2001
Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells
Seebach F, Welte T, Fu X, Block L, Kashgarian M. Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells. Experimental And Molecular Pathology 2001, 70: 265-273. PMID: 11418005, DOI: 10.1006/exmp.2001.2361.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IICells, CulturedDNA-Binding ProteinsFetusGlomerular MesangiumHumansKineticsMilk ProteinsPhosphorylationProtein TransportReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Receptors, AngiotensinSTAT1 Transcription FactorSTAT2 Transcription FactorSTAT5 Transcription FactorTrans-ActivatorsConceptsDNA-binding activityHuman mesangial cellsStat5 DNA-binding activityNuclear translocationSTAT-DNA bindingAngiotensin IISTAT5 tyrosine phosphorylationElectromobility shift assaysReceptor subtype-specific mannerMesangial cellsReceptor-specific signalingSTAT proteinsTyrosine phosphorylationShift assaysTranscription pathwayHuman fetal mesangial cellsSignal transducerSubtype-specific mannerCellular responsesSTAT pathwayAngiotensin receptor type 2Renal mesangial cellsAngiotensin II resultsVasoactive peptide angiotensin IIPossible regulator
1983
Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats.
Stein H, Feddergreen W, Kashgarian M, Sterzel R. Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats. Laboratory Investigation 1983, 49: 270-80. PMID: 6350702.Peer-Reviewed Original ResearchConceptsBlood pressureFiltration fractionMesangial localizationAngiotensin IIFunctional changesAcute angiotensin IIAminohippuric acid clearanceRenal functional changesSystolic blood pressureExcretion of albuminSingle intravenous doseGlomerular capillary permeabilityGroups of ratsInjection of ferritinPressor doseAcid clearanceIntravenous doseMesangial depositionMesangial accumulationFerritin concentrationInulin clearanceTreatment periodRenal tissueSerial measurementsFerritin deposition
1970
A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency
Kotchen T, Knight E, Kashgarian M, Mulrow P. A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency. Nephron 1970, 7: 317-330. PMID: 4316656, DOI: 10.1159/000179832.Peer-Reviewed Original ResearchConceptsRenin activitySevere chronic renal insufficiencyChronic dialysis programRenin substrate levelsChronic renal insufficiencyPlasma renin activityMean arterial pressureRenin-angiotensin systemNormal plasma levelsMalignant hypertensionRenal insufficiencyRenin levelsOnly patientsArterial pressureBlood pressureUremic patientsDialysis programPlasma levelsUremic plasmaAutopsy specimensJG cellsBowie stainPatientsReninDialysis