Above the legal limit: Alcohol brings ER and mitochondria too close together
Guerra M, Nathanson M. Above the legal limit: Alcohol brings ER and mitochondria too close together. Cell Calcium 2023, 113: 102763. PMID: 37235972, PMCID: PMC10726477, DOI: 10.1016/j.ceca.2023.102763.Commentaries, Editorials and LettersMeSH KeywordsCalcium SignalingEndoplasmic ReticulumEndoplasmic Reticulum StressMitochondriaMitochondrial MembranesMitochondrial DNA and the STING pathway are required for hepatic stellate cell activation
Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelBioenergetic capacityMitochondrial DNATranscriptional upregulationCyclic GMP-AMP synthaseGMP-AMP synthaseTranscriptional regulationBioenergetic organellesFunctional mitochondriaMitochondrial membraneExternal mitochondrial membraneAnabolic pathwaysMitochondrial massAnion channelInterferon genesHSC transdifferentiationSubsequent activationCGAS-STINGTransdifferentiationIRF3 pathwayPathwaySTING pathwayGenesMitochondriaQuiescent HSCs