2024
Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis
Fallahtafti P, Soleimani H, Ebrahimi P, Ghaseminejad‐Raeini A, Karimi E, Shirinezhad A, Sabri M, Mehrani M, Taheri H, Siegel R, Shah N, Nanna M, Hakim D, Hosseini K. Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis. Clinical Cardiology 2024, 47: e24324. PMID: 39054901, PMCID: PMC11272956, DOI: 10.1002/clc.24324.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCoronary artery diseasePercutaneous coronary interventionIn-hospital mortalityNetwork meta-analysisMyocardial infarctionAortic stenosisAssociated with worse 30-day outcomeMeta-analysisIncreased risk of 1-year mortalityAssociated with higher 1-year mortalityRisk of 1-year mortalitySevere aortic stenosisFrequentist network meta-analysisRates of myocardial infarctionPercutaneous coronary intervention timeTime of revascularizationAortic valve implantationSevere ASNo significant differencePacemaker implantationPost-TAVIValve implantationPatient characteristicsArtery diseaseChronological vs Biological Age in Interventional Cardiology A Comprehensive Approach to Care for Older Adults: JACC Family Series
Damluji A, Nanna M, Rymer J, Kochar A, Lowenstern A, Baron S, Narins C, Alkhouli M. Chronological vs Biological Age in Interventional Cardiology A Comprehensive Approach to Care for Older Adults: JACC Family Series. JACC Cardiovascular Interventions 2024, 17: 961-978. PMID: 38597844, PMCID: PMC11097960, DOI: 10.1016/j.jcin.2024.01.284.Peer-Reviewed Original ResearchConceptsCardiovascular careImprove health outcomesOlder adult populationPatient-centered outcomesBiological ageAge-associated riskAging global populationAge-related riskFamily seriesComplex careHealth outcomesJACC State-of-the-Art ReviewOlder AdultsChronic illnessInfluence eligibilityProcedural adverse eventsStructural heart diseaseClinical focusCareOlder individualsInvasive careAdult populationInterventionCardiovascular diseaseOlder patientsRisk Prediction for Atherosclerotic Cardiovascular Disease With and Without Race Stratification
Ghosh A, Venkatraman S, Nanna M, Safford M, Colantonio L, Brown T, Pinheiro L, Peterson E, Navar A, Sterling M, Soroka O, Nahid M, Banerjee S, Goyal P. Risk Prediction for Atherosclerotic Cardiovascular Disease With and Without Race Stratification. JAMA Cardiology 2024, 9: 55-62. PMID: 38055247, PMCID: PMC10701663, DOI: 10.1001/jamacardio.2023.4520.Peer-Reviewed Original ResearchConceptsLipoprotein cholesterol levelsAtherosclerotic cardiovascular diseaseCohort studyREGARDS cohortCholesterol levelsCardiovascular diseaseLow-density lipoprotein cholesterol levelsCoronary heart disease deathDensity lipoprotein cholesterol levelsRace-sex stratumHeart disease deathProspective cohort studyCohort risk equationsRisk predictionRace stratificationIncident ASCVDNonfatal strokeDisease deathsC-statisticMyocardial infarctionHigh riskRisk equationsSocial determinantsPercentage declineIncremental value
2023
Obesity and Undernutrition in Acute Myocardial Infarction
Mangalesh S, Nanna M. Obesity and Undernutrition in Acute Myocardial Infarction. The American Journal Of Cardiology 2023, 203: 529-530. PMID: 37563054, DOI: 10.1016/j.amjcard.2023.07.111.Peer-Reviewed Original ResearchDelirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes
Park D, Jamil Y, Hu J, Lowenstern A, Frampton J, Abdullah A, Damluji A, Ahmad Y, Soufer R, Nanna M. Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes. Cardiovascular Revascularization Medicine 2023, 57: 60-67. PMID: 37414611, PMCID: PMC10730763, DOI: 10.1016/j.carrev.2023.06.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityHigher oddsOlder adultsHospital deliriumCoronary interventionAdverse health-related outcomesInpatient percutaneous coronary interventionNon-home dischargePeri-procedural settingAcute kidney injuryImpact of deliriumPost-procedural complicationsNational Inpatient SampleHealth-related outcomesDelirium preventionHospital complicationsMore comorbiditiesGastrointestinal hemorrhageKidney injuryAdverse eventsSecondary outcomesBlood transfusionPrimary outcomeIntracranial hemorrhageClinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial
Nanna M, Yow E, Vemulapalli S, Mark D, Kelsey M, Patel M, Al-Khalidi H, Rogers C, Udelson J, Douglas P. Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial. American Heart Journal 2023, 261: 124-126. PMID: 36828202, PMCID: PMC10903188, DOI: 10.1016/j.ahj.2023.02.010.Peer-Reviewed Original ResearchThe Heterogeneity of Old Age Healthy Aging in Older Adults Undergoing TAVR ∗
