2001
Stimulation of ATP secretion in the liver by therapeutic bile acids
NATHANSON M, BURGSTAHLER A, MASYUK A, LaRUSSO N. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochemical Journal 2001, 358: 1-5. DOI: 10.1042/bj3580001.Peer-Reviewed Original ResearchBile duct epitheliumUrsodeoxycholic acidBile acidsSecretory disordersATP receptorsPerfusion of ATPBile duct segmentsEndogenous ATPTherapeutic bile acidsSecretion of ATPNumber of disordersMechanism of actionBile flowPharmacological activationPharmacological meansTherapeutic benefitElectrolyte secretionDelivery of ATPATP secretionCystic fibrosisOnly agentATP releaseBileCytosolic Ca2Liver
1993
Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes
Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.Peer-Reviewed Original ResearchConceptsEffect of TUDCATauroursodeoxycholic acidAdministration of TUDCAIP3-independent mechanismCytosolic free calciumIP3-sensitive Ca2Trihydroxy bile acidsCholestatic disordersHepatocyte secretionTreatment periodExtracellular Ca2Bile acidsTaurolithocholic acidMumol/Rat hepatocytesFree calciumBasal levelsTransient increaseCytosolic Ca2Levels of inositolFree mediumPhysiological concentrationsIsolated rat hepatocytesHepatocytesFourfold increase