2001
Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver
Hirata K, Nathanson M. Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Gastroenterology 2001, 121: 396-406. PMID: 11487549, DOI: 10.1053/gast.2001.26280.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetylcholineAngiogenesis InhibitorsAnimalsAnti-Inflammatory Agents, Non-SteroidalBicarbonatesBileBile DuctsBiological TransportCalciumCyclic AMPCyclosporineDose-Response Relationship, DrugEnzyme InhibitorsEpithelial CellsGlucagonHepatic ArteryHepatic VeinsIn Vitro TechniquesLiverMaleNitrobenzoatesOrtho-AminobenzoatesRatsRats, Sprague-DawleySecretinVasoconstrictor AgentsVasodilator AgentsVasopressinsConceptsBiliary bicarbonate excretionEffect of secretinBicarbonate excretionHepatic arteryBiliary bicarbonateNormal rat liverDiphenylamine-2-carboxylic acidBile ductPortal veinRat liverEffects of acetylcholineBile duct epitheliumDose-dependent fashionFormation of bileBile flowBlood supplyBicarbonate exchangeDuct epitheliumAcetylcholineArteryAbstractTextExcretionCyclosporin A.LiverCholangiocytes
1999
Communication via gap junctions modulates bile secretion in the isolated perfused rat liver
Nathanson M, Rios–Velez L, Burgstahler A, Mennone A. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology 1999, 116: 1176-1183. PMID: 10220510, DOI: 10.1016/s0016-5085(99)70021-1.Peer-Reviewed Original Research
1998
Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells
Schmid S, Modlin I, Tang L, Stoch A, Rhee S, Nathanson M, Scheele G, Gorelick F. Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells. American Journal Of Physiology 1998, 274: g734-g741. PMID: 9575856, DOI: 10.1152/ajpgi.1998.274.4.g734.Peer-Reviewed Original ResearchConceptsPancreatic acinar cellsAmylase secretionRat pancreatic acinar cellsMuscarinic receptorsAcinar cellsDifferent muscarinic receptor antagonistsM2 antagonist methoctramineMaximal amylase secretionMuscarinic receptor antagonistIsolated rat pancreatic aciniRat pancreatic aciniAntagonist methoctramineM3 subtypeM1 antagonistMuscarinic subtypesReceptor antagonistZymogen processingAntagonist sensitivityPancreatic aciniSecretionAntagonistSubtypesPotent inhibitorReceptorsDistinct patterns
1994
Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver
Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CApical exocytosisRegulation of exocytosisProtein kinase C inhibitor HHorseradish peroxidase concentrationCytosolic Ca2ExocytosisCell typesInhibitor HProtein kinase C activator phorbol dibutyrateHorseradish peroxidase excretionPhorbol dibutyrateCa2Rat liverRelative importanceNet excretionPeroxidase concentrationsHepatocytes
1993
Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes
Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.Peer-Reviewed Original ResearchConceptsEffect of TUDCATauroursodeoxycholic acidAdministration of TUDCAIP3-independent mechanismCytosolic free calciumIP3-sensitive Ca2Trihydroxy bile acidsCholestatic disordersHepatocyte secretionTreatment periodExtracellular Ca2Bile acidsTaurolithocholic acidMumol/Rat hepatocytesFree calciumBasal levelsTransient increaseCytosolic Ca2Levels of inositolFree mediumPhysiological concentrationsIsolated rat hepatocytesHepatocytesFourfold increase
1992
Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver
Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.Peer-Reviewed Original ResearchMeSH KeywordsAequorinAnimalsBileCalcimycinCalciumCell SeparationCytosolHydroquinonesIn Vitro TechniquesLiverMalePressureRatsRats, Inbred StrainsVasopressinsConceptsBile flowPerfusion pressureBile secretionCytosolic Ca2Rat liverProtein kinase CIonophore-induced increaseBromo-A23187Hepatic vasoconstrictionVasodilator papaverineProtein kinase C inhibitor HExtracellular Ca2Kinase CSecretionLiverVasopressinAgonist vasopressinBenzohydroquinoneEffect of Ca2HepatocytesActivate protein kinase CInhibitor HTwo-thirdsIsolated hepatocytesSensitive photoprotein aequorin