Damluji A, Rymer J, Nanna M. The Heterogeneity of Old Age Healthy Aging in Older Adults Undergoing TAVR ∗. JACC Cardiovascular Interventions 2023, 16: 189-192. PMID: 36697155, PMCID: PMC9945654, DOI: 10.1016/j.jcin.2022.12.008.Peer-Reviewed Original Research
2022
Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease
Park DY, An S, Hanna JM, Wang SY, Cruz-Solbes AS, Kochar A, Lowenstern AM, Forrest JK, Ahmad Y, Cleman M, Al Damluji A, Nanna MG. Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease. PLOS ONE 2022, 17: e0276394. PMID: 36264931, PMCID: PMC9584363, DOI: 10.1371/journal.pone.0276394.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseTranscatheter aortic valve replacementLength of stayAortic valve replacementIndex hospitalizationHospital mortalityReadmission ratesValve replacementRenal diseaseLonger LOSNational Readmission DatabaseRisk of readmissionChronic pulmonary diseaseMultivariable logistic regressionCardiovascular causesCardiovascular readmissionCause readmissionHospital readmissionPulmonary diseaseHospital chargesPoor outcomeRisk factorsHospital costsReadmissionHigher oddsReadmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia
Park DY, Sana MK, Shoura S, Hammo H, Hu JR, Forrest JK, Lowenstern A, Cleman M, Ahmad Y, Nanna MG. Readmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia. Cardiovascular Revascularization Medicine 2022, 46: 70-77. PMID: 35973922, PMCID: PMC10940024, DOI: 10.1016/j.carrev.2022.08.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementAortic stenosisValve replacementSecondary diagnosisHospital adverse outcomesAcute kidney injuryIn-Hospital OutcomesNational Readmission DatabasePresence of dementiaPrevalence of dementiaProportional hazards modelDecade of ageHigher hazardIndex hospitalizationInpatient outcomesKidney injuryDefinitive treatmentPacemaker placementReadmission riskAdverse outcomesReadmissionHigher oddsDecision-making discussionsHigh riskFrailty and outcomes following revascularization of lower-extremity peripheral artery disease: Insights from the Vascular Quality Initiative (VQI)
Al-Damluji MS, Smolderen KG, Meng C, Dai F, Nanna MG, Sumpio B, Henke P, Mena-Hurtado C. Frailty and outcomes following revascularization of lower-extremity peripheral artery disease: Insights from the Vascular Quality Initiative (VQI). Vascular Medicine 2022, 27: 251-257. PMID: 35485400, DOI: 10.1177/1358863x221083701.Peer-Reviewed Original ResearchConceptsRisk Analysis IndexVascular Quality InitiativeLower extremity revascularizationFrailty screening toolsMFI-5Lower extremity peripheral artery diseaseScreening toolFrailty detectionAddition of frailtyPAD risk factorsPeripheral artery diseasePAD populationRevascularization typeVascular cohortMajor amputationPerioperative outcomesArtery diseaseFrailty indexFrailty toolsAdjusted analysisUnplanned amputationRisk factorsHigher oddsPredictive valuePatientsAre risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial
Kolossváry M, Mayrhofer T, Ferencik M, Karády J, Pagidipati NJ, Shah SH, Nanna MG, Foldyna B, Douglas PS, Hoffmann U, Lu MT. Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial. Journal Of Cardiovascular Computed Tomography 2022, 16: 397-403. PMID: 35393245, PMCID: PMC9452442, DOI: 10.1016/j.jcct.2022.03.006.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary CT angiographyCalcium scoreRisk factorsLuminal narrowingPTP scoreArtery diseasePatient characteristicsPROMISE trialStable chest pain patientsObstructive coronary artery diseasePretest probability assessmentChest pain patientsSimilar risk profilesCT angiographyImaging markerRisk profileDiagnostic accuracyCAD predictionSex groupsProbability calculatorScoresSubanalysesDiseaseGroup individuals
2021
Bridging Antiplatelet Therapy After Percutaneous Coronary Intervention JACC Review Topic of the Week
