2017
Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila
Chen D, Sitaraman D, Chen N, Jin X, Han C, Chen J, Sun M, Baker BS, Nitabach MN, Pan Y. Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila. Nature Communications 2017, 8: 154. PMID: 28754889, PMCID: PMC5533705, DOI: 10.1038/s41467-017-00087-5.Peer-Reviewed Original Research
2015
Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body
Sitaraman D, Aso Y, Rubin GM, Nitabach MN. Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body. Frontiers In Neural Circuits 2015, 9: 73. PMID: 26617493, PMCID: PMC4637407, DOI: 10.3389/fncir.2015.00073.Peer-Reviewed Original ResearchPropagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body
Sitaraman D, Aso Y, Jin X, Chen N, Felix M, Rubin GM, Nitabach MN. Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body. Current Biology 2015, 25: 2915-2927. PMID: 26455303, PMCID: PMC4654684, DOI: 10.1016/j.cub.2015.09.017.Peer-Reviewed Original ResearchConceptsSynaptic microcircuitsDrosophila mushroom bodyKenyon cellsMushroom bodiesMB neuronsControl of sleepHomeostatic rebound sleepHomeostatic sleep regulationIncreases sleepRebound sleepSleep regulationMBONsSleep deprivationNeuron classesSleepSleep informationMemory centerSpecific functional connectionsFunctional connectionsNeuronsPhysiological approachDifferent populationsMicrocircuits
2014
Rhythmic control of activity and sleep by class B1 GPCRs
Kunst M, Tso MC, Ghosh DD, Herzog ED, Nitabach MN. Rhythmic control of activity and sleep by class B1 GPCRs. Critical Reviews In Biochemistry And Molecular Biology 2014, 50: 18-30. PMID: 25410535, PMCID: PMC4648372, DOI: 10.3109/10409238.2014.985815.Peer-Reviewed Original ResearchConceptsGenetic model organismClass B1 GPCRsModel organismsC. elegansMetazoan cladesMolecular roleCircadian timekeepingB1 familyMolecular mechanismsG proteinsRhythmic controlDaily rhythmsCircadian rhythmRemarkable parallelsMultiple cellsDrosophilaCladeElegansPDFRGPCRsIntercellularReceptorsOrganismsVPAC2 receptorsTimekeepingCalcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila
Kunst M, Hughes ME, Raccuglia D, Felix M, Li M, Barnett G, Duah J, Nitabach MN. Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila. Current Biology 2014, 24: 2652-2664. PMID: 25455031, PMCID: PMC4255360, DOI: 10.1016/j.cub.2014.09.077.Peer-Reviewed Original ResearchConceptsPigment-dispersing factorNeuropeptide calcitonin gene-related peptideCalcitonin gene-related peptideGene-related peptidePDF receptorClock neuronsCircadian clock neuronsDistinct neuronal pathwaysNeuropeptide pigment-dispersing factorDorsal clock neuronsAmount of sleepHomeostatic sleep driveNeurons actsCalcitonin geneNeuronal pathwaysTiming of sleepSleepMental healthSleep driveReceptorsNovel roleCircadian rhythmDH31NeuronsLocomotor rhythmMushroom body output neurons encode valence and guide memory-based action selection in Drosophila
Aso Y, Sitaraman D, Ichinose T, Kaun KR, Vogt K, Belliart-Guérin G, Plaçais PY, Robie AA, Yamagata N, Schnaitmann C, Rowell WJ, Johnston RM, Ngo TT, Chen N, Korff W, Nitabach MN, Heberlein U, Preat T, Branson KM, Tanimoto H, Rubin GM. Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila. ELife 2014, 3: e04580. PMID: 25535794, PMCID: PMC4273436, DOI: 10.7554/elife.04580.Peer-Reviewed Original Research