Health
Encandela J, Zelin NS, Solotke M, Schwartz ML. Principles and Practices for Developing an Integrated Medical School Curricular Sequence About Sexual and Gender Minority Health. Teaching And Learning In Medicine 2019, 31: 319-334. PMID: 30661414, DOI: 10.1080/10401334.2018.1559167.Peer-Reviewed Original ResearchConceptsAmerican Medical CollegesCurricular componentsCurricular sequenceGender minority patientsCurriculum development practicesRevision of curriculaMedical education environmentMedical education communityGender minority contentLanguage of collaborationGender minority healthMedical CollegeNew curriculumStudent developmentCurriculum evaluationEducation communityEducation environmentCore principlesCurricular interventionsProfessional competenciesFaculty ownershipFaculty rolesMedical studentsCurriculumMinority content
2018
When patients hurt us
Cyrus KD, Angoff NR, Illuzzi JL, Schwartz ML, Wilkins KM. When patients hurt us. Medical Teacher 2018, 40: 1308-1309. PMID: 29375008, DOI: 10.1080/0142159x.2018.1428291.Peer-Reviewed Original Research
2017
Twelve tips for incorporating and teaching sexual and gender minority health in medical school curricula
Solotke M, Sitkin NA, Schwartz ML, Encandela JA. Twelve tips for incorporating and teaching sexual and gender minority health in medical school curricula. Medical Teacher 2017, 41: 141-146. PMID: 29179617, DOI: 10.1080/0142159x.2017.1407867.Peer-Reviewed Original ResearchConceptsIndividual educatorsMedical curriculumHealth contentUndergraduate medical educationMedical school curriculumUndergraduate medical curriculumGender minority healthPedagogical methodsSchool curriculumCurricular contentCurricular materialsMedical educationLack of supportCurriculumHealth of lesbianEducatorsGender minoritiesTeachingMinority HealthEducationLogistical barriersChallengesTransgender patientsContentLesbiansUsing learning analytics to evaluate a video-based lecture series
Lau KHV, Farooque P, Leydon G, Schwartz ML, Sadler RM, Moeller JJ. Using learning analytics to evaluate a video-based lecture series. Medical Teacher 2017, 40: 91-98. PMID: 29113565, DOI: 10.1080/0142159x.2017.1395001.Peer-Reviewed Original ResearchConceptsMassive Open Online CoursesVideo-based lecturesAccessible massive open online coursesAudience retentionVideo-sharing platformsOpen Online CoursesUsage dataView countVideoAnalytic dataOnline coursesLearner feedbackCore conceptsAnalyticsYouTubeFeedbackPlatformComprehensive evaluationLearnersElectroencephalography interpretationFlipped classroomModelDetailed evaluationWhy Not Wait? Eight Institutions Share Their Experiences Moving United States Medical Licensing Examination Step 1 After Core Clinical Clerkships.
Daniel M, Fleming A, Grochowski CO, Harnik V, Klimstra S, Morrison G, Pock A, Schwartz ML, Santen S. Why Not Wait? Eight Institutions Share Their Experiences Moving United States Medical Licensing Examination Step 1 After Core Clinical Clerkships. Academic Medicine : Journal Of The Association Of American Medical Colleges 2017, 92: 1515-1524. PMID: 28422816, DOI: 10.1097/ACM.0000000000001714.Peer-Reviewed Original ResearchLoss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior
Xenos D, Kamceva M, Tomasi S, Cardin JA, Schwartz ML, Vaccarino FM. Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior. Cerebral Cortex 2017, 28: 3399-3413. PMID: 28968898, PMCID: PMC6132287, DOI: 10.1093/cercor/bhx173.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCerebral CortexElectrophysiological PhenomenaEvoked PotentialsInterneuronsLearning DisabilitiesMembrane GlycoproteinsMemory DisordersMice, Inbred C57BLMice, KnockoutMovement DisordersNeocortexNeuronsParvalbuminsProtein-Tyrosine KinasesPyramidal CellsSurvival AnalysisConceptsBrain-derived neurotrophic factorCKO miceBasket cellsParvalbumin cellsExcitatory neuronsParvalbumin-expressing (PV-expressing) basket cellsPutative excitatory neuronsParvalbumin-Expressing InterneuronsPrincipal excitatory neuronsInhibitory synaptic connectionsCell-intrinsic roleCortical interneuron developmentConditional knockout miceTrkB receptorsMotor deficitsTrkB SignalingPyramidal neuronsGABAergic systemNeurotrophic factorLocal field potentialsProfound hyperactivityCortical volumeNeuronal activityKnockout miceSensory cortexMMP-2: A modulator of neuronal precursor activity and cognitive and motor behaviors
Li Q, Michaud M, Shankar R, Canosa S, Schwartz M, Madri JA. MMP-2: A modulator of neuronal precursor activity and cognitive and motor behaviors. Behavioural Brain Research 2017, 333: 74-82. PMID: 28666838, DOI: 10.1016/j.bbr.2017.06.041.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell MovementCell ProliferationCells, CulturedCognitionExploratory BehaviorGene Expression RegulationMatrix Metalloproteinase 2MiceMice, Inbred C57BLMice, KnockoutMotor ActivityNerve Tissue ProteinsNeural Stem CellsNeurogenesisOncogene Protein v-aktProliferating Cell Nuclear AntigenReceptors, CXCR4Spatial LearningConceptsNeural precursor cellsBroad substrate specificityNeurosphere formationAdherent neurospheresSecondary neurosphere formationNPC activitySubstrate specificityNPC numberCell surface moleculesZinc-containing enzymesAkt activationAbsence of MMP2Cell typesExtracellular matrixActivity assaysPrecursor cellsImportant roleNPC migrationMatrix metalloproteinase2Surface moleculesExpressionKO miceBioactive moleculesNestin expressionMMP2A Video-Based Introductory EEG Curriculum for Neurology Residents and Other EEG Learners