Sullivan AE, Nanna MG, Wang TY, Bhatt DL, Angiolillo DJ, Mehran R, Banerjee S, Cantrell S, Jones WS, Rymer JA, Washam JB, Rao SV, Ohman EM. Bridging Antiplatelet Therapy After Percutaneous Coronary Intervention JACC Review Topic of the Week. Journal Of The American College Of Cardiology 2021, 78: 1550-1563. PMID: 34620413, DOI: 10.1016/j.jacc.2021.08.013.Peer-Reviewed Original ResearchConceptsDual antiplatelet therapyAntiplatelet therapyBridging therapySmall-molecule glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsIntravenous antiplatelet agentsOptimal antiplatelet strategyPerioperative risk factorsCoronary stent implantationMultidisciplinary risk assessmentIntravenous P2YEarly surgeryHemorrhagic complicationsAntiplatelet strategiesClinical characteristicsAntiplatelet agentsPerioperative careRisk stratificationComplex patientsStent implantationRisk factorsCurrent guidelinesOptimal managementTherapyThe Cumulative Impact of Chronic Stressors on Risks of Myocardial Infarction in US Older Adults
Dupre ME, Farmer HR, Xu H, Navar AM, Nanna MG, George LK, Peterson ED. The Cumulative Impact of Chronic Stressors on Risks of Myocardial Infarction in US Older Adults. Psychosomatic Medicine 2021, 83: 987-994. PMID: 34297011, PMCID: PMC8578196, DOI: 10.1097/psy.0000000000000976.Peer-Reviewed Original ResearchMeSH KeywordsAgedCohort StudiesHumansIncidenceMyocardial InfarctionProportional Hazards ModelsProspective StudiesRisk FactorsConceptsUS older adultsPrior myocardial infarctionMyocardial infarctionRisk factorsChronic stressorsOlder adultsMore chronic stressorsHistory of MISignificant independent risk factorsIncidence of MIRisk of MIClinical risk factorsIndependent risk factorAdults 45 yearsPrevious myocardial infarctionProspective cohort dataChronic life stressorsProportional hazards modelRace/ethnicityCardiovascular eventsMedian ageMultivariable modelHazards modelCumulative exposureCohort dataThe incremental value of angiographic features for predicting recurrent cardiovascular events: Insights from the Duke Databank for Cardiovascular Disease
Nanna MG, Peterson ED, Chiswell K, Overton RA, Nelson AJ, Kong DF, Navar AM. The incremental value of angiographic features for predicting recurrent cardiovascular events: Insights from the Duke Databank for Cardiovascular Disease. Atherosclerosis 2021, 321: 1-7. PMID: 33582446, PMCID: PMC8221430, DOI: 10.1016/j.atherosclerosis.2021.02.004.Peer-Reviewed Original ResearchConceptsSecondary risk predictionAngiographic featuresCardiovascular diseaseCardiovascular eventsClinical characteristicsDuke DatabankMultivariable modelIncremental valueRisk predictionAtherosclerotic cardiovascular disease eventsSignificant coronary artery diseaseBaseline clinical factorsDuke CAD indexRecurrent cardiovascular eventsCardiovascular disease eventsSame health systemCoronary artery diseasePrimary care physiciansCardiac catheterization patientsCoronary angiographic featuresRecurrent eventsRisk prediction modelAngiographic variablesInitial revascularizationAngiographic predictors180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study
Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Ouellet G, Sybrant D, Gill TM, Chaudhry SI. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study. Open Heart 2021, 8: e001442. PMID: 33452007, PMCID: PMC7813425, DOI: 10.1136/openhrt-2020-001442.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionReadmission risk modelSelf-reported health statusMyocardial infarctionFunctional mobilityOlder adultsHealth statusDays of AMIFirst diastolic blood pressureChronic obstructive pulmonary diseaseIschemic ECG changesProspective cohort studyDiastolic blood pressureObstructive pulmonary diseaseLength of stayInitial heart rateFinal risk modelSILVER-AMI StudyRisk modelInitial hemoglobinCohort studyReadmission ratesBlood pressureEjection fractionHeart failure
2020
Can the Absence of Hypertension Refine the Risk Assessment of Older Adults for Future Cardiovascular Events?
Nanna MG, Navar AM, Wojdyla D, Nelson AJ, Sullivan AE, Peterson ED. Can the Absence of Hypertension Refine the Risk Assessment of Older Adults for Future Cardiovascular Events? The American Journal Of Cardiology 2020, 142: 83-90. PMID: 33279483, PMCID: PMC8221431, DOI: 10.1016/j.amjcard.2020.11.027.Peer-Reviewed Original ResearchConceptsSystolic blood pressureAtherosclerotic cardiovascular diseaseAbsence of hypertensionBlood pressureCardiovascular diseaseCardiovascular eventsEvent ratesOlder adultsLower CVD event ratesLower systolic blood pressureASCVD event ratesCVD event ratesDiastolic blood pressureFuture cardiovascular eventsASCVD riskRisk stratificationPooled cohortMultivariable modelingHypertensionRisk scoreLower riskRisk estimatesNational InstituteObserved event ratesAdults
2019
Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study.
