2022
Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding
Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAgedAged, 80 and overAspirinCardiovascular DiseasesGastrointestinal HemorrhageHumansMiddle AgedPatient DischargePrimary PreventionConceptsMajor adverse cardiovascular eventsGastrointestinal bleedingPrimary preventionCardiovascular eventsRisk of MACEYale-New Haven HospitalPrimary cardiovascular preventionAdverse cardiovascular eventsKaplan-Meier curvesLong-term outcomesRisk-benefit ratioLog-rank testAspirin 81Hospitalised patientsPrimary endpointSecondary endpointsCardiovascular preventionSubsequent hospitalisationMedian ageDeprescriptionHigh riskAspirinHospitalisationPatientsPreventionPrimary prevention statin therapy in older adults
Nanna M, Abdullah A, Mortensen M, Navar A. Primary prevention statin therapy in older adults. Current Opinion In Cardiology 2022, 38: 11-20. PMID: 36598445, PMCID: PMC9830552, DOI: 10.1097/hco.0000000000001003.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedCardiovascular DiseasesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPrimary PreventionConceptsAge 75Older adult populationStatin treatmentRandomized trialsAdult populationPrimary prevention statin therapyOlder adultsAverage lifespan increasesRecent guideline recommendationsACC/AHAOngoing randomized trialsPrevention of morbidityPaucity of evidenceStatin therapyStatin useUSPSTF recommendationsOlder patientsGuideline recommendationsOngoing trialsTreatment recommendationsCardiovascular diseaseTreatment benefitTreatment decisionsGuidelines conflictTrials
2019
Sex Differences in the Use of Statins in Community Practice
Nanna MG, Wang TY, Xiang Q, Goldberg AC, Robinson JG, Roger VL, Virani SS, Wilson PWF, Louie MJ, Koren A, Li Z, Peterson ED, Navar AM. Sex Differences in the Use of Statins in Community Practice. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005562. PMID: 31416347, PMCID: PMC6903404, DOI: 10.1161/circoutcomes.118.005562.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCommunity Health ServicesDyslipidemiasFemaleGuideline AdherenceHealth Knowledge, Attitudes, PracticeHealthcare DisparitiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMedication AdherenceMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Primary PreventionRegistriesRisk AssessmentRisk FactorsSecondary PreventionSex FactorsTime FactorsTreatment OutcomeTreatment RefusalUnited StatesConceptsStatin therapyStatin treatmentStatin useCardiology/American Heart Association cholesterol guidelinesAmerican Heart Association cholesterol guidelinesGuideline-recommended statin intensityHeart Association cholesterol guidelinesSex differencesAggressive lipid managementGuideline-recommended intensityLipid Management (PALM) registrySecondary prevention indicationUse of statinsAtherosclerotic cardiovascular diseaseMultivariable logistic regressionCholesterol guidelinesStatin dosingStatin intensityLipid managementClinical characteristicsNationwide registryPrevention indicationMale patientsManagement RegistryFemale patientsPractice-level variation in statin use and low-density lipoprotein cholesterol control in the United States: Results from the Patient and Provider Assessment of Lipid Management (PALM) registry
Nanna MG, Navar AM, Wang TY, Li S, Virani SS, Li Z, Robinson JG, Roger VL, Wilson PWF, Goldberg AC, Koren A, Louie MJ, Peterson ED. Practice-level variation in statin use and low-density lipoprotein cholesterol control in the United States: Results from the Patient and Provider Assessment of Lipid Management (PALM) registry. American Heart Journal 2019, 214: 113-124. PMID: 31202098, PMCID: PMC6639125, DOI: 10.1016/j.ahj.2019.05.009.Peer-Reviewed Original ResearchConceptsLow-density lipoprotein cholesterol controlMedian odds ratioAtherosclerotic cardiovascular diseaseStatin useStatin intensityStatin therapyCholesterol controlProvider assessmentGuideline-recommended statin intensityGuideline-recommended intensityLipid Management (PALM) registrySecondary prevention patientsLDL-C levelsPractice-level variationEligible patientsStatin recommendationsStatin treatmentManagement RegistryGuideline recommendationsPatient's likelihoodUS patientsSimilar patientsTreatment indicationsUS clinicsOdds ratio
2018
Association of Patient Perceptions of Cardiovascular Risk and Beliefs on Statin Drugs With Racial Differences in Statin Use: Insights From the Patient and Provider Assessment of Lipid Management Registry
Nanna MG, Navar AM, Zakroysky P, Xiang Q, Goldberg AC, Robinson J, Roger VL, Virani SS, Wilson PWF, Elassal J, Lee LV, Wang TY, Peterson ED. Association of Patient Perceptions of Cardiovascular Risk and Beliefs on Statin Drugs With Racial Differences in Statin Use: Insights From the Patient and Provider Assessment of Lipid Management Registry. JAMA Cardiology 2018, 3: 739-748. PMID: 29898219, PMCID: PMC6656582, DOI: 10.1001/jamacardio.2018.1511.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtherosclerosisAttitude to HealthBlack or African AmericanCholesterol, LDLFemaleGuideline AdherenceHealthcare DisparitiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasMaleMiddle AgedPerceptionPrimary PreventionRegistriesRiskSecondary PreventionSocial ClassUnited StatesWhite PeopleConceptsAfrican American patientsAfrican American individualsStatin therapyStatin useWhite individualsAmerican patientsPatients' beliefsProvider assessmentCardiology/American Heart Association guidelinesMedian low-density lipoprotein (LDL) cholesterol levelLow-density lipoprotein cholesterol levelsGuideline-recommended statin therapyAtherosclerotic cardiovascular disease riskAmerican Heart Association guidelinesGuideline-recommended intensityLipid Management (PALM) registryHeart Association guidelinesLipoprotein cholesterol levelsCardiovascular disease riskAmerican individualsCommunity health care practicesClinician differencesHealth care practicesPALM registryCardiovascular riskStatin Use and Adverse Effects Among Adults >75 Years of Age: Insights From the Patient and Provider Assessment of Lipid Management (PALM) Registry
Nanna MG, Navar AM, Wang TY, Mi X, Virani SS, Louie MJ, Lee LV, Goldberg AC, Roger VL, Robinson J, Peterson ED. Statin Use and Adverse Effects Among Adults >75 Years of Age: Insights From the Patient and Provider Assessment of Lipid Management (PALM) Registry. Journal Of The American Heart Association 2018, 7: e008546. PMID: 29739801, PMCID: PMC6015311, DOI: 10.1161/jaha.118.008546.Peer-Reviewed Original ResearchConceptsLipid Management (PALM) registryHigh-dose statinsHigh-intensity statinsStatin useOlder patientsSecondary preventionManagement RegistryPrimary preventionProvider assessmentCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesMultivariable logistic regression modelRoutine community practiceHeart Association guidelinesCurrent statin usersCurrent statin useYears of ageLogistic regression modelsStatin usersYounger patientsPatient surveyAssociation guidelinesAmerican CollegeStatinsPatients