Moeller JJ, Farooque P, Leydon G, Dominguez M, Schwartz ML, Sadler RM. A Video-Based Introductory EEG Curriculum for Neurology Residents and Other EEG Learners. MedEdPORTAL 2017, 13: 10570. PMID: 30800772, PMCID: PMC6342517, DOI: 10.15766/mep_2374-8265.10570.Peer-Reviewed Original ResearchExpert teachersTeaching videosSupport learningCurriculumDifficult conceptsFormal educationNeurology residency programsAccreditation CouncilVideo-based approachResidency programsReading sessionsLearnersNeurology residentsFoundational principlesLecturesTime limitationsRespondentsVideoTeachersTeachingHalf of respondentsEducationLearningSkillsConceptThe role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups
Li Q, Michaud M, Park C, Huang Y, Couture R, Girodano F, Schwartz ML, Madri JA. The role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups. Laboratory Investigation 2017, 97: 356-369. PMID: 28092362, DOI: 10.1038/labinvest.2016.154.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisBlotting, WesternCell HypoxiaCell ProliferationCells, CulturedDentate GyrusEndothelial CellsFemaleHypoxiaHypoxia-Inducible Factor 1, alpha SubunitLateral VentriclesMaleMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, FluorescenceMotor ActivityNeural Stem CellsConceptsHIF-1 αBrain microvascular endothelial cellsNeuronal precursor cellsSubventricular zoneMicrovascular endothelial cellsOpen-field activityEndothelial cellsSublethal hypoxiaHIF-1 α expressionOpen-field activity testChronic sublethal hypoxiaEndothelial HIF-1Hypoxic conditionsC57BL/6 mouse pupsGender-specific differencesPremature birthC57BL/6 WTDentate gyrusHippocampal tissueDeficient miceΑ expressionMouse pupsMotor handicapParacrine effectsDentate gyrus tissue
2016
Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors
Salmaso N, Stevens HE, McNeill J, ElSayed M, Ren Q, Maragnoli ME, Schwartz ML, Tomasi S, Sapolsky RM, Duman R, Vaccarino FM. Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors. Biological Psychiatry 2016, 80: 479-489. PMID: 27133954, PMCID: PMC8009045, DOI: 10.1016/j.biopsych.2016.02.026.Peer-Reviewed Original ResearchConceptsFibroblast growth factor-2Hippocampal glucocorticoid receptor expressionGlucocorticoid receptor expressionAdrenal axis activityKO miceAxis activityAnxiety behaviorReceptor expressionHypothalamic-pituitary axis activityReceptor KO miceFGF2 administrationWild-type miceGrowth factor 2Receptor subtypesTherapeutic effectNeuroendocrine studiesAdult miceGlucocorticoid receptorGR promoter regionsFGF2 levelsMeasures of anxietyMiceMotor behaviorFGF2 geneFactor 2Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus
Varela L, Schwartz ML, Horvath TL. Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus. Neurobiology Of Disease 2016, 90: 68-74. PMID: 26777666, DOI: 10.1016/j.nbd.2016.01.004.Peer-Reviewed Original ResearchConceptsHippocampal neuronsMitochondria-endoplasmic reticulum interactionUCP2-KO miceEarly postnatal exposureLoss of synapsesOxygen tensionHigher brain regionsAdaptive mitochondrial responsesProtein 2 expressionHypothalamic circuitsPostnatal exposureKO miceSynaptic remodelingSystemic metabolismSynaptic inputsBrain cellsMetabolic controlNeuronal mitochondriaBrain regionsAdaptive responseNeuronsHippocampusMitochondrial dynamicsMetabolic challengesCortexArticle Commentary: Online Learning Tools as Supplements for Basic and Clinical Science Education
Ellman MS, Schwartz ML. Article Commentary: Online Learning Tools as Supplements for Basic and Clinical Science Education. Journal Of Medical Education And Curricular Development 2016, 3: jmecd.s18933. PMID: 29349323, PMCID: PMC5736292, DOI: 10.4137/jmecd.s18933.Peer-Reviewed Original ResearchOnline learning toolsOnline learningLearning toolsClinical science educationUndergraduate medical educatorsIndividual learning activitiesClinical communication skillsClinical sciences curriculumFlipped classroomLearning activitiesScience educationScience curriculumFaculty developmentMedical educatorsMedical educationCommunication skillsFoundational knowledgeLearningClassroomCurriculumEducatorsEducationContemporary trendsPedagogySkills
2015
Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development
Salmaso N, Dominguez M, Kravitz J, Komitova M, Vaccarino FM, Schwartz ML. Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development. Neuroscience Letters 2015, 604: 12-17. PMID: 26222256, PMCID: PMC4568169, DOI: 10.1016/j.neulet.2015.07.033.Peer-Reviewed Original ResearchConceptsBrain weightEffects of hypoxiaDam exposureCortical volumeBody weightHypoxic conditionsBrain developmentChronic postnatal hypoxiaLow birth weightPup body weightSame hypoxic conditionsChronic hypoxia exposureEarly postnatal pupsBody weight conditionsHypoxic mothersNeurological sequelaePostnatal hypoxiaPremature infantsHypoxic pupsBirth weightChronic hypoxiaHypoxic chamberHypoxic exposureLive birthsMouse model