Dodson JA, Hajduk AM, Geda M, Krumholz HM, Murphy TE, Tsang S, Tinetti ME, Nanna MG, McNamara R, Gill TM, Chaudhry SI. Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study. Annals Of Internal Medicine 2019, 172: 12-21. PMID: 31816630, PMCID: PMC7695040, DOI: 10.7326/m19-0974.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPost-AMI mortalityFunctional impairmentOlder adultsCohort studyMean ageMyocardial infarctionPatient-reported health statusNet reclassification improvement indexProspective cohort studyParticipants' mean ageFinal risk modelMobility impairmentsGood discriminatory abilityRisk modelChart reviewHospital dischargePrognostic utilityBlood InstituteClinical variablesNational HeartHigh prevalenceHealth statusMortalityYounger counterpartsA systematic review of randomized trials comparing double versus triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention
Sullivan AE, Nanna MG, Rao SV, Cantrell S, Gibson CM, Verheugt FWA, Peterson ED, Lopes RD, Alexander JH, Granger CB, Yee MK, Kong DF. A systematic review of randomized trials comparing double versus triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention. Catheterization And Cardiovascular Interventions 2019, 96: e102-e109. PMID: 31713326, PMCID: PMC7211549, DOI: 10.1002/ccd.28535.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAnticoagulantsAtrial FibrillationCoronary ThrombosisDual Anti-Platelet TherapyFemaleFibrinolytic AgentsHemorrhageHumansMalePercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsRandomized Controlled Trials as TopicRisk FactorsTreatment OutcomeConceptsPercutaneous coronary interventionAcute coronary syndromeDouble therapyOral anticoagulationAtrial fibrillationTriple therapyAntithrombotic therapyCoronary syndromeCoronary interventionStent thrombosisMajor adverse cardiovascular eventsTriple antithrombotic therapyAdverse cardiovascular eventsDual antiplatelet therapyOptimal antithrombotic therapyGood safety profileRandom-effects modelIschemic outcomesAntiplatelet therapyCardiovascular eventsP2Y12 inhibitorsMedical managementRandomized trialsIntracranial hemorrhageSafety profileThe Accuracy of Cardiovascular Pooled Cohort Risk Estimates in U.S. Older Adults
Nanna MG, Peterson ED, Wojdyla D, Navar AM. The Accuracy of Cardiovascular Pooled Cohort Risk Estimates in U.S. Older Adults. Journal Of General Internal Medicine 2019, 35: 1701-1708. PMID: 31667745, PMCID: PMC7280419, DOI: 10.1007/s11606-019-05361-4.Peer-Reviewed Original ResearchConceptsAtherosclerotic cardiovascular diseaseOlder adultsACC/AHA guidelinesAge groupsLarge prospective cohort studyRisk estimatesYoung adultsASCVD risk estimationProspective cohort studyCardiovascular Health StudyHigh-risk groupU.S. older adultsDifferent age groupsCHD deathFramingham OriginalASCVD riskCardiovascular eventsAHA guidelinesCohort studyPrimary preventionCardiovascular diseaseRisk groupsTreatment decisionsFramingham OffspringHealth StudySex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction
Nanna MG, Hajduk AM, Krumholz HM, Murphy TE, Dreyer RP, Alexander KP, Geda M, Tsang S, Welty FK, Safdar B, Lakshminarayan DK, Chaudhry SI, Dodson JA. Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005691. PMID: 31607145, PMCID: PMC6913190, DOI: 10.1161/circoutcomes.119.005691.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDisability EvaluationFemaleHealth Status DisparitiesHealthcare DisparitiesHumansLife StyleMaleMyocardial RevascularizationNon-ST Elevated Myocardial InfarctionPatient AdmissionPrevalenceProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocial Determinants of HealthST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionSex-based differencesPercutaneous coronary interventionFunctional impairmentOlder adultsHospital complicationsCoronary interventionOlder patientsCoronary diseaseMyocardial infarctionAge-related functional impairmentsAge-associated functional impairmentsLower ratesPrior coronary diseaseObstructive coronary diseaseProspective observational studyNSTEMI subgroupSTEMI subgroupUnderwent revascularizationAcute myocardialChest painClinical presentationAMI subgroupRisk factorsHigh prevalence