2022
Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis
Park DY, Wang P, An S, Grimshaw AA, Frampton J, Ohman EM, Rao SV, Nanna MG. Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis. American Heart Journal 2022, 251: 101-114. PMID: 35654162, PMCID: PMC10904033, DOI: 10.1016/j.ahj.2022.05.019.Peer-Reviewed Original ResearchConceptsMonths of DAPTHazard ratioIschemic eventsDuration of DAPTSelect patient characteristicsDual antiplatelet therapyAcute coronary syndromeCoronary artery lesionsPercutaneous coronary interventionConfidence intervalsAssociation of outcomesRandom-effects modelComprehensive literature searchMeta-regression analysisMajor bleedingAntiplatelet therapyCoronary syndromeArtery lesionsCoronary interventionControlled TrialsPatient characteristicsPrespecified outcomesGreater proportionSimilar efficacySystematic review
2020
In ACS, ticagrelor and prasugrel each reduce some ischemic events but increase major bleeding vs. clopidogrel.
Nanna MG, Granger CB. In ACS, ticagrelor and prasugrel each reduce some ischemic events but increase major bleeding vs. clopidogrel. Annals Of Internal Medicine 2020, 173: jc44. PMID: 33075264, DOI: 10.7326/acpj202010200-044.Peer-Reviewed Original Research
2017
Benefits and risks of P2Y12 inhibitor preloading in patients with acute coronary syndrome and stable angina
Bazemore TC, Nanna MG, Rao SV. Benefits and risks of P2Y12 inhibitor preloading in patients with acute coronary syndrome and stable angina. Journal Of Thrombosis And Thrombolysis 2017, 44: 303-315. PMID: 28730406, DOI: 10.1007/s11239-017-1529-6.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeP2Y12 inhibitorsStable anginaCoronary syndromeCardiac catheterizationCoronary artery bypass graft surgeryArtery bypass graft surgeryAdverse ischemic eventsP2Y12 inhibitor administrationP2Y12 inhibitor pretreatmentAdverse cardiovascular eventsBypass graft surgeryPercutaneous coronary interventionStandard of careCardiovascular eventsGraft surgeryCoronary interventionIschemic eventsInhibitor administrationOperative delayPatientsInhibitor pretreatmentAnginaCatheterizationAppropriate timing